Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders

Polycomb segment myeloid malignancies

(2012) Y. Saunthararajah et al.   BLOOD

Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes

(2012) F. Thol et al.   BLOOD

Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis

(2012) H. Makishima et al.   BLOOD

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A

(2011) A. M. Jankowska et al.   BLOOD

SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value

(2011) M. M. Patnaik et al.   BLOOD

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

(2011) L. Malcovati et al.   BLOOD

Plasma HHV8 DNA predicts relapse in individuals with HIV-associated multicentric Castleman disease

(2011) J. Stebbing et al.   BLOOD

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

(2011) D. Rossi et al.   BLOOD

Overexpression of MCM2 in myelodysplastic syndromes: Association with bone marrow cell apoptosis and peripheral cytopenia

(2011) Shiho Suzuki et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

(2011) Akira Yokoi et al.   FEBS Journal

Ring sideroblasts and sideroblastic anemias

(2011) M. Cazzola et al.   HAEMATOLOGICA

Sideroblastic anemia: molecular analysis of the ALAS2 gene in a series of 29 probands and functional studies of 10 missense mutations

(2011) Sarah Ducamp et al.   HUMAN MUTATION

SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts

(2011) V Visconte et al.   LEUKEMIA

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

(2011) Timothy A Graubert et al.   NATURE GENETICS

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

(2011) Víctor Quesada et al.   NATURE GENETICS

SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

(2011) E. Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

(2011) Lili Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic therapies for RNA mis-splicing diseases

(2011) Suzan M. Hammond et al.   TRENDS IN GENETICS

Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin

(2010) Valerie Edmond et al.   EMBO JOURNAL

Phosphorylation mechanism and structure of serine-arginine protein kinases

(2010) Gourisankar Ghosh et al.   FEBS Journal

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

(2010) C. J. David et al.   GENES & DEVELOPMENT

Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies

(2010) H Makishima et al.   LEUKEMIA

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial Iron Metabolism and Sideroblastic Anemia

(2009) Alex D. Sheftel et al.   ACTA HAEMATOLOGICA

Synthetic mRNA Splicing Modulator Compounds with in Vivo Antitumor Activity

(2009) Chandraiah Lagisetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells

(2009) B. J. Albert et al.   MOLECULAR CANCER THERAPEUTICS

Hematological manifestations of copper deficiency: a retrospective review

(2008) Thorvardur R. Halfdanarson et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Evolution of Spliceosomal snRNA Genes in Metazoan Animals

(2008) Manuela Marz et al.   JOURNAL OF MOLECULAR EVOLUTION