Article
Hematology
Marina Lafage-Pochitaloff, Bastien Gerby, Veronique Baccini, Laetitia Largeaud, Vincent Fregona, Nais Prade, Pierre-Yves Juvin, Laura Jamrog, Pierre Bories, Sylvie Hebrard, Stephanie Lagarde, Veronique Mansat-De Mas, Oliver M. Dovey, Kosuke Yusa, George S. Vassiliou, Joop H. Jansen, Tobias Tekath, David Rombaut, Genevieve Ameye, Carole Barin, Audrey Bidet, John Boudjarane, Marie-Agnes Collonge-Rame, Carine Gervais, Antoine Ittel, Christine Lefebvre, Isabelle Luquet, Lucienne Michaux, Nathalie Nadal, Helene A. Poirel, Isabelle Radford-Weiss, Benedicte Ribourtout, Steven Richebourg, Stephanie Struski, Christine Terre, Isabelle Tigaud, Dominique Penther, Virginie Eclache, Michaela Fontenay, Cyril Broccardo, Eric Delabesse
Summary: This study investigated 113 cases of MDS and MDS/MPN with del(11q), revealing clinical features such as female predominance, similar survival prognosis to other MDS, low monocyte count, and abnormal megakaryopoiesis. The study also identified the common deleted region at 11q23.2, which is located between CADM1 and NXPE2 genes.
Article
Cell Biology
Christine Engelmann, Patrick Schuhmachers, Hana Zdimerova, Sanamjeet Virdi, Mathias Hauri-Hohl, Jana Pachlopnik Schmid, Adam Grundhoff, Rebecca A. Marsh, Wendy Wei-Lynn Wong, Christian Muenz
Summary: XLP is caused by loss of SAP or XIAP. Inhibition of XIAP leads to loss of B cells and decrease in viral titers and lymphomagenesis in humanized mice. Memory B cell loss is also observed in patients with XIAP deficiency.
CELL DEATH & DISEASE
(2022)
Article
Hematology
Shingo Nakahata, Syahrul Chilmi, Ayako Nakatake, Kuniyo Sakamoto, Maki Yoshihama, Ichiro Nishikata, Yoshinori Ukai, Tadashi Matsuura, Takuro Kameda, Kotaro Shide, Yoko Kubuki, Tomonori Hidaka, Akira Kitanaka, Akihiko Ito, Shigeki Takemoto, Nobuaki Nakano, Masumichi Saito, Masako Iwanaga, Yasuko Sagara, Kosuke Mochida, Masahiro Amano, Kouichi Maeda, Eisaburo Sueoka, Akihiko Okayama, Atae Utsunomiya, Kazuya Shimoda, Toshiki Watanabe, Kazuhiro Morishita
Summary: This study demonstrated that plasma sCADM1 concentrations gradually increased during disease progression from indolent to aggressive ATLL, and sCADM1 was identified as a specific biomarker for aggressive ATLL. sCADM1 is not only useful for monitoring response to chemotherapy and predicting relapse of ATLL, but also for distinguishing between ATLL and other inflammatory diseases such as HAM/TSP.
Article
Immunology
Mohadeseh Zarei Ghobadi, Elaheh Afsaneh, Rahman Emamzadeh
Summary: Adult T-cell leukemia/lymphoma (ATLL) is a cancer caused by human T-cell leukemia virus type 1 infection. We used a combination of differential co-expressed genes (DiffCoEx) and support vector machine-recursive feature elimination with cross-validation (SVM-RFECV) algorithms to categorize ATLL subtypes. The results identified specific genes for each subtype and reliable biomarkers for different ATLL subtypes.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yanuar Rahmat Fauzi, Shingo Nakahata, Syahrul Chilmi, Tomonaga Ichikawa, Phawut Nueangphuet, Ryoji Yamaguchi, Tatsufumi Nakamura, Kazuya Shimoda, Kazuhiro Morishita
Summary: Chloroquine (CQ) or hydroxychloroquine (HCQ) as autophagy inhibitors show potential therapeutic effects in the treatment of ATLL, by inhibiting cell proliferation and inducing apoptosis through blocking p47 degradation.
