☆ 4.3 Letter

Alternative technique for intrafemoral injection and bone marrow sampling in mouse transplant models

LEUKEMIA & LYMPHOMA (2011)

期刊

LEUKEMIA & LYMPHOMA

卷 52, 期 9, 页码 1806-1808

出版社

INFORMA HEALTHCARE

DOI: 10.3109/10428194.2011.580023

关键词

-

类别

Oncology Hematology

向作者/读者索取更多资源

Protocol

Reagent

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Editorial Material Hematology

Towards a standard of care in transplant for WAS

Susan E. Prockop

Summary: In this article, the authors demonstrate that a standardized treatment approach combined with novel composite end points can establish a standard of care for boys with this rare nonmalignant disorder even in the absence of prospective trials.

BLOOD (2022)

添加到收藏夹

Review Immunology

The role of inflammation in hematopoiesis and bone marrow failure: What can we learn from mouse models?

Jun Wang, Miriam Erlacher, Juncal Fernandez-Orth

Summary: Under inflammatory conditions, steady-state hematopoiesis switches to emergency myelopoiesis, leading to different forms of cell death and other changes in the hematopoietic system, ultimately causing loss of hematopoiesis function. In individuals with inherited bone marrow failure syndromes or immune-mediated aplastic anemia, chronic inflammatory signals may aggravate disease progression.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Oncology

Direct bone marrow injection of human bone marrow-derived stromal cells into mouse femurs results in greater prostate cancer PC-3 cell proliferation, but not specifically proliferation within the injected femurs

Bianca Nowlan, Elizabeth D. Williams, Michael Robert Doran

Summary: The study evaluated the impact of partially humanizing mouse bone marrow with human bone marrow-derived stromal cells on human prostate cancer cell behavior. Results showed that PC-3-DsRed cells preferentially populated bones in mice that had received human BMSC, and there were more bone lesions in these mice.

BMC CANCER (2022)

添加到收藏夹

Article Cell & Tissue Engineering

Intra-iliac bone marrow injection as a novel alternative to intra-tibial inoculation in rat model

Marwa S. Khattab, Huda O. AbuBakr, Kassem G. El Iraqi, Naglaa A. AbdElKader, Mervat M. Kamel, Khaled Hamed Salem, Julia Steitz, Mamdouh Afify

Summary: Intra-iliac injections cause less distress on animals compared to intra-tibial injections, and by 3 weeks, the animals regained their normal activity.

STEM CELL RESEARCH & THERAPY (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Is percutaneous injection of bone marrow concentrate, demineralized bone matrix and PRF an alternative to curettage and bone grafting for treating aneurysmal bone cyst?

Luca Cevolani, Laura Campanacci, Andrea Sambri, Enrico Lucarelli, Massimiliano De Paolis, Davide Maria Donati

Summary: A single injection with autologous BMC combined with DBM and PRF showed similar efficacy to curettage and bone grafting for treating ABC, with a lower rate of additional treatment needed. Younger age and cyst location in the long bones of the lower limbs were associated with higher risk of local recurrence.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2021)

添加到收藏夹

Review Chemistry, Analytical

New approaches of slurry sampling as an alternative technique of sample preparing for elemental analysis

Uillian Mozart Ferreira Mata Cerqueira, Marcos Almeida Bezerra, Valfredo Azevedo Lemos, Joselanio Jesus Coutinho, Cleber Galvao Novaes, Sulene Alves Araujo, Lays Pereira do Nascimento

Summary: This article presents a review on the application of slurry sampling for the determination of metals and metalloids using spectroanalytical techniques. The fundamentals, characteristics, advantages, and limitations of this approach are discussed. The critical parameters for optimizing slurry sampling procedures are also discussed. Additionally, innovative approaches and trends related to slurry sampling are highlighted.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2023)

添加到收藏夹

Article Microbiology

Pneumocystis jirovecii Pneumonia Prophylaxis with Intravenous Pentamidine in Adult Allogeneic Hematopoietic Stem Cell Transplant Patients

Shiela McCollam, James S. Lewis, Joseph Bubalo, Amber Diaz

Summary: This study aimed to evaluate the efficacy and safety of 300-mg once-monthly intravenous (IV) pentamidine prophylaxis in 702 adult allogeneic hematopoietic stem cell transplant (HSCT) patients. The results showed that IV pentamidine administration effectively prevented Pneumocystis jirovecii pneumonia (PJP), but breakthrough Nocardia and Toxoplasma infections were observed in a certain percentage of patients.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2022)

添加到收藏夹

Article Orthopedics

Outcomes of iliac crest bone marrow aspirate injection for the treatment of recalcitrant Achilles tendinopathy

Wisutthinee Thueakthong, Cesar de Cesar Netto, Apiporn Garnjanagoonchorn, Jonathan Day, Guy Friedman, Harry Auster, Eric Tan, Lew C. Schon

Summary: Iliac crest bone marrow aspirate (BMA) injections appear to be a safe, effective, and potentially lasting treatment option for patients with intractable Achilles tendinopathy, with statistically significant decrease in NRS pain score post-operatively and no complications at the donor or injection site.

