Bezafibrate and medroxyprogesterone acetate target resting and CD40L-stimulated primary marginal zone lymphoma and show promise in indolent B-cell non-Hodgkin lymphomas

Novel targeted therapies for mantle cell lymphoma

(2015) Lapo Alinari et al.   Oncotarget

Bezafibrate and medroxyprogesterone acetate in resistant and relapsed endemic Burkitt lymphoma in Malawi; an open-label, single-arm, phase 2 study (ISRCTN34303497)

(2013) Elizabeth Molyneux et al.   BRITISH JOURNAL OF HAEMATOLOGY

New developments in the management of diffuse large B-cell lymphoma

(2012) Habermann   Hematology

Follicular lymphoma tumor-infiltrating T-helper (TH) cells have the same polyfunctional potential as normal nodal TH cells despite skewed differentiation

(2011) S. P. Hilchey et al.   BLOOD

PI3K  inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma

(2011) S. A. Meadows et al.   BLOOD

The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo

(2011) S. Ponader et al.   BLOOD

The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia

(2011) J. Hoellenriegel et al.   BLOOD

CAL-101: a phosphatidylinositol-3-kinase p110-delta inhibitor for the treatment of lymphoid malignancies

(2011) Jorge J Castillo et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Novel Therapeutics for Aggressive Non-Hodgkin's Lymphoma

(2011) Daruka Mahadevan et al.   JOURNAL OF CLINICAL ONCOLOGY

Monocytes and T cells cooperate to favor normal and follicular lymphoma B-cell growth: role of IL-15 and CD40L signaling

(2011) G Epron et al.   LEUKEMIA

Treatment of chronic lymphocytic leukemia requires targeting of the protective lymph node environment with novel therapeutic approaches

(2011) Rachel E. Hayden et al.   LEUKEMIA & LYMPHOMA

CAL-101, a p110  selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

(2010) B. J. Lannutti et al.   BLOOD

Phosphatidylinositol 3-kinase-  inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

(2010) S. E. M. Herman et al.   BLOOD

Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML)

(2010) Jim A. Murray et al.   BRITISH JOURNAL OF HAEMATOLOGY

Therapeutic advances in leukemia and myelodysplastic syndrome over the past 40 years

(2010) Hagop Kantarjian et al.   CANCER

Management of Mantle Cell Lymphoma: Key Challenges and Next Steps

(2010) Michael E. Williams et al.   Clinical Lymphoma Myeloma & Leukemia

Lycorine sensitizes CD40 ligand-protected chronic lymphocytic leukemia cells to bezafibrate- and medroxyprogesterone acetate-induced apoptosis but dasatanib does not overcome reported CD40-mediated drug resistance

(2010) R. E. Hayden et al.   HAEMATOLOGICA

B-cell receptor signaling and CD40 ligand-independent T cell help cooperate in Helicobacter-induced MALT lymphomagenesis

(2010) V J Craig et al.   LEUKEMIA

Targeting the microenvironment

(2010) John Gribben et al.   LEUKEMIA & LYMPHOMA

Combined Bezafibrate and Medroxyprogesterone Acetate: Potential Novel Therapy for Acute Myeloid Leukaemia

(2009) Farhat L. Khanim et al.   PLoS One

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

(2008) M. Vogler et al.   BLOOD

Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis

(2008) Cornelia Hömig-Hölzel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dΔ12,14,PGJ2

(2008) R E Hayden et al.   LEUKEMIA