Review
Immunology
Lauren A. Zenewicz
Summary: Cytokines, including IL-22, play crucial roles in inflammation, with their activity regulated by factors like IL-22BP. IL-22BP, a soluble receptor homolog, binds to IL-22 with greater affinity, impacting the biological functions of IL-22, yet further research is needed to fully understand its role and regulation mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Immunology
Jinzhi Duan, Juan D. Matute, Richard S. Blumberg
Summary: The research discovered that interleukin-22 (IL-22) has a regulatory effect on MHC class II expression in epithelial cells, with opposite impacts on chronic inflammatory disease and viral infection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Cell Biology
Antoine Freuchet, Apolline Salama, Severine Remy, Carole Guillonneau, Ignacio Anegon
Summary: IL-34 and CSF-1 play crucial roles in the survival and differentiation of monocytes/macrophages, with differences in receptor binding and signaling despite sharing similar structures. IL-34 has additional receptors and potential actions beyond monocyte/macrophages.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Oncology
Anastasios D. Giannou, Joran Luecke, Dorte Kleinschmidt, Ahmad Mustafa Shiri, Babett Steglich, Mikolaj Nawrocki, Tao Zhang, Dimitra E. Zazara, Jan Kempski, Lilan Zhao, Olympia Giannou, Theodora Agalioti, Leonie Brockmann, Franziska Bertram, Morsal Sabihi, Marius Boettcher, Florian Ewald, Kornelius Schulze, Johann von Felden, Andres Machicote, Ioannis C. Maroulis, Petra C. Arck, Julia-Kristin Grass, Baris Mercanoglu, Matthias Reeh, Stefan Wolter, Michael Tachezy, Hannes Seese, Myrto Theodorakopoulou, Panagis M. Lykoudis, Asmus Heumann, Faik G. Uzunoglu, Tarik Ghadban, Oliver Mann, Jakob R. Izbicki, Jun Li, Anna Dupree, Nathaniel Melling, Nicola Gagliani, Samuel Huber
Summary: The study aimed to investigate the role and mechanisms of IL-22 and IL-22BP signaling in liver cancer. The results showed that IL-22 promoted HCC development, while IL-22BP reduced tumor growth. IL-22 was mainly produced by a subset of T cells in HCC, while IL-22BP was abundantly secreted by neutrophils. Hepatocytes were identified as a major target of this pathological IL-22 signaling.
Review
Hematology
Robert Zeiser, Yi-Bin Chen, Nader N. Youssef, Francis Ayuk
Summary: Acute graft-versus-host disease (aGVHD) is a severe complication after allogeneic haematopoietic cell transplantation, with gastrointestinal (GI) tract involvement (GI aGVHD) being a major cause of morbidity and mortality. Despite systemic steroids being the standard treatment for aGVHD, around 50% of patients do not respond to steroids, leading to poor outcomes. This review discusses the role of glucagon-like peptide 2 (GLP-2) in protecting and maintaining GI epithelial cells, as well as the potential use of the GLP-2 analogue apraglutide as an adjunctive treatment for GI aGVHD.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Longmei Shang, Maxwell Duah, Yan Xu, Yiwen Liang, Dong Wang, Fan Xia, Lingling Li, Zengtian Sun, Zhiling Yan, Kailin Xu, Bin Pan
Summary: This study found a positive correlation between plasma IL-22 levels and blood TRECs levels at days 14 and 28 posttransplant in humans. Higher plasma IL-22 levels, occurrence of aGVHD, and age were significantly associated with higher blood TRECs levels at day 28 after allotransplant. An increase in plasma IL-22 levels during days 14 and 28 was linked to faster recovery of blood TRECs and naive T-cell levels in recipients. High TRECs levels at day 28 were associated with lower incidence of aGVHD, regardless of IL-22 levels. Other factors like age and infection also impacted plasma IL-22 levels in allotransplant recipients.