INTERNATIONAL ORTHOPAEDICS (2021)

添加到收藏夹

Article Medicine, General & Internal

Investigation of typhlitis in bone marrow transplant patients in a stem cell transplant unit

Burak Deveci, George Kublashvili, Saim Yilmaz, Baris Ozcan, Halil Fatih Korkmaz, Olcay Gursoy, Tayfur Toptas, Levent Dosemeci, Rabin Saba

Summary: Typhlitis is a type of enterocolitis that develops specifically in immunosuppressive patients with hematological malignancies. This retrospective study aimed to analyze the causes and risk factors for the development of typhlitis in hematopoietic stem cell transplant patients. The study found that male sex, length of hospital stay, febrile neutropenia, antibiotic and antifungal use, duration of neutropenia, diarrhea, and mucositis and additional bacterial infections were significant risk factors for typhlitis. The study highlights the importance of considering these factors in patient follow-up.

MEDICINE (2022)

添加到收藏夹

Article Oncology

Role of β3-Adrenergic Receptor in Bone Marrow Transplant as Therapeutical Support in Cancer

Nicoletta Nastasi, Gennaro Bruno, Claudio Favre, Maura Calvani

Summary: Research on the role of beta 3-adrenergic receptor in bone marrow suggests that modulation of beta 3-AR could potentially regulate hematopoietic stem cell trafficking and hematopoiesis, contributing to the improvement of bone marrow transplants.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Article Hematology

Ischemic-Trained Monocytes Improve Arteriogenesis in a Mouse Model of Hindlimb Ischemia

Gustavo Falero-Diaz, Catarina de A. Barboza, Felipe Pires, Maeva Fanchin, Jingjing Ling, Zachary M. Zigmond, Anthony J. Griswold, Laisel Martinez, Roberto Vazquez-Padron, Omaida C. Velazquez, Roberta M. Lassance-Soares

Summary: This study found that functional reprogramming of monocytes after ischemia training improves blood flow and arteriogenesis after hindlimb ischemia. The changes in metabolism and gene expression may contribute to this beneficial effect.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Preclinical models for investigating how bone marrow adipocytes influence bone and hematopoietic cellularity

Ziru Li, Ormond A. MacDougald

Summary: Laboratory mice are a valuable preclinical model for studying common human diseases related to osteopenia or hematopoietic disorders. However, factors such as species, age, sex, skeletal site, and treatment protocol should all be taken into consideration when choosing the appropriate model for future studies.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

添加到收藏夹

Article Biophysics

Pre-transplant myeloid and immune suppression, upfront plerixafor mobilization and post-transplant cyclophosphamide: novel strategy for haploidentical transplant in sickle cell disease

Gaurav Kharya, Atish Bakane, Shirali Agarwal, Archana Rauthan

Summary: The T-cell-replete haploidentical transplant with PTIS, augmented John Hopkins conditioning and plerixafor-based mobilization is a safe and effective way of treating patients suffering from SCD, with minimal or no risk of graft failure and acceptable GvHD rates.

BONE MARROW TRANSPLANTATION (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Isolation of Mouse Megakaryocyte Progenitors

Quentin Kimmerlin, Manuela Tavian, Christian Gachet, Francois Lanza, Nathalie Brouard

Summary: Bone marrow megakaryocytes ensure the production of blood platelets through a complex process involving different progenitor populations. This protocol details a procedure for isolating and characterizing hematopoietic progenitors from mouse bone marrow, leading to the purification of highly specific megakaryocyte progenitor populations. The technique provides ample cellular material for molecular characterization, in vitro differentiation assays, and modeling interactions with the microenvironment.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Intraperitoneal injection of Desferal® alleviated the age-related bone loss and senescence of bone marrow stromal cells in rats

Lingxian Yi, Yue Ju, Ying He, Xiushan Yin, Ye Xu, Tujun Weng

Summary: Desferal (R) significantly prevented age-related bone loss in aged rats by promoting BMSC growth potential, improving the balance of osteogenic and adipogenic differentiation, rejuvenating senescent BMSCs, and revising the expression of stemness/senescence-associated genes. The study demonstrated a novel role of Desferal (R) in rejuvenating aged BMSCs and preventing age-related bone loss.

