BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

(2011) A. Hamilton et al.   BLOOD

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

Mechanism of USP7/HAUSP Activation by Its C-Terminal Ubiquitin-like Domain and Allosteric Regulation by GMP-Synthetase

(2011) Alex C. Faesen et al.   MOLECULAR CELL

A continuum model for tumour suppression

(2011) Alice H. Berger et al.   NATURE

Morgana/chp-1, a ROCK Inhibitor Involved in Centrosome Duplication and Tumorigenesis

(2010) Roberta Ferretti et al.   DEVELOPMENTAL CELL

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

(2010) Amie S. Corbin et al.   JOURNAL OF CLINICAL INVESTIGATION

BCR-ABL kinase is dead; long live the CML stem cell

(2010) Alexander Perl et al.   JOURNAL OF CLINICAL INVESTIGATION

PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice

(2009) C. Peng et al.   BLOOD

A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell

(2009) Keisuke Ito et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Tenets of PTEN Tumor Suppression

(2008) Leonardo Salmena et al.   CELL

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE