Article
Cardiac & Cardiovascular Systems
Shuhei Toba, Stephen P. Sanders, Kimberlee Gauvreau, John E. Mayer, Chrystalle Katte Carreon
Summary: The study found that patients with ccTGA with IVS or DTGA with IVS after PAB for retraining showed significant cardiomyocyte hypertrophy but lower capillary density, indicating a potential pathological basis for mLV dysfunction after anatomic repair.
ANNALS OF THORACIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Eveliina Halmetoja, Irina Nagy, Zoltan Szabo, Tarja Alakoski, Raisa Yrjola, Laura Vainio, Eliina Viitavaara, Ruizhu Lin, Lea Rahtu-Korpela, Seppo Vainio, Risto Kerkela, Johanna Magga
Summary: Wnt11 is involved in early cardiac development and left ventricular compaction, but its role in postnatal cardiac maturation and response to stress in the adult heart is not well understood. This study found that Wnt11 deficiency does not affect cardiomyocyte proliferation or maturation, but does lead to enlargement of the heart. Additionally, Wnt11 deficiency does not exacerbate cardiac hypertrophy or remodeling in response to pressure overload.
Article
Multidisciplinary Sciences
Patricia Goncalves-Rodrigues, Daniela Miranda-Silva, Adelino F. Leite-Moreira, Ines Falcao-Pires
Summary: The study describes a rodent model to investigate left ventricular (LV) reverse remodeling (RR) through aortic banding and debanding surgeries. The surgical procedures showed high survival rates with improved cardiac function and reduced ventricular hypertrophy and fibrosis post-debanding.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Peripheral Vascular Disease
Katarzyna Hackert, Susanne Homann, Shakila Mir, Arne Beran, Simone Gorressen, Florian Funk, Jens W. Fischer, Maria Grandoch, Joachim P. Schmitt
Summary: 4-MU can attenuate inflammation and extracellular matrix remodeling in pressure-overloaded myocardium by reducing both resident and invading cardiac macrophages, leading to reduced myocardial fibrosis. Additionally, 4-MU also reduces left ventricular hypertrophy and increases cardiac output after TAC surgery.
Review
Cell Biology
Xin Liu, Guo-Ping Shi, Junli Guo
Summary: Pressure overload and heart failure are major causes of cardiovascular morbidity and mortality, where innate immune cells and inflammatory mediators play crucial roles. Different innate immune cells, including mast cells, macrophages, monocytes, neutrophils, dendritic cells, eosinophils, and natural killer T cells, exhibit varying levels of activity in these pathological processes, with some exacerbating cardiodysfunction and others displaying cardioprotective activities. Overall, immune regulation of cardiac innate immune cells holds promise as a therapeutic approach in experimental cardiac disease treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Fang-fang Ren, Lin Zhao, Xian-yun Jiang, Jing-jing Zhang, Jia-min Gou, Xiao-yu Yu, Shu-jin Wu, Lei Li
Summary: Apoptosis, or programmed cell death, plays a critical role in the development of heart failure. Sphingosylphosphorylcholine (SPC), a bioactive sphingolipid, has been shown to inhibit apoptosis in myofibroblasts, non-muscle cells in the heart. In this study, the researchers investigated the role of the SPC receptor, calmodulin (CaM), in cardiomyocyte apoptosis and the associated signaling pathways. They found that SPC administration improved survival rate, cardiac hypertrophy, and cardiac fibrosis in mice with pressure overload-induced heart failure. In cardiomyocytes, SPC treatment inhibited cardiomyocyte hypertrophy, fibroblast-to-myofibroblast transition, and cell apoptosis. This was accompanied by reduced levels of pro-apoptotic proteins and phosphorylation of CaM, JNK, and p38, as well as increased levels of a cardiomyocyte-protective protein. The protective effect of SPC was annulled by a compound that increased CaM function. The researchers also demonstrated that SPC-mediated inhibition of cardiomyocyte apoptosis involved the regulation of p38 and JNK phosphorylation, which was downstream of CaM. These findings provide new evidence for SPC regulation of cardiomyocyte apoptosis and suggest it as a potential therapeutic target for cardiac remodeling following stress overload.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pharmacology & Pharmacy
O. Caglar Yilmaz, Selcuk Ozkan
