Review
Chemistry, Physical
Rui A. Goncalves, Krister Holmberg, Bjorn Lindman
Summary: This paper provides an overview of the self-assembly, intermolecular interactions, and properties of cationic surfactants, as well as their interactions with other solutes and surfaces. It also discusses the versatile properties of single-chain and double-chain cationic surfactants, as well as other special cationic surfactants, and their relationship with skin toxicity and environmental factors. Furthermore, the paper explores the mixing effects of cationic surfactants with other surfactants, polymers, proteins, and DNA, and outlines established and emerging applications of cationic surfactants.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Polymer Science
Tea Kaurin, Tanja Pusic, Mirjana Curlin
Summary: This research focuses on functionalizing a standard polyester fabric with biopolymer chitosan, using alkaline hydrolysis with the addition of cationic and anionic surfactants as promoters. The study compares the compatibility of chitosan with untreated and alkali-hydrolyzed fabrics through the analysis of mechanical and physico-chemical properties. The results show that alkaline hydrolysis of polyester fabric has the best potential for functionalization with chitosan, and the addition of surfactants as promoters is not necessary in the pretreatment process phase.
Article
Polymer Science
Thu Thao Pham, Shin-ichi Yusa
Summary: Poly(4-((3-methacrylamidopropyl)dimethylammonium)butane-1-sulfonate) (PSBP) exhibited upper critical solution temperature (UCST) behavior in aqueous solutions, which could be controlled by adjusting the polymer and NaCl concentrations. PSBP formed a water-soluble ion complex with cetyltrimethylammonium bromide (CTAB) via attractive electrostatic interaction. The stoichiometrically neutral-charge PSBP/CTAB complex exhibited UCST behavior in aqueous solutions.
Article
Engineering, Environmental
Yan Bao, Lu Gao, Feitong Wang, Jianzhong Ma
Summary: Gemini surfactants are in high demand globally for their potential applications in paper, medical hygiene, and textile industries. This study focuses on the design and synthesis of Gemini surfactants integrated with biosafety and multi-functionality for environmental protection and cost-effective industrial processes. The effects of three heterocyclic cationic Gemini surfactants with different hydrophilic groups on antibacterial, dispersion, and fixation properties in leather processing are investigated.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)
Article
Chemistry, Physical
Zoya Zaheer, Samia A. Kosa, Mohammad Osama, Mohd Akram
Summary: The study investigated the binding capabilities of flurbiprofen drug with a new type of gemini surfactant using spectroscopic methods, revealing significant interaction and a correlation with the chain length and critical micellar concentration of the surfactant.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Javed Masood Khan, Ajamaluddin Malik, Sundus Mohammed Alresaini
Summary: Protein aggregation and amyloid fibrillation are associated with neurodegenerative disorders. This study investigated the effects of CTAB on the aggregation process of insulin at pH 7.4 and 2.0. The results showed that low concentrations of CTAB induced insulin aggregation at pH 7.4, but higher concentrations did not. However, at pH 2.0, both low and high concentrations of CTAB were unable to promote insulin aggregation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Analytical
Laure Wiest, Barbara Giroud, Azziz Assoumani, Francois Lestremau, Emmanuelle Vulliet
Summary: A multi-family analytical strategy for quantifying surfactants in surface waters was developed, optimized, and validated, with the method suitable for monitoring low concentrations of surfactants. Anionic, cationic, and non-ionic surfactants were detected in French river water samples, with median concentrations ranging from 24 ng/L to 4.6 μg/L.
Article
Nanoscience & Nanotechnology
Timothy H. Cheung, Chang Xue, Daniel A. Kurtz, Molly S. Shoichet
Summary: Traditionally, therapeutic release from hydrogels is controlled by encapsulation within nanoparticles, but this approach is limited for the release of proteins. To address this issue, a new encapsulation-free release platform was designed where negatively charged proteins are adsorbed to the exterior of transiently cationic nanoparticles. This strategy offers a promising new method for controlled release of anionic protein therapeutics.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Xin-Ning Bao, Wei-Dong Zhang, Hong-Ze Gang, Shi-Zhong Yang, Ying-Cheng Li, Bo-Zhong Mu
Summary: A novel binary system consisting of a cationic surfactant and a counter ion that can form wormlike micelles with high viscosity is proposed. The experimental results show the formation of long elongated wormlike micelles in dilute solution at temperatures exceeding 60 degrees Celsius.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Biochemistry & Molecular Biology
Quentin Barnes, Claire Longuet, Francois Ganachaud
Summary: This study presents preliminary results on cationic ring-opening polymerization of hexamethylcyclotrisiloxane (D-3) in water, with a focus on experiments conducted using tris(pentafluorophenyl)borane (BCF) as the catalyst. By using different catalysts and surfactants, polymers of various molar masses can be prepared in a straightforward manner. The presence or absence of surfactants influences the size and stability of the emulsions generated during the reaction process, with a tentative mechanism proposed for the observed phenomena.
