Article
Medicine, General & Internal
Valters Viksne, Ilze Strumfa, Maris Sperga, Janis Ziemelis, Juris Abolins
Summary: The goal of this research was to examine the morphology of the lungs in COVID-19 patients who died in Latvia. The study found that the majority of patients had diffuse alveolar damage, vascular damage, and signs of thrombosis in their lung tissue. These histological findings can be considered representative of severe COVID-19.
Article
Medicine, General & Internal
Ching-Ying Huang, Patricia Wanping Wu, Yon-Cheong Wong, Kuo-Chin Kao, Chung-Chi Huang
Summary: This study examined the use of high-resolution computed tomography (HRCT) findings and HRCT scores to predict the 60-day mortality related to diffuse alveolar damage (DAD), a pathological hallmark of acute respiratory distress syndrome (ARDS). The results showed that the total percentage of the area with bronchiectasis or bronchiolectasis on HRCT in early ARDS was an independent positive predictor of 60-day mortality of DAD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Alain Boussuges, Jeremy Bourenne, Farid Eloufir, Julien Fromonot, Giovanna Mottola, Jean Jacques Risso, Nicolas Vallee, Fabienne Bregeon, Regis Guieu
Summary: Exposure to extreme oxygen partial pressures can induce changes in the adenosinergic system, which play important roles in protecting the brain and lungs in high-altitude and deep-sea environments. Increased adenosine concentration helps protect the brain against hypoxia and is involved in the pathogenesis of mountain illness and neurological disorders. It also contributes to the prevention of high-altitude pulmonary edema and lung oxygen toxicity. On the other hand, decreased adenosine concentration during hyperoxic exposure leads to vasoconstriction and decreased cerebral blood flow, serving as a preventive measure against cerebral oxygen toxicity.
Article
Multidisciplinary Sciences
Dayoung Oh, Ward De Spiegelaere, Hans J. Nauwynck
Summary: Porcine alveolar macrophages (PAMs) were used to study porcine respiratory viruses in vitro. Stable reference genes, PSAP and GAPDH, were identified for reliable normalization of target gene expression. This study highlights the importance of selecting appropriate reference genes for normalization and validation of RT-qPCR data in various experimental conditions. The identified reference genes will be useful for future studies on porcine respiratory viruses in PAMs.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Dong Li, Huan Yao, Lei Du, Xianyin Zeng, Qihai Xiao
Summary: Thallium exposure can cause liver damage and disrupt hepatic fatty acid metabolism.
Article
Medicine, General & Internal
Jonas S. Erjefalt, Natalia de Souza Xavier Costa, Jimmie Jonsson, Olga Cozzolino, Katia Cristina Dantas, Carl-Magnus Clausson, Premkumar Siddhuraj, Caroline Lindo, Manar Alyamani, Suzete Cleusa Ferreira Spina Lombardi, Alfredo Mendroni Junior, Leila Antonangelo, Caroline Silverio Faria, Amaro Nunes Duarte-Neto, Renata Aparecida de Almeida Monteiro, Joao Renato Rebello Pinho, Michele Soares Gomes-Gouvea, Roberta Verciano Pereira, Jhonatas Sirino Monteiro, Joao Carlos Setubal, Ellen Pierre de Oliveira, Jair Theodoro Filho, Caroline Sanden, Jamie M. Orengo, Matthew A. Sleeman, Luiz Fernando Ferraz da Silva, Paulo Hilario Nascimento Saldiva, Marisa Dolhnikoff, Thais Mauad
Summary: This study provides spatially decoded analyses on the immunopathology of diffuse alveolar damage (DAD) patterns and factors that modulate immune and structural changes in fatal COVID-19. The findings reveal the spatial and molecular immunopathology of COVID-19 cases, highlighting the responses to SARS-CoV-2-induced exudative DAD and subsequent immune-modulatory and remodeling changes in proliferative/advanced DAD that occur alongside secondary infections in the lungs.
Article
Biochemistry & Molecular Biology
Anna Allue-Guardia, Andreu Garcia-Vilanova, Angelica M. Olmo-Fontanez, Jay Peters, Diego J. Maselli, Yufeng Wang, Joanne Turner, Larry S. Schlesinger, Jordi B. Torrelles
Summary: This study reveals that Mycobacterium tuberculosis (M.tb) alters the expression of its cell envelope genes upon contact with alveolar lining fluid (ALF). The dysfunctional ALF of elderly individuals, characterized by impaired innate soluble responses and high oxidative stress, may play an important role in determining infection outcome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Maria Karolina Martins Ferreira, Deiweson Souza-Monteiro, Leonardo Oliveira Bittencourt, Jose Mario Matos-Sousa, Vinicius Ruan Neves Santos, Paula Beatriz Oliveira Nunes, Gabriela de Souza Balbinot, Alejandro Ferraz Prado, Fabricio Mezzomo Collares, Francisco Jose Ager, Ines Ortega-Feliu, Miguel Angel Respaldiza, Sofia Pessanha, Rafael Rodrigues Lima
Summary: This study investigated the effects of fluoride exposure during pregnancy and breastfeeding on the alveolar bone of the offspring. The results showed that fluoride exposure increased fluoride levels in the alveolar bone, altered the chemical components of the bone, affected the microstructure of the alveolar bone, and reduced the amount of bone tissue, leading to increased root exposure area.
