Article
Multidisciplinary Sciences
Sergei Korneev, Jekaterina Garaliene, Gabriella Taylor, Ildiko Kemenes, Gyorgy Kemenes
Summary: Long natural antisense transcripts (NATs) are prevalent in eukaryotic organisms, particularly in the nervous system; Lym-NOS1AS is co-expressed with Lym-NOS1 mRNA in a key neuron of the memory network; Lym-NOS1AS plays a crucial role in nitric oxide-dependent long-term memory consolidation and is regulated by one-trial conditioning.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Jiyeon Seo, Hongik Hwang, Yuri Choi, Sunmin Jung, Jung-Hwa Hong, Bong-June Yoon, Hyewhon Rhim, Mikyoung Park
Summary: Many psychiatric disorders are associated with deficits in cognitive functions and synaptic plasticity, which are linked to abnormal lipid modifications of neuronal proteins. Cyclin Y (CCNY), located in the postsynaptic compartment, plays an inhibitory role in synaptic plasticity and spatial learning through myristoylation and palmitoylation.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Neurosciences
Chih-Chieh Wang, Christopher Weyrer, Diasynou Fioravante, Pascal S. Kaeser, Wade G. Regehr
Summary: The study found that even with the elimination of PKC phosphorylation sites on Munc18-1, synaptic transmission between hippocampal and cerebellar neurons can still be enhanced through other mechanisms, including PTP. This suggests that PKC regulation is not the sole factor affecting neuronal conduction.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
P. Robin, T. Emmerich, A. Ismail, A. Nigues, Y. You, G. -H. Nam, A. Keerthi, A. Siria, A. K. Geim, B. Radha, L. Bocquet
Summary: Experiments reveal the emergence of memory in the transport of electrolytes across nanoscale channels, which lays the foundation for biomimetic computations.
Article
Neurosciences
Peter H. Chipman, Richard D. Fetter, Lauren C. Panzera, Samuel J. Bergerson, Daniel Karmelic, Sae Yokoyama, Michael B. Hoppa, Graeme W. Davis
Summary: Homeostatic plasticity is a physiological process that counteracts neuronal perturbations in the brain. Acute AMPAR-specific antagonism can induce compensatory plasticity, leading to potentiation of presynaptic neurotransmitter release. This process can be induced within minutes and requires postsynaptic NMDARs.
Article
Multidisciplinary Sciences
David Vandael, Yuji Okamoto, Peter Jonas
Summary: Post-tetanic potentiation (PTP) is a major form of plasticity at hippocampal mossy fiber synapses and is considered an entirely presynaptic phenomenon. The authors show that mossy fiber PTP not only lacks associativity, but rather shows anti-associative induction properties, implementing a brake on mossy fiber detonation.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Benjamin Compans, Come Camus, Emmanouela Kallergi, Silvia Sposini, Magalie Martineau, Corey Butler, Adel Kechkar, Remco Klaassen, Natacha Retailleau, Terrence J. Sejnowski, August B. Smit, Jean-Baptiste Sibarita, Thomas M. Bartol, David Perrais, Vassiliki Nikoletopoulou, Daniel Choquet, Eric Hosy
Summary: Long-term depression (LTD) of synaptic strength is associated with circuit remodeling, memory encoding, and erasure. P2XR- and NMDAR-dependent LTD are linked to distinct molecular modifications that lead to specific changes in synapse function.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Iris Speigel, Kishan Patel, Vanessa Osman, Huge C. Hemmings Jr
Summary: Volatile anesthetics alter presynaptic function through effects on Ca2+ influx and neurotransmitter release, and this is mediated by the NO/cGMP signaling pathway. These findings provide new insights into the mechanisms of volatile anesthetics.
Review
Neurosciences
Ivan Goussakov, Sylvia Synowiec, Daniil P. Aksenov, Alexander Drobyshevsky
Summary: Chronic neonatal intermittent hypoxia causes functional disruption of synaptic plasticity in hippocampal neurons, resulting in pathological late phase hypoxic long term potentiation (hLTP) that can be reversed by depotentiation or abolished by inhibitors. Furthermore, late phase hLTP partially occludes normal physiological long term potentiation (pLTP) four hours after IH.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Jennifer Q. J. Zhang, Sayanthooran Saravanabavan, Kai Man Cheng, Aarya Raghubanshi, Ashley N. Chandra, Alexandra Munt, Benjamin Rayner, Yunjia Zhang, Katrina Chau, Annette T. Y. Wong, Gopala K. Rangan
Summary: The study found that L-arginine has a mild direct effect on reducing renal cyst growth in vitro, while long-term sodium nitrate supplementation was ineffective in vivo. This suggests that the bioconversion of dietary nitrate to NO through the entero-salivary pathway may not be sufficient to influence the progression of renal cyst growth in ADPKD.