Article
Oncology
Katiri J. Snyder, Hannah K. Choe, Yandi Gao, Natalie E. Sell, Kara M. Braunreiter, Nina C. Zitzer, Lotus Neidemire-Colley, Sonu Kalyan, Adrienne M. Dorrance, Andrea Keller, Maria M. Mihaylova, Satishkumar Singh, Lalit Sehgal, Gideon Bollag, Yan Ma, Ben Powell, Steven M. Devine, Parvathi Ranganathan
Summary: Acute graft-versus-host disease (GVHD) is a major cause of non-relapse mortality following allogeneic hematopoietic cell transplantation. Inhibiting BET proteins shows promise in improving survival and reducing disease progression in acute GVHD.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell & Tissue Engineering
Jingyi Shen, Ying Wang, Fei Zheng, Shuo Cao, Qiu Lan, Kailin Xu, Bin Pan
Summary: This study reveals the importance of aryl hydrocarbon receptor (AHR) in thymus regeneration and its regulation of IL-22RA1 expression. This has implications for improving thymus regeneration and controlling chronic graft-versus-host disease (cGVHD).
NPJ REGENERATIVE MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Jakub Rosik, Bartosz Szostak, Filip Machaj, Andrzej Pawlik
Summary: HLA matching, transplantation technique, or underlying disease greatly influences the probability of long-term transplantation success. Genetic variations affecting antigen presentation also contribute to solid organ transplantation and allogeneic haematopoietic stem cell transplantation outcomes. Studies suggest that some CTLA4 gene polymorphisms may impact acute graft rejection and transplantation outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Rachel E. Crossland, Jean Norden, Sakhila Ghimire, Mateja Kralj Juric, Kim F. Pearce, Clare Lendrem, Matthew Collin, Eva Mischak-Weissinger, Ernst Holler, Hildegard T. Greinix, Anne M. Dickinson
Summary: The study found that miR-155 and miR-146a were upregulated in gastrointestinal and skin tissue samples of aGvHD patients, and their expression levels in serum and urine samples were also associated with the risk of developing aGvHD. These results support the potential of miR-155 and miR-146a as biomarkers for aGvHD, but further investigation is needed to understand their role in generalized inflammation and specific pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Mizuki Watanabe, Junya Kanda, Takahiro Fukuda, Naoyuki Uchida, Kazuhiro Ikegame, Keisuke Kataoka, Hikaru Kobayashi, Takahide Ara, Jun Ishikawa, Ken-ichi Matsuoka, Yasuhiro Sugio, Hideyuki Nakazawa, Takashi Ikeda, Yoshiko Atsuta, Eisei Kondo, Ritsuro Suzuki
Summary: The impact of acute and chronic graft versus host disease (aGVHD, cGVHD) on lymphoma progression and transplant outcomes was studied in 2204 Japanese patients with non-Hodgkin lymphomas. While aGVHD/cGVHD had no statistical impact on lymphoma progression in the overall cohort, their impact was significant in certain groups. Limited cGVHD was associated with superior survival, while severe GVHDs showed negative impacts on them.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Editorial Material
Hematology
Mohamad Mohty, Florent Malard
Summary: This study evaluated the safety and efficacy of a novel recombinant human interleukin-22 (IL-22) dimer in combination with systemic corticosteroids for the treatment of newly diagnosed gastrointestinal acute graft-versus-host disease (GVHD). The results showed that the overall response rate of the treatment group at day 28 was 70%.
Article
Medicine, Research & Experimental
Kaijun Wang, Miao Zhou, Hongbin Si, Jie Ma
Summary: Low-grade chronic inflammation, also known as metabolic inflammation, promotes the development of metabolic diseases. Changes in gut microbes and metabolites can reduce inflammation via IL-22, highlighting the potential of IL-22 as a therapeutic target for the management of metabolic inflammation and related diseases.
