Article
Biochemistry & Molecular Biology
Sarah Thompson, Chong Yun Pang, Krishna Mohan Sepuru, Seppe Cambier, Thomas P. Hellyer, Jonathan Scott, A. John Simpson, Paul Proost, John A. Kirby, Krishna Rajarathnam, Neil S. Sheerin, Simi Ali
Summary: Chemokine CXCL8 plays a crucial role in human immune response by mediating neutrophil migration and activation at sites of infection and injury. This study demonstrates that peroxynitrite can nitrate CXCL8, leading to impaired neutrophil migration and activation. The nitrated chemokine showed reduced ability to induce neutrophil migration in vitro and failed to promote leukocyte recruitment in vivo due to impaired receptor signaling and binding to glycosaminoglycans. The presence of nitrated CXCL8 was detected in bronchoalveolar lavage samples from patients with pneumonia, providing the first direct evidence of chemokine nitration in human pathophysiology.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Forough Torabi, Jayakumar Vadakekolathu, Rebecca Wyatt, Pia Leete, Melissa A. Tombs, Carolyn C. Richardson, David J. Boocock, Mark D. Turner, Noel G. Morgan, Sarah J. Richardson, Michael R. Christie
Summary: Morphological studies of pancreas samples from young people with recent-onset type 1 diabetes have identified distinct patterns of immune cell infiltration, suggesting two age-associated endotypes of the disease. This study aimed to investigate whether these endotypes are associated with differences in immune cell activation and cytokine secretion by analyzing gene expression in pancreatic tissue.
Article
Cell Biology
Nastaran Tarban, Albert Balint Papp, David Deak, Peter Szentesi, Hajnalka Halasz, Andreas Patsalos, Laszlo Csernoch, Zsolt Sarang, Zsuzsa Szondy
Summary: Skeletal muscle regeneration is a complex process that involves inflammatory responses and the role of adenosine A3 receptors in this process was investigated. Loss of A3 receptors resulted in a stronger initial inflammatory response, but also accelerated muscle tissue repair and fiber growth.
CELL DEATH & DISEASE
(2023)
Article
Allergy
Tao Liu, Nora A. Barrett, Jun Nagai, Juying Lai, Chunli Feng, Joshua A. Boyce
Summary: The study showed that LTD4 can functionally antagonize LTC4 signaling at CysLT(2)R, thereby blocking related inflammatory responses. In addition, LTD4 can also mitigate LTC4-mediated lung inflammation, as evidenced by a decrease in levels of IL-33, IL-4, IL-5, and IL-13.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hyeong Bin Rheem, Hyunwoo Choi, Seoin Yang, Sol Han, Su Yeon Rhee, Hyeongseop Jeong, Kyung-Bok Lee, Yeji Lee, In-San Kim, Hojae Lee, Insung S. S. Choi
Summary: Chemotactic movement and direction of Jurkat T cells have been chemically controlled by constructing cell-in-catalytic-coat structures in single-cell nanoencapsulation. The nanobiohybrid cytostructures, called Jurkat([Lipo_GOx]), exhibit controllable, redirected chemotactic movement in response to d-glucose gradients, opposite to the positive-chemotaxis direction of uncoated Jurkat cells. This work provides an innovative chemical tool for bioaugmenting living cells through catalytic cell-in-coat structures.
Article
Immunology
Ira S. S. Rostevanov, Batya Betesh-Abay, Ahmad Nassar, Elina Rubin, Sarit Uzzan, Jacob Kaplanski, Linoy Biton, Abed N. N. Azab
Summary: This study aimed to examine the behavioral effects and inflammatory mediator levels of chronic MTK treatment in male and female rats. The results suggest that MTK may be associated with select beneficial behavioral outcomes and differentially affects male vs. female rats in respect to brain inflammatory mediators.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiao Tang, Tarvi Teder, Bengt Samuelsson, Jesper Z. Haeggstrom
Summary: The IRE1 alpha inhibitor, KIRA6, can block leukotriene biosynthesis in human phagocytes activated with LPS plus fMLP or Tg. This inhibition is independent of IRE1 alpha and is associated with the reduction of p38 and ERK phosphorylation, as well as cPLA(2)alpha phosphorylation. The interaction of KIRA6 with p38 may explain its immune-modulating properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Eva Knuplez, Melanie Kienzl, Athina Trakaki, Rudolf Schicho, Akos Heinemann, Eva M. Sturm, Gunther Marsche
Summary: Miltefosine has a strong modulatory activity in regulating eosinophilic inflammation both in vitro and in vivo, showing potential efficacy in treating allergic diseases and other eosinophil-associated disorders. This may lead to important questions regarding the immunomodulatory effect of miltefosine in patients treated for leishmania infections.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Nina Li, Hoomann Mirzakhani, Alexander Kiefer, Julia Koelle, Tytti Vuorinen, Manfred Rauh, Zuqin Yang, Susanne Krammer, Paraskevi Xepapadaki, Anna Lewandowska-Polak, Heikki Lukkarinen, Nan Zhang, Barbara Stanic, Theodor Zimmermann, Marek L. Kowalski, Tuomas Jartti, Claus Bachert, Mubeccel Akdis, Nikolaos G. Papadopoulos, Benjamin A. Raby, Scott T. Weiss, Susetta Finotto
Summary: RANTES plays a critical role in allergic asthma and infection clearance by transitioning effector T cells and increasing IL-10 production, thus showing a therapeutic potential in resolving allergen-induced asthma.
