Article
Fisheries
Cheng-dong Jin, Mo-fei Li
Summary: The study demonstrates that Omp1Et is a surface-located virulence factor of E. tarda, and recombinant Omp1Et can effectively induce immune protection as a subunit vaccine.
Article
Biochemistry & Molecular Biology
Xue-Peng Li, Jian Zhang
Summary: This study utilized RNA-Seq technology to investigate the molecular mechanism of fish immune response following TXhfq vaccination, revealing a large number of differentially expressed genes in different tissues, with implications in six immune-related categories. A protein-protein interaction network highlighted the significance of the top six hub genes regulated by TXhfq in immune processes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Fisheries
Jingjing Cao, Kunihiko Futami, Masashi Maita, Teruyuki Nakanishi, Takayuki Katagiri
Summary: This study investigated the immune response and vaccine efficacy in fish vaccinated with different vaccines. The results showed that the allogeneic + FKC group had the best protection effect, achieved through the induction of CMI. The study provides important information for vaccine development.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Mohd Hafiz Ngoo Muhamad-Sofie, Aslah Mohamad, Mohamad Azzam-Sayuti, Jing Yie Lee, Wan Haifa Haryani Wan Omar, Yong Kit Chin, Mohammad Noor Azmai Amal, Salleh Annas, Mohd Zamri-Saad, Md Yasin Ina-Salwany
Summary: This study evaluates the effectiveness of three live-attenuated Vibrio harveyi vaccines in providing immunological protection to zebrafish offspring against pathogenic Vibrio spp. The results show that freeze-dried and stale LAVh vaccines provide longer immunological protection, while the FKVh vaccine group fails to protect against V. alginolyticus. However, both vaccine groups display 100% immunity against pathogenic Vibrio spp. The freeze-dried LAVh vaccine confers maternal immune protection to offspring, has a longer duration of immunological protection and cross-protection, and a longer shelf life, making it a potential commercial option for preventing Vibrio spp. infection.
AQUACULTURE RESEARCH
(2023)
Article
Fisheries
Yunji Xiu, Baoshan Guo, Jingyuan Yi, Huimin Guo, Hetron Mweemba Munang'andu, Cheng Xu, Shun Zhou
Summary: This study used RNA-seq to analyze the transcriptomic profile of kidney tissue in turbot after immunization with an inactivated bivalent vaccine against Aeromonas salmonicida and Edwardsiella tarda. The results revealed that the vaccine induced upregulation and downregulation of immune-related genes, including cytokines, complement system, and chemokines, enhancing the immune response against these pathogens in turbot.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Tasok Leya, Rajendran Kooloth Valappil, Gayatri Tripathi, Pani Prasad Kurcheti, Megha Kadam Bedekar
Summary: In this study, the expression of pIgR gene in Labeo rohita in response to a pDNA vaccine was characterized and its correlation with IgM expression in mucosal tissues was analyzed. The results showed a positive correlation between the expression of pIgR and IgM, suggesting a possible role of pIgR as an IgM transporter in L. rohita.
Review
Immunology
Jue Hou, Weijian Ye, Jianzhu Chen
Summary: Dengue is a common mosquito-borne disease caused by four closely related viruses. Developing a vaccine that can protect against all four virus strains without adverse effects is a challenge. Several tetravalent live attenuated vaccine candidates have entered clinical trials.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Adrian Lopez-Porras, Matt J. Griffin, Cynthia Ware, Bradley M. Richardson, Terrence E. Greenway, Thomas Graham Rosser, Suja Aarattuthodiyi, David J. Wise
Summary: Edwardsiella piscicida is a growing problem in catfish aquaculture in the southeastern United States, especially in channel and hybrid catfish. Multiple phyletic groups of E. piscicida have been identified, with no significant differences in virulence between channel and hybrid catfish. A live-attenuated E. ictaluri vaccine has shown cross-protection against one E. piscicida isolate, but its effectiveness against other variants is unknown. Exposure to heterologous E. piscicida isolates improves survival following E. ictaluri challenge, suggesting the presence of shared and conserved antigens.
