期刊
LEUKEMIA RESEARCH
卷 36, 期 6, 页码 791-798出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2012.02.017
关键词
Adriamycin; Cell cycle; Multiparametric analysis; Polyploid cells; Reactive oxygen species; Apoptosis
资金
- French Ligue Nationale Contre le Cancer (Comites des Pyrenees-Orientales et du Gard)
We investigate the relative importance of the different mechanisms of Adriamycin, an anthracycline, and their interrelations, in particular the link between cell cycle arrest, cell death, and generation of reactive oxygen species (ROS) that is suspected to be the origin of cardiotoxic side-effects. We introduced a lifetime fluorescence based technology and used videomicrofluorometry, two efficient analytical methods. We show that depending on the doses and time after incubation, ADR will not reach the same compartments (nucleus, mitochondria, cytosol) in the cells, having consequences on the production of ROS, growth arrest pathways and cell death pathways. (C) 2012 Elsevier Ltd. All rights reserved.
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