期刊
LEUKEMIA & LYMPHOMA
卷 50, 期 10, 页码 1699-1708出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428190903189035
关键词
Non-Hodgkin lymphoma; classification; heterogeneity; B-cell receptor
资金
- Ministerio de Sanidad y Consumo [G03/179, PI051623, PI052800]
- Ministerio de Ciencia y Tecnologia [SAF200500221, BIO 2005-01078, SAF2008-03871]
- Fundacion la Caixa, Spain
- National Institute of Bioinformatics
Gene-expression profiling in B-cell lymphomas has provided crucial data on specific lymphoma types, which can contribute to the identification of essential lymphoma survival genes and pathways. In this study, the gene-expression profiling data of all major B-cell lymphoma types were analyzed by unsupervised clustering. The transcriptome classification so obtained, was explored using gene set enrichment analysis generating a heatmap for B-cell lymphoma that identifies common lymphoma survival mechanisms and potential therapeutic targets, recognizing sets of coregulated genes and functional pathways expressed in different lymphoma types. Some of the most relevant signatures (stroma, cell cycle, B-cell receptor (BCR)) are shared by multiple lymphoma types or subclasses. A specific attention was paid to the analysis of BCR and coregulated pathways, defining molecular heterogeneity within multiple B-cell lymphoma types.
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