期刊
LEARNING & MEMORY
卷 18, 期 8, 页码 529-533出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/lm.2253311
关键词
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资金
- Junta de Andalucia, Spain [HUM 02763]
- MICINN, Spain [PSIC2008-03933]
We have investigated the effect of protein kinase Mzeta (PKM zeta) inhibition in the basolateral amygdala (BLA) upon the retention of a nonspatial learned active avoidance response and conditioned taste-aversion (CTA) acquisition in rats. ZIP (10 nmol/mu L) injected into the BLA 24 h after training impaired retention of a learned avoidance-jumping response assessed 7 d later when compared with control groups injected with scrambled-ZIP. Nevertheless, a retraining session applied 24 h later indicated no differences between the groups. Additionally, a similar ZIP injection into the BLA during the conditioned stimulus-unconditioned stimulus (CS-US) interval attenuated CTA acquisition. These findings support the BLA PKMz role in various forms of memory.
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