Article
Multidisciplinary Sciences
Hung-Yu Chiang, Hsueh-Han Lu, Janaki N. Sudhakar, Yu-Wen Chen, Nien-Shin Shih, Yi-Ting Weng, Jr-Wen Shui
Summary: IL-22 induces IL-18 expression by intestinal epithelial cells, and IL-18 plays an important role in host defense against intestinal infection and inflammation.
NATURE COMMUNICATIONS
(2022)
Review
Genetics & Heredity
Martina Pitea, Filippo Antonio Canale, Gaetana Porto, Chiara Verduci, Giovanna Utano, Giorgia Policastro, Caterina Alati, Ludovica Santoro, Lucrezia Imbalzano, Massimo Martino
Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a challenging treatment modality for hematologic diseases, but graft-versus-host disease (GVHD) remains a common and significant complication. Recent studies have shown that microRNAs (miRNAs) play a key role in the biology of GVHD and may have potential value in early diagnosis and disease monitoring.
Article
Biophysics
Sebastian Giebel, Myriam Labopin, Mohamed Houhou, Denis Caillot, Juergen Finke, Didier Blaise, Nathalie Fegueux, Mark Ethell, Jan J. Cornelissen, Edouard Forcade, Ibrahim Yakoub-Agha, Federico Lussana, Johan Maertens, Jean Henri Bourhis, Pavel Jindra, Norbert Claude Gorin, Arnon Nagler, Mohamad Mohty
Summary: For elderly patients with acute lymphoblastic leukemia (ALL) in first complete remission (CR1), autologous hematopoietic cell transplantation (auto-HCT) may be considered as an alternative to reduced intensity conditioning allogeneic HCT (RIC-allo-HCT). A retrospective study compared outcomes of RIC-allo-HCT from matched sibling donors (MSD) or matched unrelated donors (MUD) with auto-HCT for patients aged 55 years or more. While the probabilities of leukemia-free survival (LFS) and overall survival (OS) were not significantly different between RIC-allo-HCT and auto-HCT, the risk of non-relapse mortality (NRM) was higher for both MSD-HCT and MUD-HCT, and for MUD-HCT, the chance of LFS and OS was lower.
BONE MARROW TRANSPLANTATION
(2023)
Letter
Biophysics
Tamim Alsuliman, Nicolas Stocker, Elise Corre, Remy Dulery, Simona Sestili, Laure Ricard, Florent Malard, Mohamad Mohty, Paul Coppo, Zora Marjanovic
Summary: Patients with high-risk lymphoma received R-COPADM and CYVE treatment, followed by ASCT if suitable. The study showed the efficacy and acceptable safety profile of this regimen, with a 87% overall survival rate and a 83% progression-free survival rate at 46 months of follow-up. These results suggest the potential benefit of this treatment approach for high-risk lymphoma patients.
BONE MARROW TRANSPLANTATION
(2023)
Letter
Hematology
Dai Chihara, Luuk Gras, Nienke Zinger, Nicolaus Kroeger, Jiri Mayer, Jakob Passweg, Regis Peffault de Latour, Jenny Byrne, William Krueger, Jan-Paul Bohn, Uwe Platzbecker, Igor Wolfgang Blau, Francesca Bonifazi, Grzegorz Helbig, Andrew McDonald, Martin Mistrik, Mohamad Mohty, Ron Ram, Jaime Sanz, Carlos Vallejo Llamas, Robert J. Kreitman, Patrick J. Hayden, Donal McLornan, Olivier Tournilhac, Michel van Gelder, Ibrahim Yakoub-Agha
Article
Hematology
Alexandros Spyridonidis, Myriam Labopin, Bipin Savani, Sebastian Giebel, Gesine Bug, Stefan Schoenland, Nicolaus Kroeger, Matthias Stelljes, Thomas Schroeder, Andrew McDonald, Igor-Wolfgang Blau, Martin Bornhaeuser, Montse Rovira, Wolfgang Bethge, Andreas Neubauer, Arnold Ganser, Jean Henri Bourhis, Matthias Edinger, Bruno Lioure, Gerald Wulf, Kerstin Schaefer-Eckart, Mutlu Arat, Zinaida Peric, Christoph Schmid, Ali Bazarbachi, Fabio Ciceri, Arnon Nagler, Mohamad Mohty
Summary: In this registry-based study, the outcomes of allogeneic hematopoietic cell transplantation (allo-HCT) in adult patients with acute lymphoblastic leukemia (ALL) were compared. The study found that the total dose of total body irradiation (TBI) did not influence the survival outcomes for patients, regardless of whether they received a standard 12-Gray or lower 8-Gray dose.
