Article
Chemistry, Medicinal
Hana Votavova, Zuzana Urbanova, David Kundrat, Michaela Dostalova Merkerova, Martin Vostry, Monika Hruba, Jaroslav Cermak, Monika Belickova
Summary: DFX improves hematopoiesis in anemic myelodysplastic syndrome patients by modulating immune response, suppressing negative regulators of blood cell differentiation, and upregulating heme metabolism.
Article
Oncology
Laurent Pascal
Summary: Iron overload is harmful to elderly patients with low-risk myelodysplastic syndromes (MDS), especially those with cardiovascular disease. A randomized study has shown improved event-free survival with Iron Chelation Therapy (ICT) in these patients. Further research is needed to better understand the benefits of ICT.
BULLETIN DU CANCER
(2023)
Review
Immunology
Sarah Weber, Anastasia Parmon, Nina Kurrle, Frank Schnuetgen, Hubert Serve
Summary: MDS and AML patients often experience systemic iron overload issues, iron is closely associated with the pathogenesis and potential treatment strategies of the diseases, imbalances in iron homeostasis may lead to various cell death.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Md Jubayer Hossain, Md Wahidul Islam, Ummi Rukaiya Munni, Rubaiya Gulshan, Sumaiya Akter Mukta, Md Sharif Miah, Sabia Sultana, Mousumi Karmakar, Jannatul Ferdous, Mohammad Ariful Islam
Summary: This study aimed to determine the health-related quality of life (HRQoL) and its determinants among thalassemia patients in Bangladesh. A cross-sectional survey was conducted on 356 randomly selected patients. Findings showed that male patients had higher scores in bodily pains and physical health summaries compared to female patients. Lower income, frequent blood transfusion, disease severity, comorbidities, and medical expenses were significantly associated with lower SF-36 scores.
SCIENTIFIC REPORTS
(2023)
Article
Hematology
A. Kasprzak, K. Nachtkamp, M. Kondakci, T. Schroeder, G. Kobbe, A. Kuendgen, J. Kaivers, C. Rautenberg, R. Haas, N. Gattermann, N. Bonadies, U. Germing
Summary: The study indicates that adherence to ELN guidelines may not necessarily improve survival rates for patients with myelodysplastic syndromes (MDS), except for allogeneic stem cell transplantation (alloSCT) and iron chelation therapy (ICT). It is recommended to pursue alloSCT in all suitable candidates.
ANNALS OF HEMATOLOGY
(2021)
Review
Medicine, Research & Experimental
Michael Morales, Xiang Xue
Summary: Iron is crucial for cellular functions and human health, but excess iron can lead to oxidative DNA damage and cancer. Cancer cells are more dependent on iron than normal cells, making targeting iron metabolism in cancer cells an emerging and powerful therapeutic strategy.
Article
Pediatrics
Rafaa Mohamed, Amir Hamzah Abdul Rahman, Farin Masra, Zarina Abdul Latiff
Summary: This study aimed to determine the association between mean serum ferritin level and self-reported level of adherence to iron chelation therapy in transfusion dependent thalassemia (TDT) adolescents in Hospital Tengku Ampuan Afzan (HTAA), Kuantan and Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Cheras; and to determine the association between socio-demographic factors and patients' knowledge on thalassemia and iron chelation therapy with the level of adherence.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Mathias Schneeweiss-Gleixner, Georg Greiner, Susanne Herndlhofer, Julia Schellnegger, Maria-Theresa Krauth, Karoline Gleixner, Friedrich Wimazal, Corinna Steinhauser, Michael Kundi, Renate Thalhammer, Ilse Schwarzinger, Gregor Hoermann, Harald Esterbauer, Manuela Fodinger, Peter Valent, Wolfgang R. Sperr
Summary: Although iron overload is a clinical challenge, little is known about the clinical impact of HFE-variants in myelodysplastic syndromes. The study found that HFE-variants H63D and C282Y are frequently detected in Austrian MDS patients, who have higher ferritin levels at diagnosis, accumulate iron slightly faster, and have a better progression-free survival than non-mutated patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Jessica M. Stempel, Nikolai A. Podoltsev, Talib Dosani
Summary: Myelodysplastic syndromes (MDS) are a group of bone marrow disorders characterized by ineffective hematopoiesis, progressive cytopenias, and the potential to progress to acute myeloid leukemia (AML). The most common causes of morbidity and mortality in MDS patients are complications related to MDS itself rather than progression to AML. Supportive care measures are essential, especially in lower-risk MDS patients with a better prognosis, who require long-term monitoring of disease and treatment-related complications. This review discusses the frequent complications and supportive care interventions in MDS patients, including transfusion support, iron overload management, antimicrobial prophylaxis, considerations in the era of COVID-19, routine immunizations, and palliative care.
