Article
Biochemistry & Molecular Biology
Chinami Matsumoto, Hitomi Sekine, Nana Zhang, Sachiko Mogami, Naoki Fujitsuka, Hiroshi Takeda
Summary: Chemotherapy-induced sarcopenia is a negative prognostic factor that affects postoperative complications and quality of life in cancer patients. Cisplatin, a commonly used chemotherapy drug, causes skeletal muscle loss by affecting mitochondrial function and activating muscle-specific ubiquitin ligases Atrogin-1 and muscle RING finger 1 (MuRF1). Although p53 has been implicated in muscle atrophy, it is unclear if it plays a role in cisplatin-induced atrophy. This study investigated the effect of a p53-specific inhibitor, pifithrin-alpha (PFT-a), on cisplatin-induced muscle atrophy in C2C12 myotubes. The results showed that cisplatin increased p53 levels and upregulated the expression of p53 target genes in C2C12 myotubes. PFT-a reduced reactive oxygen species production, mitochondrial dysfunction, and the increase in the Bax/Bcl-2 ratio induced by cisplatin. However, PFT-a did not ameliorate the decrease in muscle protein synthesis. Overall, this study suggests that cisplatin-induced muscle degradation is p53-dependent, but p53 has minimal involvement in the reduction of muscle protein synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Cong Wu, Zhiming Shen, Yi Lu, Fei Sun, Hongcan Shi
Summary: This study demonstrates that Fe3O4 nanoparticles can induce ferroptosis in macrophages and elucidates the molecular mechanisms involved in this process. It provides important theoretical insights into the impact of nanoparticles on macrophages and their associated biotoxicity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Mingyuan Wang, Qiong Huang, Min Liu, Tianjiao Zhao, Xiangping Song, Qiaohui Chen, Yongqi Yang, Yayun Nan, Zerun Liu, Yuntao Zhang, Wei Wu, Kelong Ai
Summary: Increased incidence of inflammatory bowel disease (IBD) has negatively impacted patients' quality of life. The authors developed a novel oral nanomedicine (OPEN) that inhibits excessive intestinal epithelial cell apoptosis, providing a new strategy for comprehensive IBD therapy.
ADVANCED MATERIALS
(2023)
Article
Cell Biology
Chunyun Zhang, Yingjie Guan, Jianan Zou, Xu Yang, Georgia Bayliss, Shougang Zhuang
Summary: This study reveals the role of MLL1 in acute kidney injury (AKI) induced by cisplatin. The inhibition of the MLL1/WDR5 complex using MM102 improved renal function, attenuated tubular injury and apoptosis, and suppressed the phosphorylation of p53 and the decrease of E-cadherin expression. MM102 also effectively inhibited the DNA damage response triggered by cisplatin.
CELL DEATH & DISEASE
(2022)
Article
Urology & Nephrology
Chen Yuqiang, Zhang Lisha, Wen Jiejun, Xue Qin, Wang Niansong
Summary: This study suggests that p53 may be a therapeutic target for AKI caused by glycerol. Pretreatment of pifithrin-alpha or using it as a rescue therapy can effectively protect against severe injury.
Article
Cell Biology
Yinwu Bao, Mengqiu Bai, Huanhuan Zhu, Yuan Yuan, Ying Wang, Yunjing Zhang, Junni Wang, Xishao Xie, Xi Yao, Jianhua Mao, Xianghui Fu, Jianghua Chen, Yi Yang, Weiqiang Lin
Summary: Tet2 plays a renal protective role in AKI by regulating metabolic and inflammatory responses through the PPAR signaling pathway.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Chang Woo Han, Han Na Lee, Mi Suk Jeong, So Young Park, Se Bok Jang
Summary: PUMA is a direct target in p53-mediated apoptosis and can trigger mitochondrial apoptosis through transcription-dependent and independent mechanisms. Experimental results demonstrate the interaction between PUMA peptide and the DNA binding domain of p53 inhibits the growth of a lung cancer cell line. These findings contribute to understanding the mechanism responsible for p53-mediated apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Mohamed S. Abdel-Bakky, Anas S. A. Aldakhili, Hussein M. Ali, Ali Y. Babiker, Ahmad H. Alhowail, Salman A. A. Mohammed
Summary: This study compares the effects of prophylaxis with fondaparinux and treatment with alteplase in ameliorating cisplatin-induced acute renal failure. The results indicate that fondaparinux may have a positive effect in improving kidney injury, while alteplase is less effective.
