Article
Pharmacology & Pharmacy
Natsumi Mizuno, Yoshiki Yanagawa
Summary: In this study, it was found that tofacitinib enhanced IFN-gamma-induced MHC II expression in macrophages by transcriptional regulation through induction of CIITA, while decreasing the expression of CD86.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kishore Nagasubramanian, Shanker Jha, Anuranjan Singh Rathore, Krishnakant Gupta
Summary: The study aimed to identify potential modulators for CIITA-I by predicting its structure, docking with small molecule databases, and conducting molecular simulations. Two potential modulators, ZINC5154833 and F5254-0161, were identified based on their interaction strength with CIITA-I.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Immunology
Steven X. Cho, Saptha Vijayan, Ji-Seung Yoo, Toshiyuki Watanabe, Ryota Ouda, Ning An, Koichi S. Kobayashi
Summary: The presentation of antigenic peptides by MHC class I and class II molecules is crucial for activating the adaptive immune system, with CIITA and NLRC5 serving as the major transcriptional activators of MHC class II and class I gene expression. Recent advances in understanding the role of NLRC5 in infectious diseases and cancer have shed light on its biological significance and mechanism in MHC class I expression.
Review
Cell Biology
Irina A. Ishina, Maria Y. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov, Alexey A. A. Belogurov Jr, Alexander G. G. Gabibov
Summary: Antigen presentation by MHC-II is crucial for immune response and self-antigen tolerance. Certain MHC-II alleles are associated with autoimmune diseases. The process of MHC-II-mediated presentation plays a significant role in understanding the mechanisms of autoimmune diseases and the protective effect of certain MHC-II alleles.
Article
Pediatrics
Ramesh Radhika, Milind S. Tullu, Sunil Karande, Umair Ahmed Bargir
Summary: Major Histocompatibility Complex (MHC) Class II deficiency is a rare autosomal recessive primary immunodeficiency caused by mutations in regulatory genes of MHC Class II proteins. This case report describes a 9-month-old girl presenting with repeated pneumonia, lymphocytopenia, and absence of HLA-DR expression on B cells, which led to the diagnosis of MHC Class II deficiency. Genetic analysis identified a homozygous mutation in the RFX-5 gene. Despite the patient's unfortunate outcome, the importance of prenatal diagnosis was emphasized to the parents.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Wei Huang, Kara L. Dicks, Keith T. Ballingall, Susan E. Johnston, Alexandra M. Sparks, Kathryn Watt, Jill G. Pilkington, Josephine M. Pemberton
Summary: The study found no association between MHC class II variation and weight or strongyle faecal egg count, but did find associations with immunoglobulin levels which varied with isotype, age and sex. This suggests that associations between MHC and phenotypic traits are more likely to be found for traits more closely associated with pathogen defense than integrative traits such as bodyweight in wild populations.
Article
Immunology
Miranda Houtman, Espen Hesselberg, Lars Ronnblom, Lars Klareskog, Vivianne Malmstrom, Leonid Padyukov
Summary: HLA-DRB1 alleles have been associated with autoimmune diseases, particularly for RA. Genetically pre-selected healthy individuals show differential expression of HLA-DRB and HLA-DQ in immune cells, with a strong cis effect on gene expression seen in individuals carrying HLA-DRB1 SE-positive alleles.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dominik W. Schmid, Magdalena Meyer, Kerstin Wilhelm, Tatiana Tilley, Thomas Link-Hessing, Ramona Fleischer, Ebenezer K. Badu, Evans Ewald Nkrumah, Samuel Kingsley Oppong, Nina Schwensow, Marco Tschapka, Heather J. Baldwin, Peter Vallo, Victor M. Corman, Christian Drosten, Simone Sommer
Summary: Understanding the immunogenetic basis of coronavirus susceptibility in major pathogen reservoirs, such as bats, is crucial for inferring their zoonotic potential.
Article
Rheumatology
Shanshan Zhang, Hideaki Tsuji, Hui Jin, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Masao Tanaka, Hisashi Arase, Koichiro Ohmura, Akio Morinobu
Summary: This study found that the heavy chain of IgG (IgGH) recognizes the RA-susceptible HLA class II molecule complex through RF. Various types of IgGH segments were synthesized and transfected into human embryonic kidney 293T cells to examine their surface expression and RF recognition. The results showed that the C(H)1 domain of IgGH specifically binds to RA-susceptible HLA-DR molecule and is expressed on the cell surface. RF specifically recognizes the C(H)3 domain of the IgGH/HLA-DR4 complex.
