期刊
LEUKEMIA RESEARCH
卷 34, 期 7, 页码 871-876出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2010.01.005
关键词
Bone marrow fibrosis; Digital imaging; Myeloproliferative neoplasms; Osteosclerosis
资金
- MPD research consortium
- NCI [1P01CA108671-O1A2]
Evaluation of bone marrow fibrosis and osteosclerosis in myeloproliferative neoplasms (MPN) is subject to interobserver inconsistency. Performance data for currently utilized fibrosis grading systems are lacking, and classification scales for osteosclerosis do not exist. Digital imaging can serve as a quantification method for fibrosis and osteosclerosis. We used digital imaging techniques for trabecular area assessment and reticulin fiber quantification. Patients with all Philadelphia negative MPN subtypes had higher trabecular volume than controls ( p <= 0.0015). Results suggest that the degree of osteosclerosis helps differentiate primary myelofibrosis from other MPN. Numerical quantification of fibrosis highly correlated with subjective scores, and interobserver correlation was satisfactory. Digital imaging provides accurate quantification for osteosclerosis and fibrosis. (C) 2010 Elsevier Ltd. All rights reserved.
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