Article
Cardiac & Cardiovascular Systems
Jody L. Greaney, Erika F. H. Saunders, Lacy M. Alexander
Summary: Activation of NF-kappa B, through increased vascular ROS production, contributes to reduced NO-dependent endothelial dilation in young adults with MDD. Short-term treatment with NF-kappa B inhibitor salsalate improves NO-mediated endothelium-dependent dilation in MDD patients, while acute localized ROS scavenging with apocynin enhances NO-dependent dilation before salsalate administration.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Younes Yassaghi, Sajad Jeddi, Nasibeh Yousefzadeh, Khosrow Kashfi, Asghar Ghasemi
Summary: Long-term nitrate intervention increased the resistance to myocardial ischemia-reperfusion injury (MIRI) in female rats, which was associated with increased heart endothelial nitric oxide synthase (eNOS) expression and circulating progesterone before ischemia and blunting ischemia-induced increased inducible nitric oxide synthase (iNOS) and decreased eNOS after MIRI.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Multidisciplinary Sciences
Xiumin Chen, Yuko Fukata, Masaki Fukata, Roger A. Nicoll
Summary: This study reveals the essential role of the MAGUK family of synaptic scaffolding proteins in LTP, with PSD-95 requiring binding to ADAM22 for synaptic transmission enhancement. Additionally, an alternative pathway involving SAP102 is proposed, independent of ADAM22.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Haden L. Scott, Dima Bolmatov, Peter T. Podar, Zening Liu, Jacob J. Kinnun, Benjamin Doughty, Ralph Lydic, Robert L. Sacci, C. Patrick Collier, John Katsaras
Summary: This study demonstrates that droplet interface bilayers (DIBs) composed of lipids can exhibit persistent synaptic plasticity, characterized by long-term potentiation (LTP) and capacitive energy storage. The time scales for the physical changes associated with LTP are longer than previous short-term synaptic plasticity studies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Alen Eapen, Diego Fernandez-Fernandez, John Georgiou, Zuner A. Bortolotto, Stafford Lightman, David E. Jane, Arturas Volianskis, Graham L. Collingridge
Summary: The study demonstrates the involvement of GluN2D-containing NMDARs in both short-term potentiation (STP) and long-term potentiation (LTP) in the mouse hippocampus, highlighting the important role of GluN2D subunits in synaptic plasticity.
Meeting Abstract
Biophysics
Victoria P. Johnstone, Abbie M. Adams, Steve D. Wilton, Sue Fletcher, Livia C. Hool
BIOPHYSICAL JOURNAL
(2015)
Article
Critical Care Medicine
Victoria P. A. Johnstone, David K. Wright, Kendrew Wong, Terence J. O'Brien, Ramesh Rajan, Sandy R. Shultz
JOURNAL OF NEUROTRAUMA
(2015)
Meeting Abstract
Biophysics
Livia C. Hool, Helena M. Viola, Victoria P. A. Johnstone, Henrietta Cserne Szappanos, Tatiana Tsoutsman, Chris Semsarian, Christine Seidman
BIOPHYSICAL JOURNAL
(2016)
Article
Critical Care Medicine
Benjamin J. Allitt, Victoria P. A. Johnstone, Katrina Richards, Edwin B. Yan, Ramesh Rajan
JOURNAL OF NEUROTRAUMA
(2016)
Review
Critical Care Medicine
Dasuni Sathsara Alwis, Edwin Bingbing Yan, Victoria Johnstone, Simone Carron, Sarah Hellewell, Maria Cristina Morganti-Kossmann, Ramesh Rajan
JOURNAL OF NEUROTRAUMA
(2016)
Article
Neurosciences
Helena Viola, Victoria Johnstone, Henrietta Cserne Szappanos, Tara Richman, Tatiana Tsoutsman, Aleksandra Filipovska, Christopher Semsarian, Livia Hool
JOURNAL OF PHYSIOLOGY-LONDON
(2016)
Review
Genetics & Heredity
Victoria P. A. Johnstone, Helena M. Viola, Livia C. Hool
Article
Multidisciplinary Sciences
Kara L. Perks, Nicola Ferreira, Tara R. Richman, Judith A. Ermer, Irina Kuznetsova, Anne-Marie J. Shearwood, Richard G. Lee, Helena M. Viola, Victoria P. A. Johnstone, Vance Matthews, Livia C. Hool, Oliver Rackham, Aleksandra Filipovska
Article
Chemistry, Multidisciplinary
Naviin Hardy, Helena M. Viola, Victoria P. A. Johnstone, Tristan D. Clemons, Henrietta Cserne Szappanos, Ruhani Singh, Nicole M. Smith, K. Swaminathan Iyer, Livia C. Hool
Review
Biochemistry & Molecular Biology
Victoria P. A. Johnstone, Livia C. Hool
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2014)
Article
Multidisciplinary Sciences
Helena M. Viola, Ashay A. Shah, Victoria P. A. Johnstone, Henrietta Cserne Szappanos, Mark P. Hodson, Livia C. Hool
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Cardiac & Cardiovascular Systems
Helena M. Viola, Victoria P. A. Johnstone, Abbie M. Adams, Susan Fletcher, Livia C. Hool
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2018)
Article
Cell & Tissue Engineering
Benjamin J. Allitt, Victoria P. A. Johnstone, Katrina L. Richards, Edwin B. Yan, Ramesh Rajan
CELL TRANSPLANTATION
(2017)
Meeting Abstract
Biophysics
Helena M. Viola, Victoria P. A. Johnstone, Christopher Semsarian, Livia C. Hool
BIOPHYSICAL JOURNAL
(2017)
Meeting Abstract
Biophysics
Helena M. Viola, Victoria P. A. Johnstone, Abbie M. Adams, Susan Fletcher, Livia C. Hool
BIOPHYSICAL JOURNAL
(2017)