Article
Engineering, Environmental
Yaqiang Cao, Yuanyuan Chen, Ke Miao, Shuyi Zhang, Fuchang Deng, Mu Zhu, Chao Wang, Wen Gu, Yixuan Huang, Zijin Shao, Xiaoyan Dong, Yufeng Gong, Hui Peng, Hui Yang, Yi Wan, Xudong Jia, Song Tang
Summary: Mounting evidence shows the close association between ambient PM2.5 exposure and obesity development, with adipose tissue being an important target. This study employed a preadipocyte differentiation model to comprehensively explore the adipogenic potential of PM2.5. PM2.5 exposure significantly increased fatty acid uptake, lipid accumulation, and adipogenic differentiation in a concentration-dependent manner. Transcriptome and lipidome analyses revealed disruption of transcriptional and lipid profiling at 10 μg/mL PM2.5. Activation of the peroxisome proliferator-activated receptor (PPAR) pathway and metabolism of glycerophospholipids, glycerolipids, and sphingolipids were most affected during adipocyte differentiation. The study demonstrated that PM2.5 promoted adipogenesis by activating PPAR. through reporter gene assays. The findings provide insights into PM2.5-induced adipogenesis and potential biomolecular targets for preventing PM2.5-induced obesity and related metabolic diseases.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuankuan Li, Sung Ho Lee, Meiyu Piao, Hyung Sik Kim, Kwang Youl Lee
Summary: This study found that Metallothionein 3 (MT3) plays an important role in the differentiation of 3T3-L1 cells into adipocytes. Overexpression of MT3 inhibited adipocyte differentiation and reduced the levels of adipogenic transcription factors C/EBPa and PPAR?. Further analysis revealed that MT3 suppressed the transcriptional activity of PPAR?, and this effect was not mediated by a direct interaction between MT3 and PPAR?. Additionally, MT3 overexpression decreased reactive oxygen species (ROS) levels during early adipocyte differentiation, while treatment with antimycin A, which induces ROS generation, restored the ROS levels.
Article
Pharmacology & Pharmacy
Chaiwat Monmai, Jin-Suk Kim, Hyun Bo Sim, Doh-Won Yun, Sung-Dug Oh, Eui-Shik Rha, Jong-Jin Kim, So-Hyeon Baek
Summary: This study evaluated the effects of extracts from transgenic rice on inhibiting adipogenesis and anti-inflammatory activity. The results showed that the extracts significantly reduced lipid accumulation in cells and inhibited the expression of adipogenesis-related mRNA and inflammation-related factors. Therefore, transgenic rice may have potential as an obesity-reducing and/or -preventing agent.
Article
Biology
Catarina Teixeira, Andre P. Sousa, Ines Santos, Ana Catarina Rocha, Ines Alencastre, Ana Claudia Pereira, Daniela Martins-Mendes, Pedro Barata, Pilar Baylina, Ruben Fernandes
Summary: This study demonstrates that pioglitazone enhances adipocyte differentiation and secretome production, making it an excellent model for studying adiposity. The study also proposes an improved method for adipocyte secretome production, which can be used for experimental biology studies to understand the molecular mechanisms underlying the influence of adiposity on other cells.
Article
Nutrition & Dietetics
Elisabetta Melloni, Silvia Grassilli, Arianna Romani, Erika Rimondi, Annalisa Marcuzzi, Enrico Zauli, Paola Secchiero, Guglielmo Paganetto, Alessandra Guerrini, Gianni Sacchetti, Massimo Tacchini
Summary: Convolvulus pluricaulis is a commonly used Indian herb in Ayurvedic medicine known for its neuroprotective and neuroinflammatory action. Recent studies have shown its involvement in lipidic and glucidic metabolism, particularly in the control of hyperlipidaemia and diabetic conditions. It has been found to promote adipocyte differentiation and regulate glucose metabolism through the modulation of key regulators such as PPAR gamma and GLUT-4. Additionally, it exhibits anti-inflammatory effects by downregulating cytokines associated with insulin resistance and glucose intolerance. These findings suggest that Convolvulus pluricaulis could have potential benefits in glycemia and may be used as an adjunctive treatment for diabetes or for better glucose control.