JOURNAL OF FISH DISEASES
(2022)
Article
Immunology
Vu Thuy Khanh Le-Trilling, Andreja Jagnjic, Ilija Brizic, Mareike Eilbrecht, Kerstin Wohlgemuth, Carmen Rozmanic, Alan Herdman, Katja Hoffmann, Astrid M. M. Westendorf, Hartmut Hengel, Stipan Jonjic, Mirko Trilling
Summary: Human cytomegalovirus (HCMV) can cause congenital infections with birth defects and developmental disorders. A vaccine is currently not available. In this study, CMV mutants lacking STAT2 antagonists were examined as potential live attenuated vaccine viruses in mice. Vaccination with these attenuated viruses induced strong immune responses, including neutralizing antibodies and antibodies stimulating cellular Fc gamma receptors. Vaccinated mice were fully protected against challenge infections and maternal antibodies were found to be indispensable for vaccine-induced protection against cytomegaloviruses.
Article
Immunology
Palanisamy Bothammal, Mohan Ganesh, Vellaisamy Vigneshwaran, Kumarasamy Anbarasu, Karuppiah Ponmurugan, Naif Abdullah Al-Dhabi, Kalimuthusamy Natarajaseenivasan
Summary: The study identified immune expressive proteins HflC, HflK, and YhcI which showed a 60% survivability in clearing Edwardsiella from the host. These immunoreactive proteins induced a strong immune response post-infection, leading to significant production of IL-10, IFN-gamma, Th1, and Th2 mediated mRNA expression, thus proving effective in vaccine production for edwardsiellosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Hiroaki Saito, Takumi Okamura, Tomoya Shibata, Goshi Kato, Motohiko Sano
Summary: The study aimed to attenuate the pathogenicity of CyHV-2 through serial subculture in order to develop a live attenuated vaccine as a preventive measure against herpesviral hematopoietic necrosis in goldfish farming.
Article
Fisheries
Mohamed Sayed, Ozan Ozdemir, Manal Essa, Alicia Olivier, Attila Karsi, Mark L. Lawrence, Hossam Abdelhamed
Summary: This study constructed two in-frame deletion mutants of Edwardsiella piscicida strain C07-087 by deleting the phoP (ETAC_09785) and phoQ (ETAC_09790) genes. The mutants showed delayed adaptation to oxidative stress and decreased biofilm formation, as well as significantly reduced virulence in channel catfish and increased protection efficacy after vaccination. The results suggest that PhoP and PhoQ are crucial for bacterial adaptation and infection in catfish.
JOURNAL OF FISH DISEASES
(2021)
Article
Fisheries
Lin Su, Huimin Guo, Baoshan Guo, Jingyuan Yi, Zongrui Yang, Shun Zhou, Yunji Xiu
Summary: In recent years, combination vaccines have become necessary to prevent fish diseases caused by multiple infections simultaneously. In this study, an inactivated bivalent vaccine was prepared for Aeromonas salmonicida and Edwardsiella tarda. After vaccination, the vaccinated turbot showed a relative percentage survival (RPS) of 77.1% when challenged with A. salmonicida and E. tarda. The study also found that the vaccinated group had upregulated serum antibody titer and lysozyme activity, as well as increased expression levels of genes related to antigen recognition, processing, and presentation.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Bei Li, Jianlin Chen, Pujiang Huang, Tingting Weng, Yiming Wen, Huiyuan Yang, Yansheng Liu, Liqun Xia
Summary: This study successfully obtained two attenuated N. seriolae strains S-250 and U-20, which demonstrated strong immune response and provided protective efficacy against N. seriolae in hybrid snakehead. These attenuated strains are potential candidates for the development of live vaccines to control fish nocardiosis in aquaculture.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Munish Puri, Socorro Miranda-Hernandez, Selvakumar Subbian, Andreas Kupz
Summary: Tuberculosis (TB) is a deadly infectious disease, and the only approved vaccine, BCG, provides limited protection against pulmonary TB in adults. Delivering BCG directly into the lungs has shown enhanced immune responses and greater protection against TB. This article discusses the repurposing of existing inhalation devices for mucosal delivery of live attenuated TB vaccines and outlines the challenges and research questions that need to be addressed for their use in TB endemic countries.
FRONTIERS IN IMMUNOLOGY
(2023)
