期刊
LEUKEMIA RESEARCH
卷 38, 期 1, 页码 65-70出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.10.016
关键词
VLA-4; CXCR4; Acute lymphoblastic leukemia; Adult; Survival; Prognostic marker
资金
- Asan Institute for Life Sciences [2010-179]
Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p =0.01) and overall survival (p = 0.04) and patients with low VLA-4 expression had shorter disease-free survival (p = 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis. (C) 2013 Elsevier Ltd. All rights reserved.
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