Article
Engineering, Chemical
Priyabrata Pal, Aiza Gay Corpuz, Shadi W. Hasan, Mika Sillanpaa, Fawzi Banat
Summary: This study successfully demonstrated the removal of single and mixed dyes from aqueous solutions using CGA flotation with a natural surfactant, showing high removal efficiency and the potential for recycling the materials.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zakaria Hafidi, Mohammed El Achouri, Francisco F. O. Sousa, Lourdes Perez
Summary: The study demonstrates that amino-alcohols based cationic surfactants exhibit good antifungal activity against different Candida strains, with minimum inhibitory concentrations ranging from 0.002 to 0.30 mM. The antifungal activity increased with the hydrophobicity of the inhibitors in the majority of Candida strains tested during the evaluation process.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Physical
Trang Vu, Peter Koenig, Mike Weaver, Howard D. Hutton, Gerald B. Kasting
Summary: The study focused on the thickening properties of sulfate-free and amino acid-based surfactant systems, revealing mechanisms behind the differences in thickening response compared to traditional sulfate-based formulations. Through experimental analysis of various thickeners, including cationic surfactants and inorganic counterions, insights were gained into the viscoelastic properties and dynamics of micelles in these systems, shedding light on the reasons for their differing thickening behaviors.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Energy & Fuels
Hala T. Handal, Walied A. A. Mohamed, Ammar A. Labib, Samia A. Moustafa, Alaa A. Sery
Summary: In this study, surface-functionalized mesoporous NiO nanoparticles were successfully synthesized using a facile one-pot precipitation method, with different bases affecting the surface modification and formation mechanism of NiO. The surface functionalization was found to significantly impact the electronic, optical, and magnetic properties of NiO, providing new perspectives for various applications.
JOURNAL OF ENERGY STORAGE
(2021)
Article
Environmental Sciences
Mamoun Fellah, Naouel Hezil, Kamel Guerfi, Ridha Djellabi, Alex Montagne, Alain Iost, Kirill Borodin, Aleksei Obrosov
Summary: The study found that anionic surfactant showed better adsorption on kaolinite compared to cationic surfactant; the adsorption kinetics fit the pseudo-second-order model well; BDDAB adsorption tended to follow Langmuir-Freundlich and Freundlich isotherm models, while SDS adsorption adhered only to the Langmuir-Freundlich model.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Milan Jokanovic, Patrik Oleksak, Kamil Kuca
Summary: This article examines the potential link between organophosphorus (OP) pesticides and neurological disorders, including dementia, attention deficit hyperactivity disorder, neurodevelopment, autism, cognitive development, Parkinson's disease, and chronic organophosphate-induced neuropsychiatric disorder. These effects are primarily observed after chronic exposure to low doses of OP pesticides. The article also discusses three well-defined neurotoxic effects in humans resulting from single doses of OP compounds. These effects include the cholinergic syndrome, the intermediate syndrome, and organophosphate-induced delayed polyneuropathy. Poisoning can generally be prevented through improved administrative control, restricted access to OP pesticides, effective personal protection measures, and education for OP pesticide applicators and medical staff.