Article
Pharmacology & Pharmacy
Ruoxi Zhang, Bing Han
Summary: This study aimed to evaluate the efficacy and dose-effect relationship of DFX in patients with low-risk MDS and AA. The results showed that significant improvements in SF, haematological parameters, organ function, and overall survival can be achieved by reaching a certain accumulated dose of DFX. Low-risk MDS patients require a higher dose compared to those with AA.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Jessica van Hattem, Philip Maes, Tonya Marianne Esterhuizen, Ann Devos, Martin Ruppert, Jaques van Heerden
Summary: Limited data on erythrocytapheresis in children, adolescents, and young adults have been published. This study aimed to evaluate the effectiveness of erythrocytapheresis, either alone or in combination with iron chelation therapy, in managing iron overload in patients with hemoglobinopathies. The results showed that erythrocytapheresis significantly reduced serum ferritin levels and had a better effect compared to iron chelation therapy alone. This study demonstrates that erythrocytapheresis is a promising therapy for treating transfusion-related iron overload.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Felicitas Schulz, Ulrich Hauch, Sandra Ketzler-Henkel, Eyck von der Heyde, Michael Koenigsmann, Michael Lauseker, Nora Schulte, Ulrich Germing
Summary: Myelodysplastic syndromes and myeloproliferative neoplasms are hematologic diseases associated with bone marrow failure, and transfusion of red blood cells is necessary but leads to iron overload. Therefore, iron chelation therapy plays a crucial role in anemic patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Toni Valkovic, Marija Stanic Damic
Summary: Iron plays an important role in the survival and reproduction of fungal pathogens, and there is evidence linking invasive fungal infections to iron or iron overload. Understanding the association between iron and iron overload with susceptibility to invasive fungal infections is crucial, especially for patients with hematological malignancies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Verena Petzer, Igor Theurl, Gunter Weiss, Dominik Wolf
Summary: Systemic iron overload in patients with MDS is multifactorial, mainly due to ineffective erythropoiesis and chronic red blood cell transfusion. Iron homeostasis varies among different MDS subtypes and its role in MDS is increasingly recognized. Genetic alterations, such as mutations in TET2, can lead to disturbances in iron homeostasis and hematopoiesis, highlighting the need for comprehensive understanding and development of future therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Reem Aldwaik, Tamara Abu Mohor, Israa Idyabi, Salam Warasna, Shatha Abdeen, Bashar Karmi, Rania Abu Seir
Summary: Management of beta-thalassemia in the West Bank presents challenges due to the lack of available therapies, leading to recurrent transfusions. Characteristics of patients include anemia, iron overload, and abnormal liver function tests. Iron chelation medication choice is associated with serum ferritin levels, highlighting the need for personalized assessment and follow-up protocols.
