Article
Chemistry, Physical
Jakob G. Hjorringgaard, Arne Miller, Claus E. Andersen, Dominique Cloetta, Willi Wandfluh, Alan Tallentire
Summary: In this study, the radiation response of Bacillus pumilus spores exposed to different radiation qualities was investigated, and it was found that the radiation resistance of the spores is independent of beam quality.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Engineering, Biomedical
Sebastian Hoefel, Michael Stehle, Felix Zwicker, Michael K. Fix, Malte Drescher
Summary: In EPR dosimetry, uncertainty analysis was conducted for doses ranging from 1 to 70 Gy using AL and LFM pellets. LFM pellets demonstrated lower dose uncertainties compared to AL pellets, making them more suitable for applications in radiotherapy.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Chemistry, Physical
Mantvydas Merkis, Egidijus Griskonis, Jurgita Laurikaitiene, Judita Puiso, Ignas Pikas, Satimboy Palvanov, Diana Adliene
Summary: This study investigates the dose sensitivity enhancing effect of silver nanoparticles on dosimetric gels. The nanoparticles are added to nMAG and NIPAM dose gel formulations, and their synthesis and characterization are conducted. The results show that Ag nanoparticles allow for higher sensitivity in both NIPAM and nMAG dose gels, and further analysis indicates signs of radiation-enhancing effect. Improved gel dosimeters could be valuable for dose verification procedures, although the application of nanoparticle-enriched dose gels for simulating dose enhancement effect in human tissue is not straightforward due to variations in different gel dosimeters.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Public, Environmental & Occupational Health
Martin Bucher, Tina Weiss, David Endesfelder, Francois Trompier, Yoann Ristic, Patrizia Kunert, Helmut Schlattl, Augusto Giussani, Ursula Oestreicher
Summary: In this study, variations and pitfalls associated with the experimental setups used to establish calibration curves in biological dosimetry with X-ray cabinets were investigated. The orientation of the sample tubes had a significant effect on the radiation dose, with a larger dose gradient observed in vertically oriented tubes. The addition of an extra fan heater did not consistently impact the dose.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin P. Martinov, Elizabeth M. Fletcher, Rowan M. Thomson
Summary: This study investigates the dose-enhancement effect of gold nanoparticles in radiotherapy using Monte Carlo simulations. The results show that the arrangement of gold nanoparticles, gold concentration, and photon energy significantly affect the dose enhancement factors at the nucleus and cytoplasm levels.
Article
Chemistry, Analytical
Zahra Alyani Nezhad, Ghazale Geraily, Wrya Parwaie, Elham Hossein Nezhad
Summary: This study evaluated the dose enhancement factor (DEF) of bismuth oxide nanoparticles using different gel dosimeters. The results showed that DEF decreased when nanoparticles were combined with the gel. Therefore, the characteristics of nanoparticles and the components of the gel can significantly affect the feasibility of using a gel dosimeter to evaluate DEF.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin P. P. Martinov, Elizabeth M. M. Fletcher, Rowan M. M. Thomson
Summary: This study used multiscale Monte Carlo simulations to evaluate variations in cytoplasm and nucleus dose enhancement factors over tumor volumes. The results showed that cell/nucleus size, gold particle distribution, gold concentration, and cell position in the tumor all had significant effects on the dose. This highlights the importance of choosing the proper computational model and accounting for intrinsic variations in cell/nucleus size and gold concentration when simulating gold nanoparticle dose-enhanced radiation therapy.