Article
Medicine, Research & Experimental
Shivai Gupta, Danmeng Li, David A. Ostrov, Cuong Q. Nguyen
Summary: This study proposes a novel therapeutic approach for SjS by blocking MHC class II I-Ag-7 antigen presentation in NOD mice. The results demonstrate that treating NOD mice with TATD or 8-Azaguanine can alleviate SjS symptoms and reduce the severity of the disease.
Article
Immunology
Xiaobing Lu, Wenxi Li, Jiasen Guo, Peng Jia, Wanwan Zhang, Meisheng Yi, Kuntong Jia
Summary: This study demonstrates that viral infection inhibits the expression of MHC-II and interferon-induced genes, disrupting antigen presentation and immune response. The viral protein N interacts with STAT1, leading to its degradation and inhibition of biological function. These findings suggest that aquatic viruses, like mammalian viruses, can evade the host immune system by interfering with antigen presentation.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Marion Rambault, Florence B. Gilbert, Philippe Roussel, Alexia Tessier, Pierre Germon, Nathalie Winter, Aude Remot
Summary: Bovine mastitis, caused by bacterial infection, not only leads to economic losses and health problems in animals, but also affects their welfare. Neutrophils play a crucial role in eliminating pathogens and are responsible for the increase in somatic cell count during mastitis. Recent research reveals that a subset of neutrophils expressing major histocompatibility complex class II have regulatory capacities in cattle, providing new insights into the immune response during mastitis.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Immunology
Taushif Khan, Mahbuba Rahman, Ikhlak Ahmed, Fatima Al Ali, Puthen Veettil Jithesh, Nico Marr
Summary: This study explored the genetic variation of HLA class II genes in a cohort of Arab adults and found a strong association between zygosity of HLA class II genes and antibody responses to common pathogens. The results suggest that HLA class II gene polymorphisms confer specific humoral immunity against common pathogens, contributing to the genetic diversity of HLA class II loci during human evolution.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Guan K. Tay, Halima Al Naqbi, Aurelie Mawart, Zahrah Baalfaqih, Anoud Almaazmi, Asma Deeb, Habiba Alsafar
Summary: In this study, classical Human Leucocyte Antigen (HLA) class II haplotypes associated with type 1 diabetes (T1D) were identified in five families from the United Arab Emirates (UAE). Segregation analyses were performed to assess the risk of T1D in families with specific HLA-DR4 and HLA-DR3 haplotypes, providing insight into the genetics of T1D in the understudied population of the UAE.
FRONTIERS IN GENETICS
(2021)
Review
Immunology
Anne M. Macy, Lauren M. Herrmann, Anngela C. Adams, K. Taraszka Hastings
Summary: Major histocompatibility complex class-II-restricted presentation by nonprofessional antigen-presenting cells in the tumor microenvironment plays a role in regulating antitumor T-cell responses. In murine models, tumor cell-specific MHC class II expression reduction inhibits tumor growth in vivo, dependent on T cells. Tumor cell-specific MHC class II expression is associated with improved survival and response to immune checkpoint inhibitors in human cancers. Antigen-presenting cancer-associated fibroblasts (apCAF) activate CD4 T cells by presenting MHC class-II-restricted antigens. The effect of MHC class II on apCAFs depends on the cell of origin. MHC class II on tumoral lymphatic endothelial cells leads to regulatory T cell expansion and increased in vivo tumor growth.
CURRENT OPINION IN IMMUNOLOGY
(2023)
Article
Hematology
Elaine S. Jaffe, John K. C. Chan
Summary: In this study, Kemps et al provide an expanded understanding of the pathological, genomic, and clinical features of ALK-positive histiocytosis, and show the clinical efficacy of ALK inhibition in patients with central or peripheral nervous system disease, with durable responses in all cases.
Review
Medicine, General & Internal
Marco M. Buhler, Jose Martin-Subero, Qiang Pan-Hammarstrom, Elias Campo, Richard Rosenquist
Summary: Histopathologic examination is important for the diagnosis of lymphoid malignancies, but recent advances in high-throughput technologies have improved our understanding of these tumors. Certain genomic alterations can provide diagnostic information and others can indicate prognosis or treatment response. Comprehensive molecular profiling may pave the way for precision diagnostics and medicine.
