Article
Engineering, Chemical
Savana J. Ismael, Omid Amiri, Sangar S. Ahmed
Summary: This paper investigates the synthesis and characterization of La1_ xMn1_yO3 nanostructures as a piezo catalyst for the treatment of medical waste. The catalysts were analyzed using various techniques and the effects of catalyst dosage, drug concentration, pH, and ultrasonic power on degradation efficiency were studied.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Engineering, Chemical
Savana J. Ismael, Omid Amiri, Sangar S. Ahmed
Summary: This paper focuses on the synthesis and characterization of La1-xMn1-yO3 nanostructures as an efficient piezo catalyst for treating pharmaceutical waste. The performance of the catalyst in degrading various drugs was evaluated, and the effects of different parameters on degradation efficiency were investigated. The results showed that the prepared catalysts could degrade the drugs waste by over 90%.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Microbiology
Andy Hesketh, Giselda Bucca, Colin P. Smith, Hee-Jeon Hong
Summary: Dalbavancin, vancomycin, and chlorobiphenyl-vancomycin are glycopeptide antibiotics with similar structures and modes of action, but they induce different gene expression patterns and have diverse impacts on bacterial cell wall biosynthesis and other physiological processes.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Oleksandr Yushchuk, Kseniia Zhukrovska, Bohdan Ostash, Victor Fedorenko, Flavia Marinelli
Summary: Glycopeptide antibiotics (GPAs) are successful antimicrobials that inhibit cell-wall biosynthesis in Gram-positive bacteria. Self-resistance genes in GPA producers are the primary source of GPA resistance genes spreading among pathogenic bacteria. The role of Tei3 sensor histidine kinase in GPA resistance in Actinoplanes teichomyceticus has been intensively studied and a possible co-evolution scenario for GPA-resistance and biosynthetic genes in A. teichomyceticus has been proposed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yifei Song, Jingkai Zhang, Yue Fei, Zhangjian Huang, Xiaoxuan Liu, Li-Li Li
Summary: In this study, a glycopeptide-based antibiotic nano-adjuvant (GalAc-2) was proposed to enhance the antibacterial activity of antibiotics by inhibiting biofilm formation. Experimental results showed that GalAc-2 synergistically inhibited bacterial biofilm formation with antibiotics, significantly reduced abscess formation and immune cell infiltration, which suggests its potential in enhancing antibiotic sensitization and extending the lifetime of antibiotics.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Infectious Diseases
Andres Andreo-Vidal, Elisa Binda, Victor Fedorenko, Flavia Marinelli, Oleksandr Yushchuk
Summary: The global health security is challenged by the spread of antimicrobial resistance, affecting even glycopeptide antibiotics. Research has shown that GPA resistance determinants can be found not only in GPA producers, but also in non-producers, indicating a co-evolution of different vlgs.
Article
Chemistry, Multidisciplinary
Anja Greule, Thierry Izore, Daniel Machell, Mathias H. Hansen, Melanie Schoppet, James J. De Voss, Louise K. Charkoudian, Ralf B. Schittenhelm, Jeffrey R. Harmer, Max J. Cryle
Summary: Cytochrome P450 enzymes are enzymes that can perform oxidative reactions using heme. However, some of these enzymes can be damaged by oxidation, leading to decreased enzyme activity. Research has shown that the heme orientation in the active site of certain cytochrome P450 enzymes may contribute to this oxidative damage.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Vladimir Vimberg, Leona Zieglerova, Aninda Mazumdar, Zsolt Szucs, Aniko Borbas, Pal Herczegh, Gabriela Balikova Novotna
Summary: This paper compares the in vitro activities of two new semisynthetic glycopeptide antibiotics with two clinically used glycopeptide antibiotics, finding that the new antibiotics effectively kill various states of Staphylococcus aureus cells.
Article
Biochemical Research Methods
John William Young, Zhiyu Zhao, Irvinder Singh Wason, Franck Duong van Hoa
Summary: The outer membrane of Gram-negative bacteria is crucial for cell protection and antimicrobial discovery. A new method for isolating the outer membrane proteome has been developed, enabling further studies and potential discovery of antimicrobials.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Christopher R. Apostol, Parthasaradhireddy Tanguturi, Lajos Z. Szabo, Daniel Varela, Thiago Gilmartin, John M. Streicher, Robin Polt
Summary: This study synthesized shortened glycopeptide analogues of PACAP(1-23) and found that these analogues strongly interact with the PAC1 and VPAC1 receptors, while showing reduced activity at the VPAC2 receptor.
Article
Genetics & Heredity
Oleksandr Yushchuk, Elisa Binda, Victor Fedorenko, Flavia Marinelli
Summary: This study identified new classes of bacteria, including Erysipelotrichia, Ktedonobacteria, and Anaerolineae, that carry van genes, in addition to the Actinobacteria phylum. The discovery of these bacteria carrying van genes provides insights into the possible routes of van gene dissemination. The study also proposes a phylogeny-based scenario for the spread of van genes, revealing a network of horizontal gene transfer events.
Article
Microbiology
Mohamad Maatouk, Ahmad Ibrahim, Jean-Marc Rolain, Vicky Merhej, Fadi Bittar
Summary: Candidate Phyla Radiation (CPR) microbes have been identified as a new branch in the tree of life, representing over 26% of microbial diversity. Despite their small size, reduced genomes, and reliance on symbiotic relationships with bacterial hosts, CPR microbes are abundant in various environments. They possess a diverse range of antibiotic resistance genes and are active participants in microbial competition, equipped with mechanisms for combat in different habitats.
Article
Pharmacology & Pharmacy
Xinling Cui, Wei Mi, Zhishang Hu, Xiaoyu Li, Bo Meng, Xinyuan Zhao, Xiaohong Qian, Tao Zhu, Wantao Ying
Summary: Posttranslational modifications of antibody products have a significant impact on their quality attributes. This study aimed to comprehensively characterize the posttranslational modification status of antibody drug charge isomers (CIs) and investigate the effect of modifications on charge heterogeneity. Through structural characterization at different levels, the study revealed the dynamics of glycoforms and the importance of sialic acid modification in accounting for charge heterogeneity.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Biotechnology & Applied Microbiology
Elisa Binda, Francesca Berini, Flavia Marinelli, Adriana Bava, Fabrizio Beltrametti
Summary: Exposing N. gerenzanensis wild-type population to sub-inhibitory concentrations of A40926 led to the isolation of differently resistant phenotypes, with the most resistant population (G) producing twice as much A40926 at bioreactor scale compared to the wild-type. This paves the way for rational strain improvement based on the selection of increasingly self-resistant colonies.
FERMENTATION-BASEL
(2021)
Review
Spectroscopy
Wenjing Peng, Cristian D. Gutierrez Reyes, Sakshi Gautam, Aiying Yu, Byeong Gwan Cho, Mona Goli, Kaitlyn Donohoo, Stefania Mondello, Firas Kobeissy, Yehia Mechref
Summary: Glycosylation is a significant posttranslational modification in mammalian cells, involved in various biofunctions and diseases. Mass spectrometry is a powerful tool for glycan and glycopeptide isomeric analysis, but its comprehensive characterization remains a challenge. Separation methods and bioinformatic tools are applied to address this challenge.
MASS SPECTROMETRY REVIEWS
(2023)