FRONTIERS IN MEDICINE
(2021)
Article
Hematology
Maria Diez-Campelo, Jose I. Lorenzo, Raphael Itzykson, Silvia M. Rojas, Celine Berthon, Elisa Luno, Odile Beyne-Rauzy, Jaime Perez-Oteyza, Norbert Vey, Joan Bargay, Sophie Park, Teresa Cedena, Dominique Bordessoule, Juan A. Munoz, Emmanuel Gyan, Esperanza Such, Sorin Visanica, Felix Lopez-Cadenas, Stephane de Botton, Jesus M. Hernandez-Rivas, Shanti Ame, Aspasia Stamatoullas, Jacques Delaunay, Celia Salanoubat, Francoise Isnard, Romain Guieze, Joan Perez Guallar, Llorenc Badiella, Guillermo Sanz, Consuelo Canizo, Pierre Fenaux
BRITISH JOURNAL OF HAEMATOLOGY
(2018)
Article
Hematology
Anais Essilini, Thibault Comont, Johanne Germain, Natacha Brun, Claire Dingremont, Brice Castel, Sophie Arista, Serge Madaule, Laurent Sailler, Maryse Lapeyre-Mestre, Odile Beyne-Rauzy, Bertrand Godeau, Daniel Adoue, Guillaume Moulis
EUROPEAN JOURNAL OF HAEMATOLOGY
(2018)
Article
Hematology
Christian Rose, Caroline Lenoir, Emmanuel Gyan, Maya Hacini, Shanti Ame, Bernadette Corront, Odile Beyne-Rauzy, Didier Adiko, Elena Loppinet, Nadia Ali-Ammar, Kamel Laribi, Eric Wattel, Francois Dreyfus, Claire S. Roue, Stephane Cheze
EUROPEAN JOURNAL OF HAEMATOLOGY
(2018)
Article
Hematology
M. -L. Piel-Julian, M. Mahevas, J. Germain, L. Languille, T. Comont, M. Lapeyre-Mestre, B. Payrastre, O. Beyne-Rauzy, M. Michel, B. Godeau, D. Adoue, G. Moulis
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2018)
Article
Oncology
Louise de Swart, Alex Smith, Detlef Haase, Pierre Fenaux, Argiris Symeonidis, Jaroslav Cermak, Guillermo Sanz, Reinhard Stauder, Moshe Mittelman, Eva Hellstrom-Lindberg, Luca Malcovati, Saskia Langemeijer, Mette Skov-Holm, Krzysztof Madry, Ulrich Germing, Antonio Medina Almeida, Aurelia Tatic, Aleksandar Savic, Njetocka Gredelj Simec, Corine van Marrewijk, Agnes Guerci-Bresler, Laurence Sanhes, Elisa Luno, Dominic Culligan, Odile Beyne-Rauzy, Sonja Burgstaller, Nicole Blijlevens, David Bowen, Theo de Witte
Article
Hematology
Rami Komrokji, Guillermo Garcia-Manero, Lionel Ades, Thomas Prebet, David P. Steensma, Joseph G. Jurcic, Mikkael A. Sekeres, Jesus Berdeja, Michael R. Savona, Odile Beyne-Rauzy, Aspasia Stamatoullas, Amy E. DeZern, Jacques Delaunay, Gautam Borthakur, Robert Rifkin, Thomas E. Boyd, Abderrhamane Laadem, Bond Vo, Jennie Zhang, Marie Puccio-Pick, Kenneth M. Attie, Pierre Fenaux, Alan F. List
LANCET HAEMATOLOGY
(2018)
Article
Hematology
Marie Sebert, Aline Renneville, Cecile Bally, Pierre Peterlin, Odile Beyne-Rauzy, Laurence Legros, Marie-Pierre Gourin, Laurence Sanhes, Eric Wattel, Emmanuel Gyan, Sophie Park, Aspasia Stamatoullas, Anne Banos, Kamel Laribi, Simone Jueliger, Luke Bevan, Fatiha Chermat, Rosa Sapena, Olivier Nibourel, Cendrine Chaffaut, Sylvie Chevret, Claude Preudhomme, Lionel Ades, Pierre Fenaux
Review
Medicine, General & Internal
T. Comont, K. Delavigne, P. Cougoul, S. Bertoli, E. Delabesse, P. Fenaux, O. Beyne-Rauzy
REVUE DE MEDECINE INTERNE
(2019)
Article
Hematology
