期刊
LEUKEMIA RESEARCH
卷 32, 期 9, 页码 1458-1461出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2007.11.030
关键词
monoclonal B-cell lymphocytosis; chronic lymphocytic leukemia; diangosis; prognosis
资金
- NCI NIH HHS [CA 113408, K23 CA113408, K23 CA113408-01A1] Funding Source: Medline
To eliminate overlap with monoclonal B-cell lymphocytosis (MBL), some have proposed basing the diagnosis of chronic lymphocytic leukemia (CLL) on B lymphocyte count rather than absolute lymphocyte count (ALC). Such criteria should be based, in part, on patient outcomes. We evaluated the clinical implications of the proposed re-classification in 112 consecutive, newly diagnosed, Rai stage 0 patients. The new criteria would have changed the diagnosis from CLL to MBL in 47/112 (42%) patients. There was no difference in time to treatment (TTT) between those classified as MBL and CLL under the new criteria. In contrast, CD38 predicted TTT (p = 0.02) regardless of the proposed new classification. Molecular characteristics of the leukemic clone are a better predictor of progression than an arbitrary ALC or B lymphocyte count threshold. (C) 2007 Elsevier Ltd. All rights reserved.
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