Summary: This study found a high prevalence of masked hypertension in patients with unexplained left ventricular hypertrophy (ULVH), highlighting the importance of screening with ambulatory blood pressure monitoring. Left ventricular mass index was significantly higher in masked hypertensive ULVH patients compared to normotensive ULVH and control subjects.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Yuki Ikeno, Van Thi Thanh Truong, Akiko Tanaka, Siddharth K. Prakash
Summary: This study aimed to investigate the long-term effect of surgical aortic repair with prostheses on postsurgical left ventricular (LV) mass. The results showed that LV mass index may significantly decrease over time after the aortic repair, but the degree of reduction varies. Presentation due to acute aortic dissection and baseline LV mass index were significant predictors of LV mass reduction.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, Research & Experimental
Ana B. Salido-Medina, Aritz Gil, Victor Exposito, Fernando Martinez, Juan M. Redondo, Maria A. Hurle, J. Francisco Nistal, Raquel Garcia
Summary: This study investigated the therapeutic potential of BMP7-based peptides as cardioprotective drugs in the context of aortic stenosis. The results demonstrated that these peptides attenuated remodeling-related genes, alleviated structural damage, and improved LV dysfunction in animal models. They also showed potential in inhibiting hypertrophic gene program and collagen transcriptional activation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cardiac & Cardiovascular Systems
Katharina Schimmel, Kenzo Ichimura, Sushma Reddy, Francois Haddad, Edda Spiekerkoetter
Summary: Myocardial fibrosis is a process of extracellular matrix remodeling in response to cardiac stress. It can be classified into replacement fibrosis and reactive fibrosis. Reactive fibrosis develops over time in chronic pressure overload and affects the function of the left or right ventricle. Reactive fibrosis in the left ventricle is associated with the development and progression of heart failure, while reactive fibrosis in the right ventricle is common in conditions such as pulmonary arterial hypertension. Understanding the differences and common characteristics of extracellular matrix remodeling in the left and right ventricles under pressure overload is crucial for developing new approaches to treat heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Ze-Yan Yu, Hutao Gong, Jianxin Wu, Yun Dai, Scott H. Kesteven, Diane Fatkin, Boris Martinac, Robert M. Graham, Michael P. Feneley
Summary: Activation of Gq-coupled receptors and calcineurin are necessary for neurohumorally mediated left ventricular hypertrophy (LVH), while LVH induced by mechanical pressure overload (TAC) is associated with activation of the CaMKII-HDAC4-MEF2 pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ming-Kui Zhang, Li-Na Li, Hui Xue, Xiu-Jie Tang, He Sun, Qing-Yu Wu
Summary: This study aimed to investigate left ventricle reverse remodeling (LVRR) and outcomes in chronic aortic regurgitation patients with severe dilated left ventricle and dysfunction after aortic valve replacement (AVR). The results showed that left ventricle remodeling after AVR was an important predictor for major adverse cardiac events (MACE), and patients with no LV remodeling may not benefit from AVR.
JOURNAL OF CARDIOTHORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Menglong Wang, Mengmeng Zhao, Junping Yu, Yao Xu, Jishou Zhang, Jianfang Liu, Zihui Zheng, Jing Ye, Zhen Wang, Di Ye, Yongqi Feng, Shuwan Xu, Wei Pan, Cheng Wei, Jun Wan
Summary: This study investigated the effects of the selective NLRP3 inhibitor MCC950 on heart failure (HF) induced by pressure overload in obese mice and its metabolic mechanism. The results showed that MCC950 improved cardiac hypertrophy, fibrosis, and inflammation in obese mice. It also promoted M2 macrophage infiltration and regulated fatty acid and glucose uptake and utilization. Additionally, MCC950 affected the phosphorylation of AKT and AMPK in obese mice with HF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kenichiro Suwa, Amir Ali Rahsepar, Julia Geiger, Ryan Dolan, Ahmadreza Ghasemiesfe, Alex J. Barker, Jeremy D. Collins, Michael Markl, James C. Carr
Summary: In patients with aortic valve dysfunction, the presence of bicuspid aortic valve (BAV), aortic stenosis (AS), and regurgitation (AR) is associated with significant morphological remodeling in the left ventricle (LV).