Review
Immunology
Peter W. West, Silvia Bulfone-Paus
Summary: Mast cells exhibit heterogeneity in different tissues and their interactions with immune cells may be regulated by tissue-specific factors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Joseena Iype, Michaela Fux
Summary: This study focuses on the role of eosinophils and basophils in allergic diseases, suggesting their potential interaction and influence on each other in allergic inflammations.
Review
Biochemistry & Molecular Biology
Eva Knuplez, Eva Maria Sturm, Gunther Marsche
Summary: This study explores the important role of eosinophils in allergic inflammation through the production of lipid mediators, as well as their regulatory function in local immunity and repair. Targeting the complex network of lipid mediators offers a unique opportunity to modulate eosinophil activity without compromising other leukocytes and tissue-resident eosinophils.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sambor Grygorczuk, Piotr Czupryna, Justyna Dunaj, Anna Moniuszko-Malinowska, Renata Swierzbinska, Slawomir Pancewicz
Summary: In patients with neuroborreliosis, chemotactic cytokines for T lymphocytes are significantly upregulated in the cerebrospinal fluid, with associations to clinical parameters such as CSF lymphocyte counts and blood-brain barrier disruption. Different cytokines play distinct inflammatory roles in the course of neuroborreliosis.
Review
Immunology
Inge Jacobs, Matthias Ceulemans, Lucas Wauters, Christine Breynaert, Severine Vermeire, Bram Verstockt, Tim Vanuytsel
Summary: Eosinophils, a type of white blood cell, play a crucial role in gastrointestinal health and are increasingly being studied for their inflammatory and pro-fibrotic functions in inflammatory bowel disease and other chronic inflammatory conditions. Research focus is shifting towards innate immunity and understanding the inflammatory properties of eosinophils.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eugenia Marbach-Breitrueck, Nadine Rohwer, Carmen Infante-Duarte, Silvina Romero-Suarez, Dominika Labuz, Halina Machelska, Laura Kutzner, Nils Helge Schebb, Michael Rothe, Pallu Reddanna, Karsten H. Weylandt, Lothar H. Wieler, Dagmar Heydeck, Hartmut Kuhn
Summary: The Alox5-KI mice, expressing a mutant Alox5 enzyme, showed earlier disease onset and higher incidence rate in the experimental autoimmune encephalomyelitis (EAE) model compared to wildtype controls, but had similar outcomes in dextran sodium sulfate-induced colitis (DSS) and the chronic constriction nerve injury model (CCI). This suggests that these mutant mice respond differently in inflammation models compared to Alox5(-/-) mice in similar experimental settings.
Article
Multidisciplinary Sciences
Flavia Alves Verza, Vitor Bonetti Valente, Lia Kobayashi Oliveira, Giseli Mitsuy Kayahara, Marcelo Macedo Crivelini, Cristiane Furuse, Eder Ricardo Biasoli, Glauco Issamu Miyahara, Sandra Helena Penha Oliveira, Daniel Galera Bernabe
Summary: Social isolation stress may facilitate oral squamous cell carcinoma (OSCC) occurrence and tumor progression, accompanied by increased levels of inflammatory mediators. The study found that isolated rats had higher OSCC occurrence rates, tumor volumes, and levels of inflammatory mediators than grouped rats. The levels of TNF-alpha, IL-6, IL1-beta, and MCP-1 in tumors were positively correlated with OSCC growth.
