Article
Biotechnology & Applied Microbiology
Ke-Fan Wang, Jing An, Zhen Wei, Can Cui, Xiang-Hua Ma, Chao Ma, Han-Qiu Bao
Summary: In this paper, a novel imbalance classification method based on deep learning and fuzzy support vector machine, named DFSVM, is proposed. The method utilizes a deep neural network to obtain an embedding representation of the data and performs oversampling in the embedding space to address the data imbalance issue. Furthermore, a fuzzy support vector machine is used as the final classifier to improve the classification quality of minority classes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemical Research Methods
Heba El-Behery, Abdel-Fattah Attia, Nawal El-Fishawy, Hanaa Torkey
Summary: Our paper proposes a new scheme for predicting drug-target interactions based on drug chemical structures and protein sequences. It utilizes drug fingerprints, drug descriptors, protein composition, and dipeptide composition to extract characteristics. The imbalanced data problem is addressed by developing an approach for extracting negative samples using a support vector machine one-class classifier. The proposed method outperforms existing techniques in terms of prediction accuracy and other evaluation metrics.
JOURNAL OF BIOLOGICAL ENGINEERING
(2022)
Article
Computer Science, Information Systems
Arjun Puri, Manoj Kumar Gupta, Kanica Sachdev
Summary: This article proposes a model for studying drug-target interaction problems using computational techniques. The model uses feature representations and resampling techniques to handle class imbalance, and utilizes a soft voting ensemble method to improve prediction accuracy. Experiments demonstrate that the proposed model outperforms existing models on standard datasets.
MULTIMEDIA TOOLS AND APPLICATIONS
(2022)
Article
Thermodynamics
Tiago de Oliveira Nogueira, Gilderlanio Barbosa Alves Palacio, Fabricio Damasceno Braga, Pedro Paulo Nunes Maia, Elineudo Pinho de Moura, Carla Freitas de Andrade, Paulo Alexandre Costa Rocha
Summary: This study combines DFA with SVM and RBFK methods for imbalance level classification in wind turbines, with RBFK showing excellent performance in different rotation speeds.
Article
Computer Science, Artificial Intelligence
Barenya Bikash Hazarika, Deepak Gupta
Summary: This paper introduces a new support vector machine (SVM) model and an improved least squares SVM model to address class imbalance learning (CIL) in binary classification problems. The algorithms assign weights to samples based on their class distributions during training to reduce the effects of CIL.
NEURAL COMPUTING & APPLICATIONS
(2021)
Article
Mathematical & Computational Biology
Sofia D'Souza, K. V. Prema, S. Balaji, Ronak Shah
Summary: Chemogenomics, or proteochemometrics, uses computational methods to predict drug-target interactions based on large-scale data. This study develops a deep learning CNN model using one-dimensional SMILES for drugs and protein binding pocket sequences as inputs to predict unknown ligand-target interactions. The proposed method outperforms shallow machine learning methods in terms of prediction accuracy and computational efficiency.
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES
(2023)
Article
Biochemical Research Methods
Qing Ye, Xiaolong Zhang, Xiaoli Lin
Summary: This paper proposes a drug-target interaction prediction method based on multiple classification strategies (MCSDTI), which improves the effectiveness of prediction by using different classification strategies for targets with smaller and larger numbers of interactions.
BMC BIOINFORMATICS
(2022)
Article
Computer Science, Information Systems
Salim Rezvani, Xizhao Wang
Summary: The study introduces a class imbalance learning method using Fuzzy ART and IFTSVM, which effectively addresses classification issues related to class imbalance, noise, outliers, and large-scale datasets.
INFORMATION SCIENCES
(2021)
Article
Computer Science, Artificial Intelligence
Kai Qi, Hu Yang
Summary: In this paper, we propose a novel robust geometric twin parametric-margin support vector machine (RGTPSVM) to tackle the challenge of outliers in real data. By constructing a classifier based on two nonparallel boundary hyperplanes obtained through solving a quadratic programming problem, and using a rescaled squared hinge loss function, RGTPSVM achieves better resilience against outliers and improves prediction accuracy.
NEURAL COMPUTING & APPLICATIONS
(2023)
Article
Medicine, Research & Experimental
Reiko Watanabe, Toshio Kawata, Shinya Ueda, Takumi Shinbo, Mitsuo Higashimori, Yayoi Natsume-Kitatani, Kenji Mizuguchi
Summary: This study aimed to construct machine learning models for predicting in vivo clearance contribution ratio using chemical structure information alone. The results showed that using structural information alone can provide in vivo values comparable to in vitro experimental values, with higher accuracy for compounds involved in CYP induction or inhibition. This new approach to predicting in vivo clearance contribution ratio in the early stages of drug discovery can improve the efficiency of the drug optimization process.
MOLECULAR PHARMACEUTICS
(2023)
Article
Computer Science, Information Systems
Saiji Fu, Xiaotong Yu, Yingjie Tian
Summary: v-CSSVM is a novel cost sensitive learning model that combines the advantages of v-SVM and the LINEX loss function, showing competitive performance in imbalanced classification.
INFORMATION PROCESSING & MANAGEMENT
(2022)
Article
Green & Sustainable Science & Technology
G. R. Hubner, H. Pinheiro, C. E. de Souza, C. M. Franchi, L. D. da Rosa, J. P. Dias
Summary: Condition monitoring systems are crucial for cost reduction in the wind energy sector. This paper proposes a method based on Support Vector Machine to detect rotor mass imbalance, using estimated speed and electrical quantities as input variables, and aiming to obtain the magnitude and angular position of the imbalance. Statistical tools are employed to estimate intermediate classes, improving detection accuracy.
Article
Computer Science, Information Systems
Zichen Zhang, Shifei Ding, Yuting Sun
Summary: This paper introduces a new method called multiple birth support vector regression (MBSVR), which constructs the regressor from multiple hyperplanes obtained by solving small quadratic programming problems, aiming for faster computation and better fitting precision.
INFORMATION SCIENCES
(2021)
Article
Biochemical Research Methods
Qi An, Liang Yu
Summary: This study introduces a new method for predicting drug-target interactions in multiplex networks and achieves accurate results that outperform existing algorithms. Additionally, a reasonable model is proposed to address the widespread negative sampling problem, offering new insights for future research.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Computer Science, Artificial Intelligence
M. A. Ganaie, M. Tanveer, Alzheimer's Disease Neuroimaging Initiative
Summary: This paper introduces a novel fuzzy least squares projection twin support vector machines for class imbalance learning, which outperforms baseline models in experiments.
APPLIED SOFT COMPUTING
(2021)