Review
Toxicology
Ying Deng, Vojtech Adam, Eugenie Nepovimova, Zbynek Heger, Marian Valko, Qinghua Wu, Wei Wei, Kamil Kuca
Summary: Cellular senescence leads to reduced tissue regeneration and increased inflammation, and is associated with diseases like diabetes, neurodegenerative diseases, and tumorigenesis. The signaling pathway c-Jun N-terminal kinase (JNK) is involved in the regulation of cellular senescence. JNK can accelerate hypoxia-induced neuronal cell senescence by downregulating hypoxia inducible factor-1 alpha. It can also promote cellular senescence by inhibiting mTOR activity and triggering autophagy.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Martin Valis, Alzbeta Dlabkova, Jakub Hort, Francesco Angelucci, Jaroslav Pejchal, Kamil Kuca, Zbysek Pavelek, Jana Zdarova Karasova, Michal Novotny
Summary: This study examined the differences in plasma and cerebrospinal fluid (CSF) levels of donepezil among Alzheimer's disease patients receiving a standard dose of 10 mg/day. The results showed that the CSF/plasma donepezil concentration ratio increased significantly in the 24 h group compared to the 6 h and 12 h groups. This finding suggests that measuring the CSF/plasma donepezil concentration ratio could help determine the optimal dose of donepezil.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Ying-Ning Zou, Qiu-Yun Qin, Wen-Ya Ma, Li-Jun Zhou, Qiang-Sheng Wu, Yong-Jie Xu, Kamil Kuca, Abeer Hashem, Al-Bandari Fahad Al-Arjani, Khalid F. Almutairi, Elsayed Fathi Abd-Allah
Summary: Metabolomic analysis revealed the metabolic mechanisms of mycorrhiza-enhanced drought tolerance in walnuts. The results showed that AMF inoculation increased biomass production and leaf water potential in walnut under drought stress, accompanied by regulation of numerous metabolic pathways. Furthermore, the regulation of walnut metabolites by AMF exhibited differences under different stress conditions.
Article
Biochemistry & Molecular Biology
Somesh Kumar, Neha Choudhary, Mohammed Faruq, Arun Kumar, Ravindra K. Saran, Prem Kumar Indercanti, Vikram Singh, Haseena Sait, Sunita Jaitley, Martin Valis, Kamil Kuca, Sunil K. Polipalli, Manoj Kumar, Tejveer Singh, Prashanth Suravajhala, Rohit Sharma, Seema Kapoor
Summary: The mitochondrial permeability transition pore (mtPTP) is essential for altering mitochondria's structure and function. Cyclophilin D (CypD), a mitochondrial protein, plays a role in regulating mtPTP function, making it a potential target for mitochondrial therapeutic studies. This study explored the impact of anastrozole on mtPTP functioning using docking, molecular dynamics, and network-guided studies. The results showed that anastrozole outperformed cyclosporine in inhibiting mtPTP, inducing membrane depolarization, reducing mitochondrial swelling and superoxide generation, and increasing ATP levels. These findings suggest that anastrozole could serve as a therapeutic agent for mitochondrial disorders by regulating mtPTP activity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Yihao Li, Haoyu Gao, Eugenie Nepovimova, Qinghua Wu, Vojtech Adam, Kamil Kuca
Summary: Recombinant ferritins play a crucial role in maintaining iron homeostasis in living organisms. They have found wide application in multimodal nanomedicine, particularly in anticancer treatment and vaccination. The fusion of viral proteins and ferritin subunits in recombinant particles has been shown to enhance the immune response and antibody production. Targeted ferritin nanoparticles can specifically deliver drugs to tumor tissue, while ferritin linked with contrast agents or fluorescent dyes has potential use in cancer theranostics. This review provides a comprehensive summary of the utilization of recombinant ferritins in multimodal nanomedicine, with emphasis on their role as nanovaccines, nanozymes, and targeted therapy carriers for bioimaging.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Zainab Abdullah, Muhammad Umer Ashraf, Kashif Barkat, Syed Faisal Badshah, Umaira Rehman, Asma Razzaq, Asif Mahmood, Farid Ulhaq, Hitesh Chopra, Summya Rashid, Marian Valko, Suliman Alomar, Kamil Kuca, Rohit Sharma
Summary: The aim of this study was to develop a controlled delivery system for Tramadol HCl (TRD), an opioid analgesic used for moderate to severe pain. A pH-responsive hydrogel network was formulated using natural polymers, aloe vera gel and tamarind gum, monomer and crosslinker. The hydrogels showed pH sensitivity and exhibited a maximum release of 92.22% of TRD over 24 hours at pH 7.4.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Ci Deng, Ying-Ning Zou, Abeer Hashem, Kamil Kuca, Elsayed Fathi Abd-Allah, Qiang-Sheng Wu