STEM CELL RESEARCH & THERAPY (2021)

添加到收藏夹

Article Oncology

Clonal dynamics in pediatric B-cell precursor acute lymphoblastic leukemia with very early relapse

Zeljko Antic, Jiangyan Yu, Beat C. Bornhauser, Stefan H. Lelieveld, Cedric G. van der Ham, Simon van Reijmersdal, Lionel Morgado, Sarah Elitzur, Jean-Pierre Bourquin, Giovanni Cazzaniga, Cornelia Eckert, Mireia Camos, Rosemary Sutton, Helene Cave, Anthony Moorman, Edwin Sonneveld, Ad Geurts van Kessel, Frank N. van Leeuwen, Peter M. Hoogerbrugge, Esme Waanders, Roland P. Kuiper

Summary: Early relapses in BCP-ALL often arise from minor subclones at diagnosis. Understanding the therapeutic pressure driving these events may help develop improved therapies.

PEDIATRIC BLOOD & CANCER (2022)

添加到收藏夹

Article Hematology

Blinatumomab in pediatric relapsed/refractory B-cell acute lymphoblastic leukemia: RIALTO expanded access study final analysis

Franco Locatelli, Gerhard Zugmaier, Noemi Mergen, Peter Bader, Sima Jeha, Paul-Gerhardt Schlegel, Jean-Pierre Bourquin, Rupert Handgretinger, Benoit Brethon, Claudia Roessig, William N. Kormany, Puneeth Viswagnachar, Christiane Chen-Santel

Summary: This study examined the safety and efficacy of blinatumomab in pediatric patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia (R/R B-ALL). The results showed that blinatumomab is a safe and effective treatment option for pediatric R/R B-ALL, inducing complete response (CR) and measurable residual disease (MRD) response, and improving relapse-free survival (RFS) and overall survival (OS).

BLOOD ADVANCES (2022)

添加到收藏夹

Article Hematology

Combining daratumumab with CD47 blockade prolongs survival in preclinical models of pediatric T-ALL

Kristina Mueller, Fotini Vogiatzi, Dorothee Winterberg, Thies Rosner, Lennart Lenk, Lorenz Bastian, Carina L. Gehlert, Marie-Pauline Autenrieb, Monika Bruggemann, Gunnar Cario, Martin Schrappe, Andreas E. Kulozik, Cornelia Eckert, Anke K. Bergmann, Beat Bornhauser, Jean-Pierre Bourquin, Thomas Valerius, Matthias Peipp, Christian Kellner, Denis M. Schewe

Summary: This study suggests that combining CD47 blockade with Dara is a promising therapy for T-ALL, especially for relapsed/refractory disease harboring a dismal prognosis in patients.

BLOOD (2022)

添加到收藏夹

Review Oncology

Targeted inhibitors and antibody immunotherapies: Novel therapies for paediatric leukaemia and lymphoma

Erica Brivio, Andre Baruchel, Auke Beishuizen, Jean-Pierre Bourquin, Patrick A. Brown, Todd Cooper, Lia Gore, E. Anders Kolb, Franco Locatelli, Shannon L. Maude, Francis J. Mussai, Britta Vormoor-Burger, Josef Vormoor, Arend von Stackelberg, C. Michel Zwaan

Summary: Despite improvements in treating newly diagnosed leukaemia and lymphoma in children, refractory or relapsed cases remain difficult to manage. Novel agents that offer less toxicity while maintaining efficacy are being explored. However, drug development for paediatric cancers lags behind adult therapeutic options.

EUROPEAN JOURNAL OF CANCER (2022)

添加到收藏夹

Article Oncology

CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment

Tessa Skroblyn, Jara J. Joedicke, Madlen Pfau, Kerstin Krueger, Jean-Pierre Bourquin, Shai Izraeli, Cornelia Eckert, Uta E. Hoepken

Summary: The study identified CXCL12-CXCR4 as the leading signaling axis for B-ALL cell migration and survival in the testicular leukemic niche. CXCR4 was found to be the only chemokine receptor robustly expressed on B-ALL cells in both diagnosis and relapse samples. Blocking CXCR4 functions showed promising results in preventing testicular infiltration and overall development of leukemia.

