期刊
LETTERS IN DRUG DESIGN & DISCOVERY
卷 6, 期 8, 页码 563-567出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157018009789353419
关键词
Huperzine A; VX; Russian VX; Brain; Nerve agent; Acetylcholinesterase; Pretreatment
资金
- project of Ministry of Defence (Czech Republic) [FVZ0000604]
Organophosphate nerve agents are still considered as potential threats in both military and terrorism situations. They are potent irreversible inhibitors of acetylcholinesterase in central and also in peripheral compartment. Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for human use or is in course of clinical trials for the treatment of Alzheimer's disease. This compound has also been successfully tested for pretreatment of organophosphate poisoning. In this study Hup A was tested as a prophylaxis against two V-nerve agents (VX and Russian VX). According to the obtained results, Hup A was able to partially protect AChE in the blood, diaphragm and brain against inhibition caused by Russian VX and VX.
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