期刊
LEUKEMIA
卷 23, 期 5, 页码 856-862出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2008.372
关键词
microRNA; APL; ATRA; PU.1; IRF-1; IRF-9
资金
- AIRC
- European Union [LSHB-CT-2004 005276]
- SIROCCO [LSHG-CT-2006-037900]
- Centro di eccellenza BEMM
In the acute promyelocytic leukemia (APL) bearing the t(15; 17), all-trans-retinoic acid (ATRA) treatment induces granulocytic maturation and complete remission of leukemia. We identified miR-342 as one of the microRNAs (miRNAs) upregulated by ATRA during APL differentiation. This miRNA emerged as a direct transcriptional target of the critical hematopoietic transcription factors PU.1 and interferon regulatory factor (IRF)-1 and IRF-9. IRF-1 maintains miR-342 at low levels, whereas the binding of PU.1 and IRF-9 in the promoter region following retinoic ATRA-mediated differentiation, upregulates miR-342 expression. Moreover, we showed that enforced expression of miR-342 in APL cells stimulated ATRA-induced differentiation. These data identified miR-342 as a new player in the granulocytic differentiation program activated by ATRA in APL. Leukemia (2009) 23, 856-862; doi:10.1038/leu.2008.372; published online 8 January 2009
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