Article
Multidisciplinary Sciences
Victor Gustavo Balera Brito, Mariana Sousa Patrocinio, Maria Carolina Linjardi Sousa, Ayna Emanuelli Alves Barreto, Sabrina Cruz Tfaile Frasnelli, Vanessa Soares Lara, Carlos Ferreira Santos, Sandra Helena Penha Oliveira
Summary: The study revealed the significant role of mast cells in periodontal disease-induced alveolar bone loss, especially in spontaneously hypertensive rats. Depletion of mast cells effectively inhibited alveolar bone loss caused by periodontal disease, reducing inflammatory status and mediator production, and decreasing osteoclast-related response markers.
Correction
Pharmacology & Pharmacy
Victor Gustavo Balera Brito, Mariana Sousa Patrocinio, Maria Carolina Linjardi, Ayna Emanuelli Alves Barreto, Sabrina C. T. Frasnelli, Vanessa Lara, Carlos Ferreira Santos, Sandra Helena Penha Oliveira
FRONTIERS IN PHARMACOLOGY
(2021)
Letter
Oncology
Ingrid da Silva Santos, Ligia Lavezo Ferreira, Saygo Tomo, Sandra Helena Penha de Oliveira, Eder Ricardo Biasoli, Daniel Galera Bernabe, Luisa Lina Villa, Glauco Issamu Miyahara
EUROPEAN JOURNAL OF CANCER PREVENTION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Caroline Miho Shibuya, Kellen Cristine Tjioe, Sandra Helena Penha Oliveira, Daniel Galera Bernabe
Summary: Propranolol (PPL) is effective against oral cancer cells and enhances standard-of-care. PPL exerts its effects by reducing cell viability and inhibiting the expression of key proteins. PPL also inhibits the migratory activity of oral cancer cells.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Oncology
Kellen Cristine Tjioe, Diovana Melo Cardoso, Sandra Helena Penha Oliveira, Daniel Galera Bernabe
Summary: This study found that the stress hormone NE induces resistance of oral cancer cells to cisplatin by acting on the ADRB/Akt/ABCG2 pathway. NE reduces the effectiveness of cisplatin on certain cell lines and achieves this resistance by pumping the drug out of the cell and inhibiting apoptosis.
ENDOCRINE-RELATED CANCER
(2022)
Article
Endocrinology & Metabolism
Fernanda Fernandes-Breitenbach, Melise Jacon Peres-Ueno, Luis Fernando Gadioli Santos, Victor Gustavo Balera Brito, Robson Chacon Castoldi, Mario Jeferson Quirino Louzada, Antonio Hernandes Chaves-Neto, Sandra Helena Penha Oliveira, Rita Cassia Menegati Dornelles
Summary: This study aimed to investigate the combined effects of oxytocin (OT) and strength training (ST) on the bone remodeling process in the femoral neck of Wistar rats during periestropause. The results showed that the combination of OT and ST had a greater impact on bone density, bone-related biomarkers, and mechanical properties compared to isolated interventions.
Article
Oncology
H. B. Strazzi-Sahyon, L. T. A. Cintra, J. M. Nakao, A. S. Takamiya, I. O. A. Queiroz, P. H. Dos Santos, S. H. P. Oliveira, G. Sivieri-Araujo
Summary: This in vitro study evaluated the cytotoxicity potential of photodynamic therapy (PDT) using curcumin as a photosensitizer (PS) on fibroblasts. The results showed that curcumin PS at a concentration of 1000 mg/L was cytotoxic on L-929 fibroblast cells, while curcumin PS at a concentration of 500 mg/L had no influence on cell viability under in vitro conditions.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Maria Clara Bertolini Botelho, Luciano Tavares Angelo Cintra, Cristiane Cantiga da Silva, Giseli Mitsuy Kayahara, Rosani Belzunces Pereira, Mylena Fernanda Oliveira Santos, Glauco Issamu Miyahara, Eder Ricardo Biasoli, Sandra Helena Penha Oliveira, Daniel Galera Bernabe
Summary: This study evaluated the influence of early life stress on the severity of apical periodontitis in Wistar rats. The results showed that early life stress exacerbates the inflammatory process and increases periapical bone resorption.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Virology
Anna Carolina S. Dantas, Hellen B. M. Oliveira, Camila P. Gomes, Daniele L. Alves, Priscilla D. B. Infante, Rosimara de J. A. Caitite, Hegger M. Fritsch, Marina S. Cucco, Lucas S. C. Silva, Caline N. T. Oliveira, Rafaela de S. Bittencourt, Aline T. Amorim, Ana Luisa P. Nascimento, Francely A. G. C. Marinho, Danielle S. de Medeiros, Marcio G. G. de Oliveira, Sostenes Mistro, Fabricio F. de Melo, Taiana T. S. Pereira, Ana M. S. Guimaraes, Jorge Timenetsky, Pablo Maciel B. Moreira, Sandra Helena P. de Oliveira, Luiz C. J. Alcantara, Marta Giovanetti, Luciane A. Santos, Vagner Fonseca, Fernanda K. Barreto, Guilherme B. Campos, Lucas M. Marques
Summary: This study aimed to identify risk factors for mortality from SARS-CoV-2 infection, evaluate gene expression patterns of immune response pathways in COVID-19 patients, and identify circulating SARS-CoV-2 variants in a medium-sized city in Northeast Brazil. The study found that pre-existing comorbidity, male gender, cardiovascular disease, diabetes, chronic obstructive pulmonary disease, and PCR cycle threshold values under 22 were identified as risk factors for mortality. Furthermore, the study demonstrated that the severity of infection was associated with increased activation of inflammatory pathways, and multiple lineages of the virus were circulating.