JOURNAL OF PATHOLOGY (2022)

添加到收藏夹

Article Oncology

Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution

Paulina Richter-Pechanska, Joachim B. Kunz, Tobias Rausch, Busra Erarslan-Uysal, Beat Bornhauser, Viktoras Frismantas, Yassen Assenov, Martin Zimmermann, Margit Happich, Caroline von Knebel-Doeberitz, Nils von Neuhoff, Rolf Kohler, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Renate Kirschner-Schwabe, Cornelia Eckert, Smadar Avigad, Stefan M. Pfister, Martina U. Muckenthaler, Jean-Pierre Bourquin, Jan O. Korbel, Andreas E. Kulozik

Summary: This study investigates the mechanisms of T-ALL relapse and reveals fundamentally different mechanisms driving type-1 and type-2 relapses. Type-1 relapses are characterized by IL7R upregulation, while type-2 relapses involve constitutional cancer predisposition gene mutations, genetic and epigenetic remodeling, and somatic hypermutator phenotypes. The study also finds that T-ALLs that later develop into type-2 relapses already have complex subclonal architecture even at the time of initial diagnosis.

LEUKEMIA (2022)

添加到收藏夹

Letter Hematology

Molecular complete remission following combination treatment of daratumumab and venetoclax in an adolescent with relapsed mixed phenotype acute leukemia

Martin Stanulla, Denis M. M. Schewe, Beat Bornhauser, Jean-Pierre Bourquin, Cornelia Eckert, Wolfgang Eberl, Saskia Wolf, Julian Wolf, Fotini Vogiatzi, Anke K. K. Bergmann, Gunnar Cario, Rita Beier, Martin Sauer, Christian P. P. Kratz, Britta Maecker-Kolhoff

ANNALS OF HEMATOLOGY (2023)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Functional analysis of structural variants in single cells using Strand-seq

Hyobin Jeong, Karen Grimes, Kerstin K. Rauwolf, Peter-Martin Bruch, Tobias Rausch, Patrick Hasenfeld, Eva Benito, Tobias Roider, Radhakrishnan Sabarinathan, David Porubsky, Sophie A. Herbst, Busra Erarslan-Uysal, Johann-Christoph Jann, Tobias Marschall, Daniel Nowak, Jean-Pierre Bourquin, Andreas E. Kulozik, Sascha Dietrich, Beat Bornhauser, Ashley D. Sanders, Jan O. Korbel

Summary: This study introduces a computational method called scNOVA, which utilizes Strand-seq to analyze structural variations in single cells and infer gene expression. The research reveals the impact of structural variations on gene regulation and signaling pathways, and successfully applies the method to the study of chronic lymphocytic leukemia and T cell acute lymphoblastic leukemia.

NATURE BIOTECHNOLOGY (2023)

添加到收藏夹

Article Engineering, Biomedical

Microphysiological Drug-Testing Platform for Identifying Responses to Prodrug Treatment in Primary Leukemia

Furkan Gokce, Alicia Kaestli, Christian Lohasz, Martina de Geus, Hans-Michael Kaltenbach, Kasper Renggli, Beat Bornhauser, Andreas Hierlemann, Mario Modena

Summary: Despite improving survival rates in pediatric leukemia patients, the outcome for certain subtypes remains poor. A microphysiological drug-testing platform has been developed to address the limitations of current screening methods, allowing for the co-culture of patient-derived leukemia cells, bone marrow cells, and liver tissues. By testing the activation of the prodrug ifosfamide in this platform, sample-specific sensitivities to ifosfamide in primary leukemia samples can be identified, providing potential for precision chemotherapy selection.

ADVANCED HEALTHCARE MATERIALS (2023)

添加到收藏夹

Article Biochemical Research Methods

MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling

Yun Huang, Aneta Drakul, Jasmeet Sidhu, Kerstin K. Rauwolf, James Kim, Beat Bornhauser, Jean-Pierre Bourquin

Summary: Mesenchymal stromal cells (MSCs) play a crucial role in regulating hematopoiesis and may also support cancer cells in evading therapy. This study engineered MSCs to express a synthetic CD19-sensor receptor, allowing for ex vivo drug response profiling of primary CD19+ leukemia cells.

SLAS DISCOVERY (2023)

添加到收藏夹

Article Hematology

B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow

Malwine J. Barz, Lena Behrmann, Danaelle Capron, Gabriele Zuchtriegel, Fabio D. Steffen, Leo Kunz, Yang Zhang, Iria Jimenez Vermeerbergen, Blerim Marovca, Moritz Kirschmann, Antonia Zech, Cesar Nombela-Arrieta, Urs Ziegler, Timm Schroeder, Beat Bornhauser, Jean -Pierre Bourquin

Summary: Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). Bone marrow microenvironment plays a role in treatment resistance. By using three-dimensional fluorescence imaging, specific sites in the bone marrow were identified where B-cell precursor ALL cells and T-ALL cells preferentially reside and interact with different components of the microenvironment. These lineage-dependent differences suggest potential targets for improving treatment.

HAEMATOLOGICA (2023)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.