Louise de Swart, Simon Crouch, Marlijn Hoeks, Alex Smith, Saskia Langemeijer, Pierre Fenaux, Argiris Symeonidis, Jaroslav Cermak, Eva Hellstrom-Lindberg, Reinhard Stauder, Guillermo Sanz, Moshe Mittelman, Mette Skov Holm, Luca Malcovati, Krzysztof Madry, Ulrich Germing, Aurelia Tatic, Aleksandar Savic, Antonio Medina Almeida, Njetocka Gredelj-Simec, Agnes Guerci-Bresler, Odile Beyne-Rauzy, Dominic Culligan, Ioannis Kotsianidis, Raphael Itzykson, Corine van Marrewijk, Nicole Blijlevens, David Bowen, Theo de Witte
Review
Medicine, General & Internal
T. Comont, J. Belliere, V. Sibaud, L. Alric, N. Meyer, J. Mazieres, P. Caron, B. Acket, J. -M. Michot, O. Beyne-Rauzy, O. Lambotte
REVUE DE MEDECINE INTERNE
(2020)
Meeting Abstract
Hematology
Thomas Cluzeau, Marie Sebert, Ramy Rahme, Stefania Cuzzubbo, Anouk Walter-petrich, Jacqueline Lehmann Che, Pierre Peterlin, Blandine Beve, Habiba Attalah, Fatiha Chermat, Elsa Miekoutima, Odile Beyne-Rauzy, Christian Recher, Aspasia Stamatoullas, Lise Willems, Emmanuel Raffoux, Celine Berthon, Bruno Quesnel, Antoine Carpentier, David A. Sallman, Sylvie Chevret, Lionel Ades, Pierre Fenaux
Article
Medicine, General & Internal
Pierre Fenaux, Uwe Platzbecker, Ghulam J. Mufti, Guillermo Garcia-Manero, Rena Buckstein, Valeria Santini, Maria Diez-Campelo, Carlo Finelli, Mario Cazzola, Osman Ilhan, Mikkael A. Sekeres, Jose F. Falantes, Beatriz Arrizabalaga, Flavia Salvi, Valentina Giai, Paresh Vyas, David Bowen, Dominik Selleslag, Amy E. DeZern, Joseph G. Jurcic, Ulrich Germing, Katharina S. Goetze, Bruno Quesnel, Odile Beyne-Rauzy, Thomas Cluzeau, Maria-Teresa Voso, Dominiek Mazure, Edo Vellenga, Peter L. Greenberg, Eva Hellstrom-Lindberg, Amer M. Zeidan, Lionel Ades, Amit Verma, Michael R. Savona, Abderrahmane Laadem, Aziz Benzohra, Jennie Zhang, Anita Rampersad, Diana R. Dunshee, Peter G. Linde, Matthew L. Sherman, Rami S. Komrokji, Alan F. List
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Meeting Abstract
Hematology
Pierre Fenaux, Uwe Platzbecker, Ghulam J. Mufti, Guillermo Garcia-Manero, Rena Buckstein, Valeria Santini, Maria Diez-Campelo, Carlo Finelli, Mario Cazzola, Osman Ilhan, Mikkael A. Sekeres, Jose F. Falantes, Beatriz Arrizabalaga, Flavia Salvi, Valentina Giai, Paresh Vyas, David Bowen, Dominik Selleslag, Amy E. DeZern, Joseph G. Jurcic, Ulrich Germing, Katharina S. Goetze, Bruno Quesnel, Odile Beyne-Rauzy, Thomas Cluzeau, Maria Teresa Voso, Dominiek Mazure, Edo Vellenga, Peter L. Greenberg, Eva Hellstrom-Lindberg, Amer M. Zeidan, Abderrahmane Laadem, Aziz Benzohra, Jennie Zhang, Anita Rampersad, Peter G. Linde, Matthew L. Sherman, Rami S. Komrokji, Alan F. List
Meeting Abstract
Hematology
Lionel Ades, Agnes Guerci, Kamel Laribi, Pierre Peterlin, Norbert Vey, Sylvain Thepot, Stefan Wickenhauser, Hacene Zerazhi, Aspasia Stamatoullas, Eric Wattel, Christian Recher, Andrea Toma, Krimo Bouabdallah, Thorsten Braun, Odile Beyne-Rauzy, Berengere Gruson, Stephane Cheze, Sophie Park, Thomas Cluzeau, Stanislas Nimubona, Dominique Bordessoule, Riad Benramdane, Bruno Quesnel, Shanti Ame, Stephane De Botton, Fatiha Chermat, Julie Lejeune, Sylvie Chevretand, Pierre Fenaux
Letter
Obstetrics & Gynecology
Thibault Comont, Guillaume Moulis, Karen Delavigne, Pierre Cougoul, Olivier Parant, Beatrice Guyard-Boileau, Helene Derumeaux, Daniel Adoue, Odile Beyne-Rauzy
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2018)