Article
Dentistry, Oral Surgery & Medicine
Rodrigo Martins dos Santos, Bianca Elvira Belardi, Thais Veronica Saori Tsosura, Fernando Yamamoto Chiba, Maria Sara de Lima Coutinho Mattera, Nathalia Evelyn Silva Machado, Cristiane Cantiga-Silva, Nubia Ramos Carvalho, Lara Teschi Bravo, Ana Carla Thalez Ywabuchi Nobumoto, Sandra Helena Penha Oliveira, Luciano Tavares Angelo Cintra, Doris Hissako Matsushita
Summary: This study evaluated the effects of melatonin (MEL) on the expression of TLR4, MyD88, TRIF, IRF-3, NF-kappa B, IL-1 beta and LPS, as well as the lipid profile in rats with apical periodontitis (AP) fed on a high-fat diet (HFD). MEL treatment reduced IRF-3 protein expression in the gastrocnemius muscle (GM) and IL-1 beta plasma concentration in the APMEL and HFDMEL groups. LPS plasma concentration decreased only in the HFDMEL group. Additionally, LDL decreased and HDL increased in the HFDMEL and HFDAPMEL groups. Treatment with MEL exhibited anti-inflammatory and anti-hyperlipidemic effects.
Article
Biochemical Research Methods
Vanessa Soares Lara, Rafaela Alves da Silva, Tatiane Ponteado Ferrari, Carlos Ferreira dos Santos, Sandra Helena Penha de Oliveira
Summary: This study evaluated the antimicrobial action of losartan against C. albicans biofilms. The results showed that losartan inhibited the growth of C. albicans biofilms and had no significant toxicity on human cells. This indicates that losartan can be repurposed to interfere with the metabolism and development of Candida biofilms.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Danila de Oliveira, Fernando I. Souza, Mariana T. Caixeta, Cristiane Duque, Sandra H. P. Oliveira, Eduardo P. Rocha
Summary: This study evaluated the impact of ultrathin ceramic laminate veneers placed subgingivally without a finish line on the periodontium. Results showed that the restored teeth had similar periodontal behavior compared to before restoration, indicating that ultrathin ceramic laminate veneers do not contribute to plaque accumulation or changes in oral microbiota.
INTERNATIONAL JOURNAL OF PROSTHODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Pedro Henrique Souza Calefi, India Olinta de Azevedo Queiroz, Murilo Priori Alcalde, Sandra Helena Penha de Oliveira, Rodrigo Ricci Vivan, Paulo Henrique Weckwerth, Augusto Shoji Kato, Marco Antonio Hungaro Duarte
Summary: The study showed that NAC and AMB pastes had higher solubility and cytotoxicity compared to CH paste, and had acidic pH levels. Among them, AMB paste displayed higher antimicrobial action against Enterococcus faecalis biofilm.
EUROPEAN ENDODONTIC JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Fernando Yamamoto Chiba, Thais Veronica Saori Tsosura, Maria Sara de Lima Coutinho Mattera, Renato Felipe Pereira, Rodrigo Martins dos Santos, Renan Akira Fujii de Oliveira, Clea Adas Saliba Garbin, Bianca Elvira Belardi, Sandra Helena Penha de Oliveira, Doris Hissako Matsushita
Summary: This study showed that chronic NaF intake in rats can lead to alterations in the final step of insulin signaling, increase activation of inflammatory signaling pathways, and affect the expression and phosphorylation levels of GLUT4 and Akt in the gastrocnemius muscle.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.