Article
Multidisciplinary Sciences
Suisui Hao, Jingshan Tong, Anupma Jha, Denise Risnik, Darleny Lizardo, Xinyan Lu, Ajay Goel, Patricia L. Opresko, Jian Yu, Lin Zhang
Summary: Synthetic lethality can be used to target oncogenic drivers in cancer, and in this study, it was found that WRN helicase is required for the survival of MSI CRC cells. Depletion of WRN induces p53 and PUMA, leading to apoptosis in MSI CRC cells. The vulnerability of MSI CRCs to WRN loss is mediated by p53/PUMA-dependent apoptosis. WRN depletion or treatment with ML216 suppresses the growth of MSI CRCs in vitro and in vivo in a p53/PUMA-dependent manner.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Zhenhao Chen, Jian Song, Lin Xie, Guangyu Xu, Chaojun Zheng, Xinlei Xia, Feizhou Lu, Xiaosheng Ma, Fei Zou, Jianyuan Jiang, Hongli Wang
Summary: Circular RNAs (circRNAs) play a role in intervertebral disc degeneration (IVDD) and are modified with N6-methyladenosine (m6A). We found that circGPATCH2L, which has low m6A methylation level, is upregulated in degenerative nucleus pulposus tissues. CircGPATCH2L acts as a protein decoy for TRIM28, inhibiting P53 degradation and contributing to IVDD progression. M6A-methylated circGPATCH2L is recognized and cleaved by a YTHDF2-RPL10-RNase P/MRP complex, maintaining the physiological state of nucleus pulposus cells.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biology
Ashfaq Ahmad
Summary: This study found that the H2S donor NaHS could alleviate the severity of renal ischemia reperfusion injury by improving oxidative stress and reducing the concentration of inflammatory molecules, thus protecting kidney function.
Article
Multidisciplinary Sciences
Kunihiro Nakai, Minato Umehara, Atsushi Minamida, Hiroko Yamauchi-Sawada, Yasuto Sunahara, Yayoi Matoba, Natsuko Okuno-Ozeki, Itaru Nakamura, Tomohiro Nakata, Aya Yagi-Tomita, Noriko Uehara-Watanabe, Tomoharu Ida, Noriyuki Yamashita, Michitsugu Kamezaki, Yuhei Kirita, Eiichi Konishi, Hiroaki Yasuda, Satoaki Matoba, Keiichi Tamagaki, Tetsuro Kusaba
Summary: Streptozotocin (STZ) is an anti-cancer drug used to treat neuroendocrine tumors (NETs). It enters pancreatic beta-cells or proximal tubular epithelial cells through GLUT2. This study demonstrated the cytotoxic effects of STZ on kidney cells and identified DNA damage and p53 signaling as underlying mechanisms. Inhibition of p53 and SGLT2 mitigated kidney injury caused by STZ, but the cytotoxic effects on pancreatic beta-cells were not affected. These findings suggest the potential use of SGLT2 inhibitors as preventive treatments for kidney injury in NET patients treated with STZ.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Qian Zhou, Jinyao Yin, Jingwen Tan, Shuting Li, Chenglan Jiang, Yuefeng He
Summary: This study aimed to investigate the effects and mechanisms of inorganic arsenic and its metabolites on the expression of PUMA. The results showed that NaAsO2 caused overexpression of PUMA, as well as increased phosphorylation and acetylation of P53. These findings suggest a role of PUMA upregulation in P53 phosphorylation and acetylation, leading to apoptosis.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Binbin Cui, Xiying Hou, Mengjun Liu, Qing Li, Chao Yu, Shenglei Zhang, Yi Wang, Jun Wang, Shougang Zhuang, Feng Liu
Summary: This study reveals that SMYD2 plays a critical role in cisplatin-induced acute kidney injury. The specific inhibitor AZ505 suppresses SMYD2 expression, improving kidney function and reducing kidney damage. AZ505 exerts its protective effects through mechanisms including reducing cell injury and apoptosis, inhibiting inflammation, and promoting cell proliferation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Hong-Chieh Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Chiung-Yin Huang, Ko-Ting Chen, Ya-Jui Lin, Hsiao-Wei Cheng, Yi-Rou Chen, Hsiang-Tsui Wang
Summary: Combination treatment of TMZ and VPA in GBM patients can be beneficial for survival, depending on the p53 gene status. In cellular experiments, VPA enhances the antineoplastic effect of TMZ by promoting p53 activation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