Article
Chemistry, Multidisciplinary
Ngoc Han Huynh, James C. L. Chow
Summary: This study investigated the effectiveness of cancer cell killing by gold nanoparticles in proton radiation, showing that the dose enhancement ratio increases with smaller nanoparticle size, shorter distance to DNA, and lower proton beam energy. The maximum dose enhancement ratio (1.83) was achieved with a 25 nm-radius gold nanoparticle, irradiated by a 0.5 MeV proton beam and located 30 nm away from the DNA.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Biomedical
Iara S. Lima, Eder J. Guidelli, Oswaldo Baffa
Summary: Gold nanoparticles are extensively used to enhance the sensitivity of radiation dosimeters. Nanocomposites of alanine, 2-methylalanine, asparagine and monosodium glutamate containing gold nanoparticles were prepared and characterized. The dosimetric response of the nanocomposite dosimeters is influenced by factors such as radiation dose, gold mass percentage, and intrinsic sensitivity of the materials. Higher DEFs were observed for materials with lower intrinsic sensitivities and lower radiation doses. These results provide new insights into the use of gold nanoparticles for constructing more sensitive radiation dosimeters.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Environmental Sciences
Barbara Michalec, Cinzia De Angelis, Gabriela Foltynska, Tomasz Horwacik, Brigitte Reniers, Agnieszka Wochnik, Renata Kopec, Jan Swakon
Summary: Quality control of therapeutic photon beams is widely used in photon radiotherapy, while there is no standardized dosimetry audit program for proton centers in Europe. This study evaluated the applicability of alanine/EPR dosimetry systems developed at different institutions for routine mailed dose audits of passively scattered therapeutic proton beams. The evaluation demonstrated good agreement between the measured dose by three laboratories and the delivered dose determined with an ionization chamber. The properties of alanine, such as non-destructive readout, tissue equivalence, weak energy dependence, dose rate independence, and insignificant fading, make it a suitable candidate for dosimetry in postal auditing in proton ocular radiotherapy.
RADIATION PROTECTION DOSIMETRY
(2023)
Article
Oncology
Elena Vlastou, Evaggelos Pantelis, Efstathios P. Efstathopoulos, Pantelis Karaiskos, Vasileios Kouloulias, Kalliopi Platoni
Summary: This study investigates the dose enhancement effect of gold nanoparticles (AuNPs) under different irradiation conditions. The results suggest that a significant dose increase can be achieved, especially at close distances to AuNPs.
Article
Radiology, Nuclear Medicine & Medical Imaging
M. De Saint -Hubert, C. De Angelis, Z. Knezevic, B. Michalec, B. Reniers, E. Pyszka, L. Stolarczyk, J. Swakon, G. Foltynska, A. Wochnik, A. Parisi, M. Majer, R. M. Harrison, R. Kopec, F. Vanhavere, P. Olko
Summary: The lack of mailed dosimetry audits of proton therapy centres in Europe has led researchers to compare existing passive detector systems in therapeutic pencil beam scanning. The study found that alanine detectors have the lowest energy dependence for different parameters of therapeutic pencil beam scanning and are suitable for mail auditing in proton therapy. The luminescence detector systems show promise, but more careful calibration and corrections are needed for implementation as part of a mailed dosimetry audit system.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Engineering, Biomedical
Alexandra Bourgouin, Thomas Hackel, Marco Marinelli, Rafael Kranzer, Andreas Schueller, Ralf-Peter Kapsch
Summary: The aim of this study was to evaluate the dose response of PTB's alanine dosimeter system in UHPDR electron beams, with results showing a good precision of the system in the dose range of 0.15 Gy to 6.2 Gy per pulse. The Monte Carlo simulations were used to determine the beam quality conversion and correction factors needed for alanine dosimetry.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Environmental Sciences
Amna Hassan, Margarita Tzivaki, Lukas Felner, Edward Waller
Summary: This study investigates the feasibility of using alanine powder as a standardized dosimeter for the alanine-EPR system. A calibration curve was produced and the dosimetric signal showed linear behavior with good repeatability.