JOURNAL OF INTERNAL MEDICINE
(2022)
Editorial Material
Hematology
Saber Tadros, Elaine S. Jaffe
Article
Hematology
Elias Campo, Elaine S. Jaffe, James R. Cook, Leticia Quintanilla-Martinez, Steven H. Swerdlow, Kenneth C. Anderson, Pierre Brousset, Lorenzo Cerroni, Laurence de Leval, Stefan Dirnhofer, Ahmet Dogan, Andrew L. Feldman, Falko Fend, Jonathan W. Friedberg, Philippe Gaulard, Paolo Ghia, Steven M. Horwitz, Rebecca L. King, Gilles Salles, Jesus San-Miguel, John F. Seymour, Steven P. Treon, Julie M. Vose, Emanuele Zucca, Ranjana Advani, Stephen Ansell, Wing-Yan Au, Carlos Barrionuevo, Leif Bergsagel, Wing C. Chan, Jeffrey I. Cohen, Francesco d'Amore, Andrew Davies, Brunangelo Falini, Irene M. Ghobrial, John R. Goodlad, John G. Gribben, Eric D. Hsi, Brad S. Kahl, Won-Seog Kim, Shaji Kumar, Ann S. LaCasce, Camille Laurent, Georg Lenz, John P. Leonard, Michael P. Link, Armando Lopez-Guillermo, Maria Victoria Mateos, Elizabeth Macintyre, Ari M. Melnick, Franck Morschhauser, Shigeo Nakamura, Marina Narbaitz, Astrid Pavlovsky, Stefano A. Pileri, Miguel Piris, Barbara Pro, Vincent Rajkumar, Steven T. Rosen, Birgitta Sander, Laurie Sehn, Margaret A. Shipp, Sonali M. Smith, Louis M. Staudt, Catherine Thieblemont, Thomas Tousseyn, Wyndham H. Wilson, Tadashi Yoshino, Pier-Luigi Zinzani, Martin Dreyling, David W. Scott, Jane N. Winter, Andrew Zelenetz
Summary: Since 1994, the classification of lymphoid neoplasms has been continuously updated through international efforts, with recent progress driven by genomic studies. This proposal presents the International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors, which has refined diagnostic criteria and incorporated new insights from genomics.
Editorial Material
Hematology
Neval Ozkaya, Elaine S. Jaffe
Correction
Pathology
Birgitta Sander, Elias Campo, Eric D. Hsi
Review
Pathology
Birgitta Sander, Elias Campo, Eric D. Hsi
Summary: This manuscript reviews the clinicopathologic and biologic features of chronic lymphocytic leukaemia/small lymphocytic lymphoma, B-cell prolymphocytic leukaemia, and mantle cell lymphoma. Discussions focus on incorporating new knowledge into the next classification system.
Review
Pathology
Angela Guenther, Anne Tierens, Agnieszka Malecka, Jan Delabie
Summary: Primary cold agglutinin disease is a type of autoimmune hemolytic anemia caused by circulating antibodies against I antigen. It has been recognized as a distinct B-cell lymphoproliferative disease and has been included in the most recent classifications of mature B-cell neoplasms.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Letter
Pathology
Neval Ozkaya, Ina Lee, Terrica S. Johnson, Elaine S. Jaffe
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Letter
Hematology
Ting Zhou, Constance M. Yuan, Kathryn Lurain, Maryalice Stetler-Stevenson, Armando C. Filie, Stefania Pittaluga, Elaine S. Jaffe, Ramya Ramaswami, Robert Yarchoan, Hao-Wei Wang
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Pathology
Elaine S. Jaffe
Summary: The modern taxonomy of disease provides a framework for precision medicine that integrates traditional pathologic criteria with clinical and genomic features. Follicular lymphoma (FL) and diffuse large B-cell lymphoma are the two most common subtypes of lymphoma worldwide. Recent studies have revealed significant diversity among follicle center-derived lesions, and diffuse large B-cell lymphoma is a family of aggressive B-cell neoplasms with varied pathogenesis and clinical features. High-throughput sequencing has identified diverse mutational profiles that can guide targeted therapy and improve patient outcomes in the future.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Editorial Material
Hematology
James D. Phelan, Elaine S. Jaffe
Summary: In this study, the authors used whole genome sequencing to investigate the basis of follicular lymphoma (FL) transformation. They identified two genetically distinct subgroups of FL, dFL and cFL, which showed a significant difference in time to transformation.
Editorial Material
Hematology
Yanna Ding, Elaine S. Jaffe
Article
Hematology
Anna Keogh, Fiona Lynott, Antonios Papanicolau-Sengos, Mutaz Mohammed Nur, Aisling Spillane, Fiona Quinn, Ezzat ElHassadi, Elaine S. S. Jaffe, Richard Flavin
Summary: Nodal peripheral T cell lymphoma with T follicular helper cell phenotype is an aggressive lymphoma that responds poorly to conventional treatments. The minimum criteria for diagnosis and distinct histological features have not been well described.
HEMATOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Amna Farooq, Gunhild Troen, Jan Delabie, Junbai Wang
Summary: This study proposes a novel methodology to investigate genome-wide gene regulatory mechanisms in cancer by combining genetic and epigenetic factors. The research identifies key genes and mutations associated with follicular lymphoma, providing valuable insights for the development of new treatment strategies.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
