A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient

Sleep and circadian rhythm regulate circulating complement factors and immunoregulatory properties of C5a

(2011) Edimara S. Reis et al.   BRAIN BEHAVIOR AND IMMUNITY

Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors

(2011) C H Kim et al.   LEUKEMIA

A novel perspective on stem cell homing and mobilization: review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients

(2011) M Z Ratajczak et al.   LEUKEMIA

Innate immunity as orchestrator of stem cell mobilization

(2010) M Z Ratajczak et al.   LEUKEMIA

Novel insight into stem cell mobilization-Plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex

(2010) M Z Ratajczak et al.   LEUKEMIA

The endosteal ‘osteoblastic’ niche and its role in hematopoietic stem cell homing and mobilization

(2010) J-P Lévesque et al.   LEUKEMIA

How I treat paroxysmal nocturnal hemoglobinuria

(2009) R. A. Brodsky   BLOOD

Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes

(2009) H M Lee et al.   LEUKEMIA

How doPIG-Amutant paroxysmal nocturnal hemoglobinuria stem cells achieve clonal dominance?

(2009) Robert A Brodsky   Expert Review of Hematology

Altered lipid raft composition and defective cell death signal transduction in glycosylphosphatidylinositol anchor-deficient PIG-A mutant cells

(2008) Hadrian Szpurka et al.   BRITISH JOURNAL OF HAEMATOLOGY