Article
Hematology
Gerard Socie, Dietger Niederwieser, Nikolas von Bubnoff, Mohamad Mohty, Jeff Szer, Reuven Or, James Garrett, Anirudh Prahallad, Celine Wilke, Robert Zeiser
Summary: Systemic steroids are the first-line treatment for acute graft-versus-host disease, but about 50% of patients become steroid-refractory or dependent. Ruxolitinib is the only approved therapy for these patients and has shown superior efficacy compared with the best available therapy in a clinical trial.
Editorial Material
Hematology
Mohamad Mohty, Florent Malard
Summary: This study evaluated the safety and efficacy of a novel recombinant human interleukin-22 (IL-22) dimer in combination with systemic corticosteroids for the treatment of newly diagnosed gastrointestinal acute graft-versus-host disease (GVHD). The results showed that the overall response rate of the treatment group at day 28 was 70%.
Review
Biophysics
Mohamad Mohty, Florent Malard, Ahmed S. Alaskar, Mahmoud Aljurf, Mutlu Arat, Peter Bader, Frederic Baron, Ali Bazarbachi, Didier Blaise, Eolia Brissot, Fabio Ciceri, Selim Corbacioglu, Jean-Hugues Dalle, Fiona Dignan, Anne Huynh, Michelle Kenyon, Arnon Nagler, Antonio Pagliuca, Zinaida Peric, Paul G. Richardson, Annalisa Ruggeri, Tapani Ruutu, Ibrahim Yakoub-Agha, Rafael F. Duarte, Enric Carreras
Summary: Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can occur after hematopoietic cell transplantation (HCT). The European Society for Blood and Marrow Transplantation (EBMT) has recently updated the definition and severity grading system for SOS/VOD in adult patients. The aim of this work is to provide an update on the diagnosis, severity assessment, pathophysiology, and treatment of SOS/VOD in adult patients.
BONE MARROW TRANSPLANTATION
(2023)
Article
Biophysics
Arnon Nagler, Myriam Labopin, Ryszard Swoboda, Alexander Kulagin, Helene Labussiere-Wallet, Montserrat Rovira, Didier Blaise, Jan Vydra, Ibrahim Yakoub-Agha, Goda Choi, Peter Remenyi, Yener Koc, Jaime Sanz, Fabio Ciceri, Mohamad Mohty
Summary: Retrospective evaluation of transplant outcomes in adult AML patients undergoing allo-HCT in CR2 showed that post-transplant cyclophosphamide is an effective method for GVHD prophylaxis.
BONE MARROW TRANSPLANTATION
(2023)
Article
Biophysics
Frederic Baron, Annalisa Ruggeri, Christophe Peczynski, Myriam Labopin, Jean-Henri Bourhis, Mauricette Michallet, Patrice Chevallier, Jaime Sanz, Edouard Forcade, Riccardo Saccardi, Victoria Potter, Eliane Gluckman, Arnon Nagler, Mohamad Mohty
Summary: This study assessed the outcomes of patients who experienced graft failure after umbilical cord blood transplantation (CBT). It included a total of 87 patients and found that the cumulative incidence of relapse and nonrelapse mortality at 1-year was 35% and 37% respectively. Among patients who underwent salvage second transplantation, the 1-year and 2-year overall survival rates were 41% and 34% respectively. The study also identified complete remission and reduced-intensity conditioning as factors associated with better overall survival.