Article
Multidisciplinary Sciences
Magdalena Sozoniuk, Monika Jamiol, Marta Kankofer, Krzysztof Kowalczyk
Summary: This study aimed to identify endogenous reference genes with stable expression for transcriptional regulation research during pregnancy establishment and maintenance. RPS9 and SUZ12 were found to be the most suitable reference genes, and they can be used for studying gene expression in both normal and compromised pregnancies.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Zhongnan Yang, Lei Yan, Huixia Cao, Yue Gu, Pan Zhou, Mingyue Shi, Guodong Li, Xiaojing Jiao, Na Li, Xiangnan Li, Kai Sun, Fengmin Shao
Summary: The study showed that erythropoietin (EPO) can alleviate diffuse alveolar hemorrhage (DAH) by reducing macrophage recruitment and promoting phenotype switch, suggesting its potential as a therapeutic agent for DAH. Further research is needed to validate the direct target of miR-494-3p in regulating JAK2/STAT3 signaling transduction.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Liang-Ti Huang, Hsiu-Chu Chou, Chung-Ming Chen
Summary: The study revealed that exposure to hyperoxia upregulates TRIM72 expression, leading to oxygen-induced lung injury, possibly through TRIM72-dependent alveolar epithelial cell death.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Biotechnology & Applied Microbiology
Jun Jiang, Juan Wang, Cen Li, Lianqin Mo, Dong Huang
Summary: Oxygen therapy and mechanical ventilation are commonly used methods to treat critically ill newborns, but they often lead to adverse effects such as chronic lung disease. This study established an in vitro model to investigate the molecular basis of hyperoxia-induced lung damage in type II alveolar epithelial cells (AECIIs). The results showed that SMAD/ERK signaling plays a critical role in regulating AECII behavior in different oxygen environments.
Article
Medicine, General & Internal
Yu-Chun Lo, Kai-Yun Chen, Hsiu-Chu Chou, I-Hsuan Lin, Chung-Ming Chen
Summary: Neonatal hyperoxia disrupts intestinal tight junction protein expression, alters gut microbiota composition, reduces brain myelination, and leads to deficits in social interaction and motor coordination in adolescent mice.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Environmental Sciences
Aline G. G. Aun, Debora C. Damasceno, Yuri K. K. Sinzato, Flavia R. Nogueira, Katina M. Souza, Youssef S. A. Lawi, Julia L. Guedes, Mariane A. P. Silva, Lidia R. de Carvalho, Leandro G. G. Braz, Mariana G. G. Braz
Summary: Evaluation of the possible toxic effects of occupational exposure to anesthetics is limited. This cohort study assessed oxidative stress, DNA damage, and gene expression in physicians occupationally exposed to modern anesthetics during their residency period. The results showed induction of oxidative stress, gene expression modulation, and genotoxicity in physicians during their specialization period.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cell Biology
Anelya Kh Alieva, Elena Filatova, Margarita M. Rudenok, Petr A. Slominsky, Maria Shadrina
Summary: Selecting the correct housekeeping genes is crucial for normalizing gene expression data in real-time PCR. In Parkinson's disease, different housekeeping genes are stably expressed in different parts of the brain and in similar tissues of different organisms.
Article
Medicine, Legal
Shigeki Tsuneya, Makoto Nakajima, Maiko Yoshida, Yumi Hoshioka, Fumiko Chiba, Go Inokuchi, Suguru Torimitsu, Hirotaro Iwase
Summary: This case report highlights the detection of diatoms in a non-drowned human who had aspirated mud. Careful analysis of diatoms in various samples can help differentiate true drowning from false-positives in non-drowning cases.
Article
Medicine, Legal
Jessika Camatti, Ivan Galliani, Antonello Cirnelli, Rossana Cecchi
Summary: This article presents a case study on the evaluation of criminal responsibility of a murderer. The multidisciplinary approach was used to investigate and analyze the case, and through psychological tests and interviews, experts concluded that the accused cannot be exempted from criminal responsibility for the homicide.
