期刊
LEARNING & MEMORY
卷 18, 期 2, 页码 80-84出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/lm.2006511
关键词
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资金
- Australian Research Council [DP0985554]
- Australian Postgraduate Award
- Australian Research Council [DP0985554] Funding Source: Australian Research Council
These experiments examined the effects of the NMDA-receptor (NMDAr) antagonist MK801 on reacquisition and re-extinction of a conditioned fear that had been previously extinguished before injection of fibroblast growth factor-2 (FGF2) or vehicle. Recent findings have shown that relearning and re-extinction, unlike initial learning and extinction, do not depend on NMDAr activation. Three experiments demonstrated that FGF2 prevents the switch from NMDAr-dependent to NMDAr-independent reacquisition and re-extinction, suggesting that FGF2 may lead to the partial erasure of the original fear memory. These findings add to a growing body of work suggesting that FGF2 may be a novel pharmacological enhancer of exposure therapy for humans with anxiety disorders.
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