期刊
LEUKEMIA RESEARCH
卷 37, 期 12, 页码 1750-1756出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.10.010
关键词
Oxidative stress; Reactive oxygen species; Hypoxia-inducible factor; ARNT; Chemoresistance
资金
- Canadian Institutes of Health Research
We observed AML cell lines vary in their sensitivity to induction of apoptosis by troglitazone (TG), which induces apoptosis through the generation of intracellular reactive oxygen species (ROS). TG-resistant cell lines had increased abundance of ARNT transcripts and protein. Expression of ARNT in TG-sensitive cells made these cells resistant to both TG and daunorubicin. ARNT-expressing cells had increased expression of SOD2 and Nrf2 transcripts and elevated intracellular GSH concentration. Our results indicate that ARNT expression in AML cells augments antioxidant response and confers resistance to ROS inducers. This suggests ARNT may modulate ROS signaling and drug response in AML. (C) 2013 Elsevier Ltd. All rights reserved.
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