Article
Computer Science, Information Systems
Qiang Chang, Samuel Van De Velde, Heidi Steendam
Summary: This paper discusses a wireless positioning technique using Received Signal Strength (RSS) fingerprinting, which divides the database into multiple sub-databases with different densities to reduce data retrieval time and improve accuracy.
News Item
Multidisciplinary Sciences
Diana Kwon
Summary: Scientists are unraveling the process by which the brain controls immune responses in order to discover potential treatments for various diseases.
Article
Computer Science, Artificial Intelligence
Jingxuan Cai, Dan Ke, Jiang Wu, Xin (Robert) Luo
Summary: This study investigates the determinants of the usefulness of crowd testing reports and finds that the credibility of crowd testers and the information quality of the testing reports play significant roles. The presence of peer testers' reports also moderates the effect of information quality. These findings have managerial implications for effective implementation of crowd testing strategy and for creating useful testing reports.
DECISION SUPPORT SYSTEMS
(2022)
Article
Engineering, Mechanical
Frederic Lechenault, Iyad Ramdane, Sebastien Moulinet, Martin Roman-Faure, Matteo Ciccotti
Summary: Cutting mozzarella with a dull blade results in poorly shaped slices due to the deformation during the cutting process. Through the example of coring, we study the morphogenetics arising from this process, where the large transverse expansion leads to the clarinet-shape of the extracted core. By considering fracture mechanics and large strain theory, we develop a simple quantitative understanding of the observed discrepancy, which occurs when the punch size is smaller than a characteristic length scale. Material nonlinearity and friction also play a crucial role in this phenomenon.
EXTREME MECHANICS LETTERS
(2023)
Review
Immunology
Charlotte Hellmich, Edyta E. Wojtowicz
Summary: Normal bone marrow homeostasis relies on a steady supply of nutrients, and changes in metabolite demands can occur in response to infection and immune stress. The right balance of dietary components helps maintain normal homeostasis and cope with systemic stress. Some dietary components can also lead to chronic inflammation, impacting immune function. Optimal nutrition supports immune cell functions to effectively combat pathogens and resolve responses, while avoiding chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Imen Ferjani, Suleiman Ali Alsaif
Summary: This study focuses on improving road condition monitoring using machine learning methods. Conducting sensitivity analysis on three machine learning models to test the effectiveness by selecting features. Utilizing accelerometer datasets to achieve good classification performance in distinguishing road anomalies.
PEERJ COMPUTER SCIENCE
(2022)
Editorial Material
Immunology
Catterina Ferreccio
Summary: mRNA vaccine technology is the result of decades of research and has proven to be effective in preventing serious illness and death from COVID-19. It is a versatile platform that can be used against various diseases, including cancer, and is suitable for low-income countries due to its simplicity and relatively low cost. The unfair access to COVID-19 vaccines has led to vaccine hesitancy and anti-vaccine movements worldwide.
Article
Ecology
Rafael Molina-Venegas
Summary: Phylogenies are often misused as resources to predict missing values in trait datasets. The main issue is that many imputed values are trusted without convincingly demonstrating the data requirements, leading to potentially spurious predictions. The author advocates for a Monte-Carlo approach, based on trait simulations, to assess the expected accuracy of individual predictions and address the limitations of phylogenetic imputation.
METHODS IN ECOLOGY AND EVOLUTION
(2023)
Article
Polymer Science
Nicholas E. Leon, Zhongyun Liu, Maryam Irani, William J. Koros
Summary: This paper focuses on fundamental polymer science factors in membrane-based gas separation, emphasizing the importance of nanometer and angstrom scale matrix attributes in practical large-scale devices. Using specific examples, it discusses the effects of polymer structures, membrane morphologies, and operating conditions.
Editorial Material
Biochemistry & Molecular Biology
Zheng-Shan Chong, Sara Clohisey
Summary: Embarking on a PhD offers numerous opportunities for personal and professional development beyond scientific research. This article provides two perspectives on utilizing a wide range of skills and experiences to explore career opportunities outside academia, as well as tips on adjusting an academic CV to appeal to employers in different fields.
Article
Chemistry, Physical
Jun Lu, Chenglin Li, Hui Wang, Shan Ji, Xuyun Wang, Rongfang Wang
Summary: Direct seawater electrolysis is the main method for future hydrogen energy production, facing challenges due to chlorine evolution at the anode and cathode fouling. Alkali treatment of seawater is currently common but lacks a uniform standard. Growing NiFe LDH material on carbon cloth to explore optimal alkali treatment of seawater can reduce operating costs and prevent sedimentation impacts on equipment lifespan.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Engineering, Electrical & Electronic
Maniraman Periyasamy, Amirabbas Davari, Thorsten Seehaus, Matthias Braun, Andreas Maier, Vincent Christlein
Summary: This article studies and surveys the segmentation of glaciers (calving front) using a U-Net model, optimizing the model to achieve significant improvements in automatic delineation of SAR images. The optimized U-Net model shows remarkable advancements in glacier segmentation and front delineation.
IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING
(2022)
Article
Behavioral Sciences
Amy Shepherd, Tracy Zhang, Lucas B. Hoffmann, Ariel M. Zeleznikow-Johnston, Leonid Churilov, Anthony J. Hannan, Emma L. Burrows
Summary: This study evaluated the effects of touchscreen testing on hippocampal-dependent learning in the APP/PS1 mouse model, demonstrating that touchscreen training may enhance cognitive performance, increase neurogenesis, and mask cognitive deficits in mice.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Economics
Eleanya Nduka
Summary: Although Nigeria has abundant sustainable energy resources, rural households still heavily rely on conventional energy due to the inability to afford upfront costs. By implementing an installment plan, investors can improve welfare in rural areas through sustainable energy projects. Additionally, rural households exhibit a strong preference for sustainable energy, providing potential economic benefits for investors.
Editorial Material
Biochemistry & Molecular Biology
Marvin Choquet
Summary: Whole-genome sequencing remains difficult, costly, and time-consuming, but the emergence of genome reduced-representation sequencing protocols like RADseq has provided access to genome-wide information. The new software RADinitio allows for simulation of RADseq data and precise identification of failure sources in designing RADseq experiments. This advancement in RADseq data simulation is likely to improve success in RADseq experiments.
MOLECULAR ECOLOGY RESOURCES
(2021)
Review
Behavioral Sciences
Jacqueline A. Sullivan, Julie R. Dumont, Sara Memar, Miguel Skirzewski, Jinxia Wan, Maryam H. Mofrad, Hassam Zafar Ansari, Yulong Li, Lyle Muller, Vania F. Prado, Marco A. M. Prado, Lisa M. Saksida, Timothy J. Bussey
Summary: Neurodegenerative and neuropsychiatric diseases often lead to impairments in high-level cognitive functions, complicating the search for new treatments. The Mouse Translational Research Accelerator Platform (MouseTRAP) integrates touchscreen cognitive testing and neurotechnology to facilitate translational research, addressing key obstacles such as the lack of robust cognitive assessment tools. Touchscreencognition.org and mousebytes.ca are Open Science platforms designed to share knowledge and data within the rodent touchscreen community, enhancing collaboration and improving research outcomes.
GENES BRAIN AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Raquel Montalban-Loro, Glenda Lassi, Anna Lozano-Urena, Ana Perez-Villalba, Esteban Jimenez-Villalba, Marika Charalambous, Giorgio Vallortigara, Alexa E. Horner, Lisa M. Saksida, Timothy J. Bussey, Jose Luis Trejo, Valter Tucci, Anne C. Ferguson-Smith, Sacri R. Ferron
Summary: The study discovered that Delta-like homolog 1 is expressed biallelically in the adult brain, specifically in the hippocampus, and plays a crucial role in adult neurogenesis. Reduction in Dlk1 levels triggers specific cognitive abnormalities that affect discriminating differences in environmental stimuli, highlighting the importance of selective absence of imprinting in this neurogenic niche.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Amy C. Reichelt, Claire A. Lemieux, Oren Princz-Lebel, Ashmita Singh, Timothy J. Bussey, Lisa M. Saksida
Summary: The study reveals that excessive consumption of HFHS diets negatively impacts hippocampal and PFC function, resulting in reduced PV neurons and PNNs in the hippocampus of adult mice on HFHS diet, correlated with obesity, while no effects were seen in the PFC. Additionally, HFHS diet led to increased microglia in adults and activated microglia phenotypes in adolescents.
SCIENTIFIC REPORTS
(2021)
Review
Behavioral Sciences
Daniel Palmer, Julie R. Dumont, Tyler D. Dexter, Marco A. M. Prado, Elizabeth Finger, Timothy J. Bussey, Lisa M. Saksida
Summary: Computer-automated cognitive test batteries have the potential to improve translation between pre-clinical studies and clinical trials, facilitate data sharing and standardization, and address challenges in research on neurodegenerative and neuropsychiatric diseases.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Multidisciplinary Sciences
William T. Schneider, Szilvia Vas, Alister U. Nicol, A. Jennifer Morton
Summary: Research showed that in sheep with HD, transitions into wake were more sudden and accompanied by less reduction in slow wave power compared to normal sheep, indicating impaired readiness for waking. These abnormal dynamics of sleep transitions may potentially serve as an early biomarker for HD and could be applied to studying transition dynamics in other sleep disorders as well.
Article
Neurosciences
Xiaoyun Xu, Matthew Cowan, Flavio Beraldo, Amy Schranz, Patrick McCunn, Nicole Geremia, Zalman Brown, Maitray Patel, Karen L. Nygard, Reza Khazaee, Lihong Lu, Xingyu Liu, Michael J. Strong, Gregory A. Dekaban, Ravi Menon, Robert Bartha, Mark Daley, Haojie Mao, Vania Prado, Marco A. M. Prado, Lisa Saksida, Tim Bussey, Arthur Brown
Summary: Research has shown that even repetitive mild traumatic brain injuries (rmTBI) that do not reach the diagnostic threshold for concussion can have long-term effects on athletes, including brain damage, behavioral deficits, metabolic changes, etc., which may only become apparent months after the initial injury.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Review
Veterinary Sciences
Laura Lopez-Cruz, Timothy J. Bussey, Lisa M. Saksida, Christopher J. Heath
Summary: This study discusses the benefits of introducing touchscreen-based behavioral assessment apparatus in the field of behavioral neuroscience for refinement and reduction purposes. Data generated by specific behavioral tasks on this platform can enhance monitoring of laboratory animal welfare and provide robust, quantitative comparisons of husbandry techniques to define and ensure maintenance of best practice.