Article
Integrative & Complementary Medicine
Eunbi Koh, Boram Kim, Kyungoh Choi
Summary: The study found that Torreya nucifera seed oil (TNSO) can promote adipocyte differentiation, increase intracellular lipid accumulation, and improve adipocyte function by activating adipogenic gene expression and PPAR gamma, STAT3 pathways.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Pharmacology & Pharmacy
Na-Yeon Kim, Chae-Min Lim, Hyo-Min Park, Jinju Kim, Thu-Huyen Pham, Young Yang, Hee Pom Lee, Jin Tae Hong, Do-Young Yoon
Summary: In this study, the researchers demonstrated the adipogenic effects of MMPP in vitro through regulating PPAR gamma transcriptional activity. MMPP directly binds to PPAR gamma and enhances the expression of adipogenic markers. Additionally, MMPP improves insulin sensitivity and glucose uptake. Therefore, MMPP may be a potential drug for type 2 diabetes and metabolic disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Dandan Zhao, Yanyun Pan, Na Yu, Ying Bai, Rufeng Ma, Fangfang Mo, Jiacheng Zuo, Beibei Chen, Qiangqiang Jia, Dongwei Zhang, Jiaxian Liu, Guanjian Jiang, Sihua Gao
Summary: Accumulating evidence suggests that curcumin promotes the adipogenic differentiation of preadipocytes and enhances mitochondrial oxygen consumption in 3T3-L1 mature adipocytes by regulating the expression of UCP1, PRDM16, PPAR gamma, and PGC-1 alpha.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Junjie Yue, Caiting Sun, Jinyuan Tang, Qiyuan Zhang, Mengjie Lou, Hongwen Sun, Lianying Zhang
Summary: 2-Ethylhexyl diphenyl phosphate (EHDPP), a commonly used flame retardant and food packaging material, exhibits high lipophilicity and bioaccumulation properties, primarily targeting adipocytes. The toxicity of EHDPP on preadipocytes and the underlying mechanism have not been fully understood. This study identified 7 differentially expressed miRNAs in 3T3-L1 preadipocytes exposed to EHDPP, with miR-155-5p being the most significantly down-regulated miRNA. Inhibition of miR-155-5p promoted adipocyte differentiation, while its overexpression counteracted EHDPP-induced adipogenesis.
Article
Biochemistry & Molecular Biology
Vaikundamoorthy Ramalingam, Inho Hwang
Summary: The study demonstrated that ZVZ nanoparticles can effectively induce adipogenesis and increase lipid accumulation in 3T3-L1 cells, while regulating cell differentiation by upregulating the expression of key genes.
PROCESS BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Eun-Ok Lee, Hee-Kyoung Joo, Yu-Ran Lee, Sungmin Kim, Kwon-Ho Lee, Sang-Do Lee, Byeong-Hwa Jeon
Summary: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is involved in DNA repair and redox regulation. It inhibits adipocyte differentiation by regulating adipogenic transcription factors, suggesting it as a potential therapeutic target for regulating adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shan Zhang, Yanru You, Yachong Li, Hairui Yuan, Jie Zhou, Lijie Tian, Ying Liu, Baoli Wang, Endong Zhu
Summary: Foxk1 promotes adipocyte differentiation by facilitating nuclear translocation and upregulating the transcriptional activity of the Ppar gamma 2 promoter.
Article
Food Science & Technology
Y. Xie, H. F. Berntsen, K. E. Zimmer, E. Ropstad, S. Verhaegen, L. Connolly
Summary: This study found that human exposure to persistent organic pollutants (POPs) may contribute to obesogenic effects. The addition of luteolin, a flavone compound, to a human relevant mixture of POPs in the laboratory was able to inhibit adipocyte formation and intracellular lipid accumulation.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Cell Biology
Xin Lv, Jun Qiu, Tao Hao, Haoran Zhang, Haiping Jiang, Yang Tan
Summary: The study demonstrated that TSA inhibited adipogenesis in 3T3-L1 preadipocytes by activating the AMPK pathway, leading to decreased lipid accumulation. Furthermore, TSA was also able to reverse the weight gain and adipose tissue increase induced by a high-fat diet in obese mouse models.
Article
Biochemistry & Molecular Biology
Mi-Jin Oh, Hye-Bin Lee, Guijae Yoo, Miri Park, Chang-Hyun Lee, Inwook Choi, Ho-Young Park
Summary: The study evaluated the anti-obesity effect of water-soluble red pepper leaf extract on adipocytes and HFD-fed mice. The findings showed that the extract reduced fat accumulation and improved intestinal health, suggesting its potential in preventing obesity.
