期刊
LEUKEMIA RESEARCH
卷 35, 期 7, 页码 874-878出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2010.11.010
关键词
Regulatory T-cells; Thalidomide; Myeloma; FoxP3
资金
- Department of Biotechnology, Ministry of Science and Technology, Govt. of India
Increases in regulatory T-cells have been demonstrated in hematological malignancies but conflicting results have been reported in multiple myeloma (MM). In this study, we report a decrease in frequency of regulatory T-cells as well as reduced expression of FoxP3 in untreated MM patients which increased significantly after treatment. Regulatory T-cells of MM patients exhibited immunosuppressive activity in an in vitro assay. Reduced regulatory T-cells in untreated MM patients which increased after treatment with thalidomide, suggests the analysis of treated and untreated patients as a single cohort as cause of conflicting results in earlier studies on regulatory T-cells in MM. (C) 2010 Elsevier Ltd. All rights reserved.
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