Levels of beta 2 microglobulin have a prognostic relevance for patients with myelodysplastic syndrome with regard to survival and the risk of transformation into acute myelogenous leukemia

We evaluated the relevance of beta 2 microglobulin (B2M) plasma concentration in 109 patients with myelodysplastic syndrome (MDS) front the Duesseldorf registry. Sixty-five patients with B2M level >= 2 mg/dl showed a significantly lower overall survival time with a median of 23 in comparison to 61 months for 44 patients with B2M below 2 mg/dl, The risk of AML evolution was higher in patients with B2M >= 2 mg/dl. Using multivariate analysis We found the B2M level at the time of diagnosis to be an independent prognostic parameter for survival and for the risk of developing AML in high-risk MDS patients. (C) 2008 Elsevier Ltd. All rights reserved.