Article
Cell Biology
Hongxu Li, Jie Gao, Shuijun Zhang
Summary: CADM1, a cell adhesion molecule, plays a crucial role in tumor development by regulating apoptosis and malignant proliferation of tumor cells. It participates in regulating multiple signaling pathways with cell cycle-related proteins, inhibiting tumor invasion and migration. It could be a potential biomarker for early cancer diagnosis and a target for cancer treatment in future clinical practices.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Hongxu Li, Jie Gao, Shuijun Zhang
Summary: CADM1, a cell adhesion molecule, plays a regulatory role in tumor development by promoting tumor cell apoptosis and inhibiting malignant proliferation. Low CADM1 expression is associated with aggressive tumors and poor prognosis, and CADM1 functions differently in various cancer types.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Virology
Xiaorui Zuo, Ruoning Zhou, Sikai Yang, Guangyong Ma
Summary: HTLV-1 is an oncogenic retrovirus that mainly persists in the infected host cell as a provirus; it also causes a malignancy called adult T-cell leukemia/lymphoma (ATLL) in about 5% of infection. HTLV-1 replication is silent in vivo and relies on clonal proliferation of infected T cells for viral propagation. The mechanism of leukemic clone formation and ATLL onset during HTLV-1 infection is still unclear. This review summarizes the current understanding of HTLV-1 persistence and oncogenesis, incorporating recent cutting-edge discoveries obtained by high-throughput sequencing.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Oncology
Kazuhiro Morishita, Shingo Nakahata, Tomonaga Ichikawa
Summary: NDRG2 is a stress-responsive protein that maintains cell homeostasis by regulating stress-related signaling pathways. It forms a complex with PP2A to regulate signal transduction, and its loss of expression may lead to tumor development.
Article
Biochemistry & Molecular Biology
Mohsen Ghorbanzadeh Neghab, Mohammad Jalili-Nik, Arash Soltani, Amir R. Afshari, Seyed Mahdi Hassanian, Houshang Rafatpanah, Seyed Abdolrahim Rezaee, Hamid R. Sadeghnia, Sajad Ataei Azimi, Baratali Mashkani
Summary: This study investigated the levels of AKT, mTOR, and PI3K in ATLL cells, HTLV-1 infected cells, and HTLV-1 infected patients. The results showed downregulation of Akt/PI3K/mTOR mRNA expression but an increase in phosphorylated and activated forms of AKT and mTOR. Treatment with inhibitors decreased phosphorylation forms and restored mRNA expression levels. Rigosertib was more effective in inducing cell cycle arrest and apoptosis.
Article
Neurosciences
Natasha Sukhanov, Anya Vainshtein, Yael Eshed-Eisenbach, Elior Peles
Summary: Cell adhesion proteins of the Cadm family play a crucial role in myelination and axonal organization. The study reveals that Cadm3 is the main axonal ligand for glial Cadm4, and the combined action of Cadm2 and Cadm1 can compensate for its absence. Genetic ablation of all three Cadm genes phenocopies the abnormalities detected in the absence of Cadm4, indicating their interplay in regulating myelination and axonal organization.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Immunology
Diwei Zheng, Xindong Wang, Lin Cheng, Le Qin, Zhiwu Jiang, Ruocong Zhao, Yao Li, Jingxuan Shi, Qiting Wu, Youguo Long, Suna Wang, Zhaoyang Tang, Wei Wei, Jie Yang, Yangqiu Li, Hongsheng Zhou, Qifa Liu, Pentao Liu, Xinwen Chen, Yao Yao, LiHua Yang, Peng Li
Summary: Anti-CCR8 CAR T cells demonstrate potent antitumor activity against ATLL and CCR8(+) tumors, providing a promising therapeutic approach for ATLL and CCR8(+) tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rodrigo Pessoa, Daniela Raguer Valadao de Souza, Youko Nukui, Juliana Pereira, Lorena Abreu Fernandes, Rosa Nascimento Marcusso, Augusto Cesar Penalva de Oliveira, Jorge Casseb, Alberto Jose da Silva Duarte, Sabri Saeed Sanabani
Summary: Small RNAs are important epigenetic regulators in leukemias, including adult T-cell leukemia/lymphoma (ATLL). This study investigates the sRNA profile of a 30-year-old woman with ATLL at diagnosis and after maintenance therapy to correlate expression levels with therapy response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Chandan Sona, Yu-Te Yeh, Andreas Patsalos, Laszlo Halasz, Xin Yan, Natalia L. Kononenko, Laszlo Nagy, Matthew N. Poy
Summary: Through single-cell RNA sequencing analysis, this study found increased CADM1(+) cells adjacent to CD8(+) T cells in the islets of individuals with T1D and those who were autoantibody-positive, indicating that CADM1-mediated intercellular contact may facilitate the infiltration of cytotoxic T lymphocytes and could serve as a potential therapeutic target for preventing T1D pathogenesis.