Article
Food Science & Technology
Young-Sil Lee, Sun-Sil Choi, Takayuki Yonezawa, Toshiaki Teruya, Je-Tae Woo, Hyo Jung Kim, Byung-Yoon Cha
FOOD SCIENCE AND BIOTECHNOLOGY
(2015)
Article
Food Science & Technology
Ji-Won Lee, Midori Asai, Sang-Kyung Jeon, Tadahiro Iimura, Takayuki Yonezawa, Byung-Yoon Cha, Je-Tae Woo, Akira Yamaguchi
MOLECULAR NUTRITION & FOOD RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Hyo Jung Kim, Takayuki Yonezawa, Toshiaki Teruya, Je-Tae Woo, Byung-Yoon Cha
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2015)
Article
Chemistry, Medicinal
Motoyasu Minami, Takako Mori, Takayuki Yonezawa, Yukiko Saito, Toshiaki Teruya, Je-Tae Woo
JOURNAL OF NATURAL MEDICINES
(2018)
Article
Immunology
Yan Weng, Natsumi Mizuno, Jiangxu Dong, Ryosuke Segawa, Takayuki Yonezawa, Byung Yoon Cha, Je-Tae Woo, Takahiro Moriya, Masahiro Hiratsuka, Noriyasu Hirasawa
INTERNATIONAL IMMUNOPHARMACOLOGY
(2018)
Article
Plant Sciences
Yuji Mitani, Kazuhiro Satake, Megumi Tsukamoto, Ichiro Nakamura, Onat Kadioglu, Toshiaki Teruya, Takayuki Yonezawa, Cha Byung-Yoon, Thomas Efferth, Woo Je-Tae, Hiroshi Nakagawa
Article
Biochemistry & Molecular Biology
Byung Geun Ha, Takayuki Yonezawa, Myoung Jin Son, Je Tae Woo, Shinsuke Ohba, Ung-Il Chung, Kazumi Yagasaki
Article
Biochemistry & Molecular Biology
Sun Hee Cheong, Keisuke Furuhashi, Katsuki Ito, Masato Nagaoka, Takayuki Yonezawa, Yutaka Miura, Kazumi Yagasaki
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2014)
Article
Cell Biology
Yan Weng, Jingwen Wang, Zhifu Yang, Miaomiao Xi, Jialin Duan, Chao Guo, Ying Yin, Ryosuke Segawa, Takahiro Moriya, Takayuki Yonezawa, Byung Yoon Cha, Je-Tae Woo, Aidong Wen, Noriyasu Hirasawa
CELLULAR SIGNALLING
(2019)
Article
Chemistry, Multidisciplinary
Haruhisa Kikuchi, Kosuke Kawai, Yota Nakashiro, Takayuki Yonezawa, Kumi Kawaji, Eiichi. N. Kodama, Yoshiteru Oshima
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Pharmacology & Pharmacy
Ryosuke Segawa, Mika Shiraki, Shiori Sudo, Kenichi Shigeeda, Taiji Saito, Natsumi Mizuno, Takahiro Moriya, Takayuki Yonezawa, Je-Tae Woo, Masahiro Hiratsuka, Noriyasu Hirasawa
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Tomoe Tsuboi, Rui Lu, Takayuki Yonezawa, Akio Watanabe, Je-Tae Woo, Sumiko Abe-Dohmae, Shinji Yokoyama
Article
Biotechnology & Applied Microbiology
Noriyuki Natsume, Takayuki Yonezawa, Je-Tae Woo, Toshiaki Teruya
Summary: Pinocembrin isolated from the traditional plant Alpinia zerumbet in Okinawa, Japan, showed enhanced ALP activity and mineralization, and increased mRNA expression of osteoblast-related genes. Pinocembrin may increase BMP-2 expression via ER, promoting osteoblast specific genes expression and mineralization through Smad-dependent and independent pathways. This suggests that pinocembrin has bone anabolic effects and may be useful for the prevention and treatment of bone metabolic diseases such as osteoporosis.
Article
Biochemistry & Molecular Biology
Akio Watanabe, Marilia Oliveira de Almeida, Yusuke Deguchi, Ryuzo Kozuka, Caroline Arruda, Andresa Aparecida Berretta, Jairo Kenupp Bastos, Je-Tae Woo, Takayuki Yonezawa
Summary: Baccharin, a major component of Brazilian green propolis, promotes adipocyte differentiation by increasing lipid accumulation and glucose uptake through activation of PPAR gamma. In diabetic ob/ob mice, intraperitoneal administration of baccharin significantly improved blood glucose levels. These results suggest that baccharin has a hypoglycemic effect on glucose metabolic disorders, such as type 2 diabetes mellitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Noriyuki Natsume, Takayuki Yonezawa, Yukiko Saito, Je-Tae Woo, Toshiaki Teruya
Summary: The study revealed that isonymphaeol B and 3'-geranyl naringenin promote glucose uptake and AMPK phosphorylation in skeletal muscle cells, leading to increased levels of GLUT1 protein, indicating potential benefits for glucose metabolism and suggesting their potential as lead candidates for antidiabetic drug development.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.