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Physiology
Jairo Montemor Augusto Silva, Ednei Luiz Antonio, Luis Felipe Neves Dos Santos, Andrey Jorge Serra, Regiane Santos Feliciano, Jose Antonio Silva Junior, Silvia Saiuli Miki Ihara, Paulo Jose Ferreira Tucci, Valdir Ambrosio Moises
Summary: This study aimed to evaluate the morphological, functional, and gene expression parameters of the right ventricle (RV) in rats subjected to pulmonary artery banding (PAB) and analyze the influence of RV remodeling on left ventricular (LV) geometry, histology, gene expression, and functional performance. The results showed that PAB induced RV remodeling with hypertrophy, accompanied by alterations in gene expression and fibrosis. Additionally, the study revealed histological and gene expression changes in the LV that were concurrent with the alterations in the RV.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Elise Roussel, Marie-Claude Drolet, Elisabeth Walsh-Wilkinson, Wahiba Dhahri, Dominic Lachance, Suzanne Gascon, Otman Sarrhini, Jacques A. Rousseau, Roger Lecomte, Jacques Couet, Marie Arsenault
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Multidisciplinary Sciences
Marie-Claude Drolet, Vincent Desbiens-Brassard, Elise Roussel, Veronique Tu, Jacques Couet, Marie Arsenault
Article
Multidisciplinary Sciences
Alexandre P. Garneau, Andree-Anne Marcoux, Micheline Noel, Rachelle Frenette-Cotton, Marie-Claude Drolet, Jacques Couet, Richard Lariviere, Paul Isenring
Article
Multidisciplinary Sciences
Catherine Beaumont, Elisabeth Walsh-Wilkinson, Marie-Claude Drolet, Elise Roussel, Marie Arsenault, Jacques Couet
SCIENTIFIC REPORTS
(2017)
Article
Endocrinology & Metabolism
Sophie Carter, Stephanie Miard, Alexandre Caron, Sandrine Salle-Lefort, Philippe St-Pierre, Fernando Forato Anhe, Emilie Lavoie-Charland, Pascale Blais-Lecours, Marie-Claude Drolet, Julie S. Lefebvre, Julie Lacombe, Yves Deshaies, Jacques Couet, Mathieu Laplante, Mathieu Ferron, Yohan Bosse, Andre Marette, Denis Richard, David Marsolais, Frederic Picard
Article
Cardiac & Cardiovascular Systems
Dominic Lachance, Wahiba Dhahri, Marie-Claude Drolet, Elise Roussel, Suzanne Gascon, Otman Sarrhini, Jacques A. Rousseau, Roger Lecomte, Marie Arsenault, Jacques Couet
BMC CARDIOVASCULAR DISORDERS
(2014)
Article
Cardiac & Cardiovascular Systems
Wahiba Dhahri, Marie-Claude Drolet, Elise Roussel, Jacques Couet, Marie Arsenault
BMC CARDIOVASCULAR DISORDERS
(2014)
Article
Biochemistry & Molecular Biology
Elise Roussel, Marie-Claude Drolet, Anne-Marie Lavigne, Marie Arsenault, Jacques Couet
Article
Multidisciplinary Sciences
Elisabeth Walsh-Wilkinson, Marie-Claude Drolet, Charlie Le Houillier, Eve-Marie Roy, Marie Arsenault, Jacques Couet
Article
Multidisciplinary Sciences
Elisabeth Walsh-Wilkinson, Catherine Beaumont, Marie-Claude Drolet, Eve-Marie Roy, Charlie Le Houillier, Jonathan Beaudoin, Marie Arsenault, Jacques Couet
Article
Cardiac & Cardiovascular Systems
Elisabeth Walsh-Wilkinson, Marie-Claude Drolet, Marie Arsenault, Jacques Couet
BMC CARDIOVASCULAR DISORDERS
(2020)
Article
Cardiac & Cardiovascular Systems
Ons Marsit, Marie-Annick Clavel, Claudia Cote-Laroche, Sandra Hadjadj, Marc-Andre Bouchard, Mark D. Handschumacher, Marine Clisson, Marie-Claude Drolet, Marie-Chloe Boulanger, Dae-Hee Kim, J. Luis Guerrero, Philipp Emanuel Bartko, Jacques Couet, Marie Arsenault, Patrick Mathieu, Philippe Pibarot, Elena Aikawa, Joyce Bischoff, Robert A. Levine, Jonathan Beaudoin
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Multidisciplinary Sciences
Elisabeth Walsh-Wilkinson, Marie Arsenault, Jacques Couet
Summary: The study found that isoproterenol negatively affected left ventricular function in male and female mice, reducing ejection fraction and global and segmental strain. Male mice showed more severe modulation in the LV posterior segments, while both anterior and posterior wall segments were impacted in females. Although diastolic function parameters returned to normal after cessation of isoproterenol, LV dilation and decreased ejection fraction persisted in males even 17 weeks post-treatment.
Article
Cardiac & Cardiovascular Systems
Elisabeth Walsh-Wilkinson, Mohamed Lamine Aidara, Audrey Morin-Grandmont, Sara-Eve Thibodeau, Juliette Gagnon, Mathieu Genest, Marie Arsenault, Jacques Couet
Summary: Age, hypertension, and female sex are risk factors in the development of heart failure with preserved ejection fraction. In this study, the response of the left ventricle (LV) to aging and angiotensin II infusion was investigated using echocardiography in male and female mice. The results showed that LV strain and strain rate levels were higher in young females compared to males. Aging was associated with concentric LV remodeling and a decrease in LV strain and strain rate. Gonadectomy and angiotensin II infusion also had significant effects on LV parameters.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Physiology
Catherine Beaumont, Elisabeth Walsh-Wilkinson, Marie-Claude Drolet, Elise Roussel, Nicolas Melancon, Emile Fortier, Genevieve Harpin, Jonathan Beaudoin, Marie Arsenault, Jacques Couet
PHYSIOLOGICAL REPORTS
(2019)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.