BONE MARROW TRANSPLANTATION
(2023)
Article
Hematology
Arnon Nagler, Myriam Labopin, Bhagirathbhai Dholaria, Didier Blaise, Sergey Bondarenko, Jan Vydra, Goda Choi, Montserrat Rovira, Peter Remenyi, Ellen Meijer, Claude Eric Bulabois, J. L. Diez-Martin, Ibrahim Yakoub-Agha, Eolia Brissot, Alexandros Spyridonidis, Jaime Sanz, Amit Patel, Mutlu Arat, Ali Bazarbachi, Gesine Bug, Bipin N. Savani, Sebastian Giebel, Fabio Ciceri, Mohamad Mohty
Summary: In this study, the impact of measurable residual disease (MRD) on the outcomes of post-transplant cyclophosphamide (PTCy)-based allo-HCT in acute myeloid leukemia (AML) patients in first complete remission (CR1) was assessed. The results showed that MRD positive (MRD+) patients had higher relapse rates and lower survival rates compared to MRD negative (MRD-) patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Hematology
Florent Malard, Mohamad Mohty
Summary: Chronic graft-versus-host disease (cGvHD) is a major complication of allogeneic hematopoietic cell transplantation (allo-HCT), but significant progress has been made in the last decade. Advances in understanding cGvHD pathways have led to targeted therapy with novel drugs, reducing the need for harmful corticosteroids and improving quality of life and overall survival. The management of steroid-refractory cGvHD has recently improved with the approval of ibrutinib, ruxolitinib, and belumosudil for patients who have failed previous treatments.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Biophysics
Tapani Ruutu, Christophe Peczynski, Mohamed Houhou, Emmanuelle Polge, Mohamad Mohty, Nicolaus Kroeger, Ivan Moiseev, Olaf Penack, Nina Salooja, Helene Schoemans, Rafael F. Duarte, Thomas Schroeder, Jakob Passweg, Gerald G. Wulf, Arnold Ganser, Simona Sica, Mutlu Arat, Urpu Salmenniemi, Annoek E. C. Broers, Jean Henri Bourhis, Alessandro Rambaldi, Johan Maertens, Kazimierz Halaburda, Tsila Zuckerman, Helene Labussiere-Wallet, Grzegorz Basak, Christian Koenecke, Zinaida Peric
Summary: The study investigated the incidence, diagnostic policy, management, and outcome of VOD/SOS at EBMT centers. It included 71 participating centers with a total of 2886 allogeneic transplantations and 93 cases of VOD/SOS in 2018. The findings showed a low incidence of VOD/SOS and a predominance of severe and very severe grades, indicating the importance of early diagnosis and treatment to improve outcomes.
BONE MARROW TRANSPLANTATION
(2023)
Letter
Biophysics
Florent Malard, Giorgia Battipaglia, Beatrice Gaugler, Lama Siblany, Zoe van de Wyngaert, Agnes Bonnin, Remy Dulery, Anne Banet, Nicolas Stocker, Laure Ricard, Eolia Brissot, Mohamad Mohty
BONE MARROW TRANSPLANTATION
(2023)
Letter
Biophysics
Giorgia Battipaglia, Jarl E. Mooyaart, Ralf Meyer, Mohamad Mohty, Alicja Sadowska-Klasa, Oleg Goloshchapov, Franco Locatelli, Jan Styczynski, Jiri Pavlu, Jaroslaw Dybko, Gleb Bronin, Urpu Salmenniemi, Pavel Jindra, Jorinde D. Hoogenboom, Jurgen Kuball, Annalisa Ruggeri, Florent Malard
BONE MARROW TRANSPLANTATION
(2023)
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)