Article
Engineering, Biomedical
Simon Jensen, Ludvig P. Muren, Peter Balling, Jorgen B. B. Petersen, Lia B. Valdetaro, Per R. Poulsen
Summary: This study investigated the dose perturbation caused by dynamic motion and deformation during proton pencil beam deliveries using deformable 3D dosimeters. Results showed that dose delivery was accurate and efficient when gating was employed during motion experiments, while unstable delivery was observed without gating.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Review
Multidisciplinary Sciences
Kunming Tian, Sayoko Ogura, Peter J. Little, Suo-wen Xu, Tatsuya Sawamura
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2019)
Article
Cell Biology
Danielle Kamato, Micah Burch, Ying Zhou, Raafat Mohamed, Jennifer L. Stow, Narin Osman, Wenhua Zheng, Peter J. Little
CELLULAR SIGNALLING
(2019)
Review
Pharmacology & Pharmacy
Xiaojun Feng, Yi Li, Yanan Wang, Lingli Li, Peter J. Little, Suo-wen Xu, Sheng Liu
PHARMACOLOGICAL RESEARCH
(2019)
Article
Cell Biology
Raafat Mohamed, Parisa Dayati, Reyhaneh Niayesh Mehr, Danielle Kamato, Faezeh Seif, Hossein Babaahmadi-Rezaei, Peter J. Little
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2019)
Review
Pharmacology & Pharmacy
Yicong Zhang, Aayushi Koradia, Danielle Kamato, Amirali Popat, Peter J. Little, Hang T. Ta
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Clare L. Smith, Atousa Montesari, Christopher P. Oliver, Duncan J. Butler
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2020)
Review
Medicine, Research & Experimental
Danielle Kamato, Peter J. Little
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Cell Biology
Xia Zhao, Chao Han, Zhiwen Zeng, Linlin Liu, Haitao Wang, Jiangping Xu, Zhong-Ping Feng, Peter J. Little, Remi Quirion, Wenhua Zheng
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Masao Nakayama, Clare L. Smith, Bryce N. Feltis, Terrence J. Piva, Farnaz Tabatabaie, Peter D. Harty, Frank M. Gagliardi, Kirsten Platts, Sarah Otto, Anton Blencowe, Kenta Morita, Moshi Geso
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Ying Zhou, Peter J. Little, Yingnan Cao, Hang T. Ta, Danielle Kamato
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Ying Zhou, Peter J. Little, Suowen Xu, Danielle Kamato
Summary: Curcumin, a natural compound widely used in Asian countries, has anti-inflammatory and anti-oxidative properties. Researchers have found that curcumin can prevent atherosclerosis by blocking ROCK signaling pathway.
Review
Pharmacology & Pharmacy
Suowen Xu, Iqra Ilyas, Peter J. Little, Hong Li, Danielle Kamato, Xueying Zheng, Sihui Luo, Zhuoming Li, Peiqing Liu, Jihong Han, Ian C. Harding, Eno E. Ebong, Scott J. Cameron, Alastair G. Stewart, Jianping Weng
Summary: The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in maintaining multiorgan health and homeostasis. Dysfunction of the vascular endothelium is associated with various diseases and is implicated in severe coronavirus disease 2019. Therapeutic approaches targeting endothelial dysfunction may have potential for treatment of cardiovascular and many other diseases.
PHARMACOLOGICAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Danielle Kamato, Iqra Ilyas, Suowen Xu, Peter J. Little
Summary: Cardiovascular disease, primarily caused by atherosclerosis, is the leading cause of disease-related mortality worldwide. Current therapeutic agents have limited efficacy in lowering plasma lipid levels and reducing deaths from cardiovascular disease. Suitable animal models that accurately reproduce human atherosclerosis are essential for pre-clinical research on novel cardiovascular drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xiumei Wu, Mengyun Xu, Mengya Geng, Shuo Chen, Peter J. Little, Suowen Xu, Jianping Weng
Summary: The increasing prevalence of noncommunicable diseases (NCDs) has become a significant global public health burden. Metabolic diseases, the most common form of NCDs, have life-threatening cardiovascular complications and affect people of all ages. Protein posttranslational modification (PTM) greatly enhances the functional diversity of proteins and plays a crucial role in common metabolic diseases such as diabetes, obesity, and fatty liver diseases. Understanding the mechanisms of PTMs in metabolic diseases will provide new insights for therapeutic intervention and improvement of therapies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Ying Zhou, Hirushi Kumarapperuma, Salifya Sichone, Zheng Jie Chia, Peter J. Little, Suowen Xu, Danielle Kamato
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)