期刊
LEUKEMIA RESEARCH
卷 37, 期 10, 页码 1322-1328出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.06.026
关键词
Multiple myeloma; Dexamethasone resistance; Dexamethasone withdrawal; Interleukin-6; AG490; JAK2/STAT3 signaling pathway
资金
- NIH from the IDeA Networks of Biomedical Research Excellence (INBRE) program of the National Center for Research Resources [P20 RR016454, P20 GM103408]
We previously reported the establishment and characteristics of a DXM-resistant cell line (7TD1-DXM) generated from the IL6-dependent mouse B cell hybridoma, 7TD1 cell line. After withdrawing DXM from 7TD1-DXM cells over 90 days, DXM significantly inhibited the cell growth and induced apoptosis in the cells (7TD1-WD) compared with 7TD1-DXM cells. Additionally, IL-6 reversed while IL-6 antibody and AG490 enhanced the effects of growth inhibition and apoptosis induced by DXM in 7TD1-WD cells. Our study demonstrates that 7TD1-DXM cells become resensitized to DXM after DXM withdrawal, and IL-6 and JAK2/STAT3 pathways may regulate the phenomenon. (C) 2013 Elsevier Ltd. All rights reserved.
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