Article
Biochemistry & Molecular Biology
Sujeong Yang, Sylvain Gigout, Angelo Molinaro, Yuko Naito-Matsui, Sam Hilton, Simona Foscarin, Bart Nieuwenhuis, Chin Lik Tan, Joost Verhaagen, Tommaso Pizzorusso, Lisa M. Saksida, Timothy M. Bussey, Hiroshi Kitagawa, Jessica C. F. Kwok, James W. Fawcett
Summary: Perineuronal nets (PNNs), containing chondroitin sulphate proteoglycans on neuronal surfaces, play a role in neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) in PNNs leads to increased inhibition. Manipulating CS composition of PNNs can restore neuroplasticity and memory deficits in aged mice, with a focus on the importance of C6S in memory and neuroplasticity.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Ornela Kljakic, Helena Janickova, Miguel Skirzewski, Amy Reichelt, Sara Memar, Salah El Mestikawy, Yulong Li, Lisa M. Saksida, Timothy J. Bussey, Vania F. Prado, Marco A. M. Prado
Summary: In the striatum, cholinergic interneurons can release both acetylcholine and glutamate, and their individual and combined contributions to behavior regulation were assessed in mice using reward-based touchscreen tests. Changes in VAChT and VGLUT3 levels have different effects on reward responses, and the simultaneous loss of both vesicular transporters affects dopamine signaling and behavior in a more severe way than the loss of VAChT alone. This shows that the ability of CINs to secrete two different neurotransmitters allows for complex modulation of various behaviors.
Review
Hematology
Selen C. Muratoglu, Marc F. Charette, Zorina S. Galis, Adam S. Greenstein, Alan Daugherty, Anne Joutel, Beth A. Kozel, Donna M. Wilcock, Emily C. Collins, Farzaneh A. Sorond, Gareth R. Howell, Hyacinth I. Hyacinth, Kent K. C. Lloyd, Kurt R. Stenmark, Manfred Boehm, Mark L. Kahn, Roderick Corriveau, Sara Wells, Timothy J. Bussey, Stacey J. Sukoff Rizzo, M. Luisa Iruela-Arispe
Summary: Clinical investigations have shown that vascular-associated medical conditions are significant risk factors for dementia. However, the specific cognitive impairments associated with certain types of vascular deficiencies are still unclear. To address this, the National Heart, Lung, and Blood Institute has developed animal models to study vascular disease and its underlying causes. These models could be used as tools to link specific vascular signaling pathways with cognitive and neurobehavioral deficits related to dementia.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biology
Kayla M. Ferko, Anna Blumenthal, Chris B. Martin, Daria Proklova, Alexander N. Minos, Lisa M. Saksida, Timothy J. Bussey, Ali R. Khan, Stefan Koehler
Summary: Vision neuroscience has made significant progress in understanding the hierarchical organization of object representations, but there is limited research on the fine-grained visual similarities between objects that observers subjectively perceive. This study focused on the perceived visual similarities among real-world category exemplars and found that these similarities are most accurately reflected in the medial temporal lobe regions.
Review
Endocrinology & Metabolism
Olivia R. Ghosh-Swaby, Amy C. Reichelt, Paul A. S. Sheppard, Jeffrey Davies, Timothy J. Bussey, Lisa M. Saksida
Summary: This article discusses the role of metabolic hormones in neural plasticity and cognition, as well as the relationship between metabolic hormones and metabolic syndromes such as obesity and diabetes. Adjusting metabolic hormone levels can restore metabolic homeostasis and enhance cognitive function.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Rachel E. Lackie, Aline S. de Miranda, Mei Peng Lim, Vladislav Novikov, Nimrod Madrer, Nadun C. Karunatilleke, Benjamin S. Rutledge, Stephanie Tullo, Anne Brickenden, Matthew E. R. Maitland, David Greenberg, Daniel Gallino, Wen Luo, Anoosha Attaran, Irina Shlaifer, Esther Del Cid Pellitero, Caroline Schild-Poulter, Thomas M. Durcan, Edward A. Fon, Martin Duennwald, Flavio H. Beraldo, M. Mallar Chakravarty, Timothy J. Bussey, Lisa M. Saksida, Hermona Soreq, Wing-Yiu Choy, Vania F. Prado, Marco A. M. Prado
Summary: The co-chaperone STI1 interacts with alpha-synuclein and plays a role in its misfolding and aggregation. Decreased STI1 function can reduce protein inclusion formation and improve motor and cognitive deficits caused by alpha-synuclein overexpression.
ACTA NEUROPATHOLOGICA
(2022)
