期刊
LEUKEMIA RESEARCH
卷 38, 期 2, 页码 155-160出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.09.008
关键词
Myeloproliferative neoplasm; Unmet clinical need; polycythemia vera; Essential thrombocyt hernia; Myelofibrosis
资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC Milano)
- Special Program Molecular Clinical Oncology 5 x 1000
This article presents the results of group discussion among experts from SIE, SIES and GITMO societies aimed at highlighting unmet challenges in the management of Ph-neg myeloproliferative neoplasms (MPNs). The issues analyzed were: diagnosis of prefibrotic myelofibrosis; diagnosis of Ph-neg MPNs in the setting of splanchnic vein thrombosis (SVT); management of low-risk PV and low-risk ET patients with JAK2V617F mutation; molecular biomarkers in the prognostic evaluation of myelofibrosis (MF); ruxolitinib therapy in low-risk MF; therapy in patients with SVT-associated Ph-neg MPN; indications of splenectomy in MF. For each of these issues, proposals for advancement in clinical research were addressed. (C) 2013 Elsevier Ltd. All rights reserved.
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