期刊
LEARNING & MEMORY
卷 15, 期 8, 页码 597-602出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/lm.1029808
关键词
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资金
- Medical Research Council [9536855, G0600196, G0001354] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [G0600196] Funding Source: UKRI
- Medical Research Council [G0001354, G0600196, G0001354B] Funding Source: researchfish
The theory of memory reconsolidation relates to the hypothesized restabilisation process that occurs following the reactivation of a memory through retrieval. Thus the demonstration of reactivation-dependent amnesia for a previously acquired memory is a prerequisite for showing that such a memory undergoes reconsolidation. Here we show that the appetitive Pavlovian representations that underlie Pavlovian approach and Pavlovian-instrumental transfer are destabilized following their retrieval. This reactivation-dependent amnesia demonstrates that the general motivational or incentive properties of appetitive conditioned stimuli, as well as their conditioned reinforcing properties, can be reduced by blocking memory reconsolidation.
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