☆ 4.3 Article

Aberrant microRNA expression pattern in myelodysplastic bone marrow cells

LEUKEMIA RESEARCH (2010)

期刊

LEUKEMIA RESEARCH

卷 34, 期 9, 页码 1169-1174

出版社

PERGAMON-ELSEVIER SCIENCE LTD

DOI: 10.1016/j.leukres.2010.04.012

关键词

microRNA; Expression profile; Myelodysplastic syndrome; MDS; del(5q); -7; +8; Bone marrow cells

类别

Oncology Hematology

资金

Deutsche Krebshilfe, Dr. Mildred Scheel Stiftung, Bonn, Germany
Deutsche Forschungsgemeinschaft - DFG, Bonn, Germany
Hochschul-interne Leistungsforderung - HiLF, Medizinische Hochschule Hannover, Hannover, Germany

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Protocol

Reagent

摘要

The microRNA/miR system might contribute to deregulation of cell homeostasis/disease phenotype. This is the first approach to generate an expression profile of 365 microRNAs in myelodysplastic syndromes (MDS) with normal karyotype (n = 12) and distinct cytogenetic aberrations (n = 12). In MDS-del(5q), a series of microRNAs not in the 5q-region was increased. MicroRNAs encoded on chromosomes 5, 7 and 8 were not differentially expressed in MDS with del(5q), -7 or +8. Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS. These findings provide evidence that MDS-haematopoiesis is distinct in its microRNA-expression pattern from non-neoplastic cells. (C) 2010 Elsevier Ltd. All rights reserved.

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