Article
Immunology
Hye-Ran Kim, Jeong-Su Park, Yasmin Fatima, Maiza Kausar, Jin-Hwa Park, Chang-Duk Jun
Summary: The study reveals that the TM domain of IGSF4 can regulate TCR avidity, enhancing the antitumor activity of cytotoxic T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gene Kurosawa, Mariko Kondo, Yoshikazu Kurosawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Oncology
Aya Sugyo, Atsushi B. Tsuji, Hitomi Sudo, Fumiko Nomura, Hirokazu Satoh, Mitsuru Koizumi, Gene Kurosawa, Yoshikazu Kurosawa, Tsuneo Saga
Article
Gastroenterology & Hepatology
Winn Aung, Atsushi B. Tsuji, Hitomi Sudo, Aya Sugyo, Yoshinori Ukai, Katsushi Kouda, Yoshikazu Kurosawa, Takako Furukawa, Tsuneo Saga, Tatsuya Higashi
WORLD JOURNAL OF GASTROENTEROLOGY
(2017)
Article
Biochemistry & Molecular Biology
M. Sumitomo-Kondo, Y. Ukai, Y. Iba, N. Ohshima, K. Miura, A. Takasaki, Y. Kurosawa, G. Kurosawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Immunology
Daisuke Hirano, Nobuko Ohshima, Ritsuko Kubota-Koketsu, Ayami Yamasaki, Gene Kurosawa, Yoshinobu Okuno, Shunji Yoshida, Yoshikazu Kurosawa
JOURNAL OF IMMUNOLOGY RESEARCH
(2018)
Article
Biotechnology & Applied Microbiology
Narumi Uno, Tomohito Fujimoto, Shinya Komoto, Gene Kurosawa, Masaaki Sawa, Teruhiko Suzuki, Yasuhiro Kazuki, Mitsuo Oshimura
Article
Hematology
Shingo Nakahata, Syahrul Chilmi, Ayako Nakatake, Kuniyo Sakamoto, Maki Yoshihama, Ichiro Nishikata, Yoshinori Ukai, Tadashi Matsuura, Takuro Kameda, Kotaro Shide, Yoko Kubuki, Tomonori Hidaka, Akira Kitanaka, Akihiko Ito, Shigeki Takemoto, Nobuaki Nakano, Masumichi Saito, Masako Iwanaga, Yasuko Sagara, Kosuke Mochida, Masahiro Amano, Kouichi Maeda, Eisaburo Sueoka, Akihiko Okayama, Atae Utsunomiya, Kazuya Shimoda, Toshiki Watanabe, Kazuhiro Morishita
Summary: This study demonstrated that plasma sCADM1 concentrations gradually increased during disease progression from indolent to aggressive ATLL, and sCADM1 was identified as a specific biomarker for aggressive ATLL. sCADM1 is not only useful for monitoring response to chemotherapy and predicting relapse of ATLL, but also for distinguishing between ATLL and other inflammatory diseases such as HAM/TSP.
Article
Biochemistry & Molecular Biology
Hitomi Sudo, Atsushi B. Tsuji, Aya Sugyo, Gene Kurosawa, Yoshikazu Kurosawa, David Alexander, Hiroyuki Tsuda, Tsuneo Saga, Tatsuya Higashi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Nobuko Ohshima, Yoshitaka Iba, Ritsuko Kubota-Koketsu, Ayami Yamasaki, Keiko Majima, Gene Kurosawa, Daisuke Hirano, Shunji Yoshida, Mototaka Sugiura, Yoshizo Asano, Yoshinobu Okuno, Yoshikazu Kurosawa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Fukiko Hihara, Hiroki Matsumoto, Mitsuyoshi Yoshimoto, Takashi Masuko, Yuichi Endo, Chika Igarashi, Tomoko Tachibana, Mitsuhiro Shinada, Ming-Rong Zhang, Gene Kurosawa, Aya Sugyo, Atsushi B. Tsuji, Tatsuya Higashi, Hiroaki Kurihara, Makoto Ueno, Yukie Yoshii
Summary: This study developed a new in vitro tumor cell-binding assay system to select the highest-binding antibody for Cu-64-ipRIT treatment and predict therapeutic response. The findings demonstrated a correlation between in vitro cell binding and in vivo therapeutic efficacy, indicating the potential of Cu-64-TuBA for personalized Cu-64-ipRIT treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Oncology
Hitomi Sudo, Atsushi Tsuji, Aya Sugyo, Mitsuru Koizumi, Gene Kurosawa, Yoshikazu Kurosawa, Tsuneo Saga, Tatsuya Higashi
Article
Biochemistry & Molecular Biology
Aya Sugyo, Atsushi B. Tsuji, Hitomi Sudo, Mitsuru Koizumi, Yoshinori Ukai, Gene Kurosawa, Yoshikazu Kurosawa, Tsuneo Saga, Tatsuya Higashi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Shunsuke Shimosaki, Shingo Nakahata, Tomonaga Ichikawa, Akira Kitanaka, Takuro Kameda, Tomonori Hidaka, Yoko Kubuki, Gene Kurosawa, Lilin Zhang, Yukio Sudo, Kazuya Shimoda, Kazuhiro Morishita
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Gene Kurosawa, Mototaka Sugiura, Yoshinobu Hattori, Hiroyuki Tsuda, Yoshikazu Kurosawa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)