期刊
LEUKEMIA RESEARCH
卷 32, 期 11, 页码 1763-1769出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2008.04.001
关键词
multiple myeloma; MMPs; TIMPs; bone marrow stroma
We have investigated the production of metalloproteinases (MMP-1, MMP-2, MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in bone marrow stromal cells (BMSCs) of patients with multiple myeloma (MM) and a healthy control. The new findings of this paper is that BMSCs of the MM patients exhibited intrinsic MMP-1, MMP-2 and TIMP-2 overproduction. Production of MMP-1, TIMP-2 and activation of MMP-2 was additionally enhanced in co-cultures of BMSCs with RPM18226 cells. The ratio between MMP-2 and TIMP-2 was significantly higher in BMCs of the MM patients than in control. BMSCs of both control and the MM patients exhibited the presence of MMP-9 latent form, but in co-cultures RPM18226 cells were the main producers of this metalloproteinase. (C) 2008 Elsevier Ltd. All rights reserved.
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