Summary: This study visually analyzed the literature on GRSP in the C field from 1999 to 2022 using CiteSpace software and the core collection of Web of Science. The study found that research on GRSP in the C field could be divided into an initial stage, a steady stage, and an explosive stage. The Chinese Academy of Sciences had the most publications, and the United States, China, and India were the leading nations in the C field of GRSP.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2023)
Review
Medicine, Research & Experimental
Harsh Kumar, Rajni Dhalaria, Shivani Guleria, Richard Cimler, Ruchi Sharma, Shahida Anusha Siddiqui, Marian Valko, Eugenie Nepovimova, Daljeet Singh Dhanjal, Reena Singh, Vijay Kumar, Ashok Kumar Pathera, Narinder Verma, Talwinder Kaur, Sivakumar Manickam, Suliman Y. Alomar, Kamil Kuca
Summary: Cells produce reactive oxygen species (ROS) as a metabolic by-product, and hydrogen peroxide (H2O2) is an important ROS entity that plays a crucial role in physiological processes. However, excessive production of H2O2 can lead to inflammatory responses and health complications. This review focuses on understanding the formation of H2O2, its impact on human health, and the potential of plant extracts and Lactobacillus sp. in alleviating H2O2-induced oxidative stress.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Daniel A. S. Kitagawa, Marcelo C. dos Santos, Kamil Kuca, Tanos C. C. Franca, Samir F. de A. Cavalcante
Summary: This study compared the toxicity of representatives from the V and A series nerve agents through in vitro experiments, and found similar inhibition potency between both agents.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Tanos Celmar Costa Franca, Jorge Alberto Valle da Silva, Marcelo Carneiro dos Santos, Samir Frontino de Almeida Cavalcante, Kamil Kuca
Summary: The Near Attack Conformation (NAC) approach emphasizes the importance of optimal conditions for substrate atom organization and positioning in enzyme-catalyzed reactions. This approach has been successfully applied to investigate the reactivation mechanism of acetylcholinesterase inhibited by nerve agents, providing a better understanding of this mechanism and consistent corroboration with experimental data. This article summarizes the achievements so far and outlines future perspectives.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Agriculture, Multidisciplinary
Ying Deng, Li You, Xu Wang, Wenda Wu, Kamil Kuca, Qinghua Wu, Wei Wei
Summary: Deoxynivalenol (DON) is a common mycotoxin contaminant in food and feed, posing toxic effects on humans and animals. Various mechanisms, such as oxidative stress, MAPK signaling pathway, hypoxia-inducible factor-1 alpha, noncoding RNA, and signaling pathways including Wnt/beta-catenin, FOXO, and TLR4/NF-kappa B, contribute to DON toxicity. The intestinal microbiota and brain-gut axis also play a crucial role in DON-induced growth inhibition. Detection, biological control, and enzyme degradation of mycotoxins are the current and future research priorities.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Xueqin Huang, Li You, Eugenie Nepovimova, Miroslav Psotka, David Malinak, Marian Valko, Ladislav Sivak, Jan Korabecny, Zbynek Heger, Vojtech Adam, Qinghua Wu, Kamil Kuca
Summary: Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are important kinases in cell growth and DNA damage repair, and their dysfunction and aberrant activation are linked to various diseases including cancer. Inhibitors targeting the PI3K/AKT/mTOR pathway and PIKK inhibitors related to DNA damage response have shown promise in cancer treatment. However, combination therapies are needed to overcome drug resistance and improve efficacy.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Klaudia Jomova, Marcel Cvik, Peter Lauro, Marian Valko, Erik Cizmar, Suliman Y. Alomar, Saleh H. Alwasel, Patrik Oleksak, Zofia Chrienova, Eugenie Nepovimova, Kamil Kuca, Christopher J. Rhodes
Summary: The antioxidant properties of flavonoids with hydroxyl groups allow them to chelate redox active metals and scavenge free radicals. This paper studies the antioxidant and prooxidant properties of baicalein and its complexes with Cu(II) under different conditions. The results show that baicalein and Cu(II)-baicalein complexes have moderate ROS scavenging efficiency and can protect DNA from damage caused by ROS. These findings suggest that baicalein could be a therapeutic agent for diseases involving disrupted metabolism of copper, while low concentrations of baicalein may not inhibit the pro-oxidant effect of copper ions and ascorbate in cancer cells, leading to effective DNA damage.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Immunology
Aetsam Bin Masood, Sajida Batool, Sajid Nazir Bhatti, Asad Ali, Marian Valko, Klaudia Jomova, Kamil Kuca
Summary: This study quantified the plasma levels of PD-L1 as a biomarker for the clinical management of GBM and found that PD-L1 levels were significantly higher in GBM, which was associated with poor survival.
FRONTIERS IN IMMUNOLOGY
(2023)
