Article
Computer Science, Interdisciplinary Applications
Kevin Wright
Summary: This article investigates the confusion surrounding the definition and calculation of the Hopkins statistic, provides a protocol to guide its use, and offers a fast R function for accurate calculation.
Editorial Material
Immunology
Rama Dhenni, Tri Giang Phan
Summary: Lung-resident memory B cells can differentiate into localized effectors to prevent tissue reinfection, and may also include bystander cells generated by an alternative differentiation pathway, as shown by Gregoire et al. using lineage tracing.
TRENDS IN IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Michael H. Brill
Summary: The article discusses the definition problem of tristimulus values units and proposes a new defined equation to address existing issues.
COLOR RESEARCH AND APPLICATION
(2022)
Article
Engineering, Industrial
Joel G. Brawner, Gregory A. Harris, Gerard A. Davis
Summary: This paper provides a review of studies on safety and ergonomic outcomes in lean manufacturing environments over the past 40 years. The findings suggest that just-in-time production and 5S have unique contributions to these outcomes.
APPLIED ERGONOMICS
(2022)
Review
Biochemistry & Molecular Biology
Valentina Maria Cambuli, Marco Giorgio Baroni
Summary: This article provides a synthetic overview of research in the treatment of type 1 diabetes, focusing on the development of intelligent insulins and the use of artificial intelligence in automated insulin therapy. It outlines the latest developments in the search for intelligent insulins and the promising advances in the use of artificial intelligence for glucose control. The future of insulin treatment in type 1 diabetes appears promising with the potential for a closed-loop artificial pancreas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
William S. Blaner, Igor O. Shmarakov, Maret G. Traber
Summary: This review focuses on the mechanisms of action of vitamin A and vitamin E in the body, suggesting that vitamin A acts as an indirect antioxidant by transcriptionally regulating genes involved in antioxidant responses, while vitamin E functions as a direct antioxidant and helps prevent the increase of peroxidized lipids that affect metabolic pathways and gene expression profiles. The review also discusses the lack of compelling evidence for a direct transcriptional mechanism of vitamin E similar to that of vitamin A.
ANNUAL REVIEW OF NUTRITION, VOL 41, 2021
(2021)
Article
Chemistry, Applied
Hugh S. Fairman
Summary: There is a common misunderstanding among colorists regarding the units involved in the tristimulus integration equation. This note examines the development of these units using the 1931 RGB experiment as an example and concludes that they are consistent.
COLOR RESEARCH AND APPLICATION
(2023)
Article
Oncology
Salem Alshemmari, Mazyad Almazyad, Aisha Alwehaib, Reem Ameen
Summary: The study investigated the epidemiology of Ph-negative MPNs among Kuwaiti nationals, revealing ET as the most common subtype and JAK2V617F as the most common driver mutation. A significant percentage of patients (19.2%) presented with thrombosis at diagnosis, with males more likely to have arterial thrombosis and females more likely to have venous thrombosis.
Article
Psychology, Clinical
Marcus Mund, Marlies Maes, Pia M. Drewke, Antonia Gutzeit, Isabel Jaki, Pamela Qualter
Summary: This article investigates the psychometric features of various loneliness measures and finds that the scores of these measures are reliable and valid. The study also explores the correlations between loneliness scores and demographic factors, personality traits, satisfaction, and network characteristics.
Article
Sport Sciences
Niels Mertens, Filip Boen, Niklas K. Steffens, S. Alexander Haslam, Katrien Fransen
Summary: The study found that leadership structures in sports teams can change significantly over the course of a competitive season, with transitions to more shared forms of leadership attributed to the emergence of informal leaders over time. These changes were found to benefit team functioning and performance as teams evolve towards shared leadership.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2021)
Article
Biochemistry & Molecular Biology
Ctibor Skuta, Christopher Southan, Petr Bartunek
Summary: The NIH Molecular Libraries Program started identifying small-molecule chemical probes in 2005, inspiring similar efforts from other organizations since 2010. By standardizing, integrating, and comparing probe compounds from 12 sources, challenges and unexpected anomalies were revealed. A total of 548 high-quality chemical probes covering 447 distinct protein targets were developed and added to the Probes & Drugs portal, with plans for regular updates as new data sources emerge.
RSC MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Erika Morsia, Elena Torre, Antonella Poloni, Attilio Olivieri, Serena Rupoli
Summary: Despite their differences in clinical presentation, myeloproliferative neoplasms (MPN) share similarities in morphology, propensity for thrombotic events and leukemia transformation, and a complex molecular pathogenesis. Key driver mutations, such as JAK2, MPL, and CALR, activate the JAK-STAT signaling pathway, which is characteristic of MPN pathogenesis. Recent research has revealed the presence of co-occurring somatic mutations associated with epigenetic regulation, mRNA splicing, transcriptional mechanisms, signal transduction, and DNA repair mechanisms in MPN patients. Integrating genetic information into clinical practice has already improved disease monitoring and provided prognostic information regarding disease progression. While current therapeutic approaches have limited disease-modifying activity, a deeper understanding of the genetic basis of MPN has identified potential targets for targeted therapies. This review aims to explore the molecular landscape of MPN, providing a comprehensive overview of driver mutations, additional mutations, their impact on pathogenesis, prognostic value, and future implications for therapeutic management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Political Science
Nikolay Marinov, Maria Popova
Summary: The rise of conspiracy theories in Eastern European democracies exacerbates the issue of state capture and makes it difficult for voters to differentiate between true political conspiracies and baseless theories. More research on the conspiracy cleavage is needed to understand the nature of democratic backsliding in Eastern Europe.
PERSPECTIVES ON POLITICS
(2022)
Article
Communication
Ronald F. Chau, Widyasita N. Sawyer, Jeff Greenberg, Matthias R. Mehl, David A. Sbarra
Summary: Self-compassion is significantly correlated with well-being, with observed self-compassion showing a stronger association with reduced distress compared to self-rated compassion. Observers use certain cues to perceive self-compassion in others, highlighting the importance of behavioral manifestations of affect in shaping ratings.
JOURNAL OF SOCIAL AND PERSONAL RELATIONSHIPS
(2022)
Article
Pathology
David M. Ross, Candice Thomson, Nada Hamad, Steven W. Lane, Kate Manos, Andrew P. Grigg, Belinda Guo, Wendy N. Erber, Ashleigh Scott, Nick Viiala, Lynette Chee, Maya Latimer, Courtney Tate, Carolyn Grove, Andrew C. Perkins, Piers Blombery
Summary: Myeloproliferative neoplasms are characterized by somatic mutations in pathways regulating cell proliferation, epigenetic modifications, RNA splicing, or DNA repair. Assessment of mutational profile aids in diagnosis, classification, prognosis evaluation, and guiding targeted therapy. Massively parallel sequencing, especially disease-specific next generation sequencing panels, is the most effective way to provide information on various genetic variants.
