Article
Engineering, Biomedical
Melissa de Almeida Melo Maciel Mangueira, Egas Caparelli-Daquer, Ozimo Pereira Gama Filho, Diogo Souza Ferreira Rubim de Assis, Janyeid Karla Castro Sousa, Willy Leite Lima, Antonio Luiz Barbosa Pinheiro, Landulfo Silveira, Nilton Maciel Mangueira
Summary: This study evaluated the effects of low-level laser therapy (LLLT) on sciatic nerve regeneration after compression injury. The results showed that 660 nm laser treatment had a better therapeutic effect and effectively promoted neurofunctional recovery.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Cell Biology
Bruno Henrique de Melo Lima, Andre Luis Bombeiro, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues De Oliveira
Summary: The expression of MHC-I and other related molecules following peripheral nerve injury is associated with the recovery of neurons, glial cells, sensorimotor function, gait, and nociceptive threshold in mice. Different strains of mice exhibit varying recovery capacities.
Article
Engineering, Biomedical
Luana Gabriel de Souza, Ketlyn Germann Hendler, Alexandre Marcio Marcolino, Heloyse Uliam Kuriki, Ramon Bauer Cardoso, Marisa de Cassia Registro Fonseca, Rafael Inacio Barbosa
Summary: The study showed that PBM alone was more effective compared to Simvastatin alone or the combination of PBM and Simvastatin for sciatic nerve injury in mice.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Environmental Sciences
Bin Bin Wang, Chao Guo, Sheng Qiao Sun, Xing Nan Zhang, Zhen Li, Wei Jie Li, De Zhi Li, Michael Schumacher, Song Liu
Summary: This study compared the effect of different peripheral nerve injury models on nerve regeneration through animal experiments. It was found that the regeneration speed was faster in the crush injury model, while it was slower in the transection injury model. This provides some reference for the selection of clinical research models.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2023)
Article
Engineering, Biomedical
Binghui Jin, Yunru Yu, Xiangxiang Chen, Yanhong Yang, Yushan Xiong, Young Jun Im, Yuanjin Zhao, Jian Xiao
Summary: The study proposes a novel microtube for sciatic nerve regeneration using gradient decellularized porcine sciatic nerve extracellular matrix hydrogel (pDScNM-gel). The pDScNM is shown to enhance cell proliferation and migration, improve axon growth, and these effects can also be achieved through coculture in a gradient pDScNM microtube. In vivo sciatic nerve regeneration and functional recovery are demonstrated by assembling the gradient pDScNM microtubes with a medical silicon tube.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Imran, Ghulam Hussain, Arruje Hameed, Iqra Iftikhar, Muhammad Ibrahim, Rahat Asghar, Izzat Nisar, Tahir Farooq, Tanzila Khalid, Kanwal Rehman, Mohammed A. Assiri
Summary: This study screened the functional metabolites of Moringa oleifera and found that they play an important role in accelerated functional recovery after peripheral nerve injury. The extracts from Moringa showed potential in promoting the recovery of sensory and motor functions, as well as controlling oxidative stress and facilitating nerve regeneration. This study highlights the significance of Moringa as a sustainable source of nutritive metabolites and a valuable target for drug development.
Article
Biochemistry & Molecular Biology
Svetlana Demyanenko, Maria A. Pitinova, Yulia N. Kalyuzhnaya, Andrey M. Khaitin, Svetlana A. Batalshchikova, Natalya M. Dobaeva, Yulia A. Shevtsova, Kirill Goryunov, Egor Y. Plotnikov, Svetlana G. Pashkevich, Gennady T. Sukhikh, Denis N. Silachev
Summary: Peripheral nerve injury is a significant medical problem without effective treatment currently. However, the use of multipotent mesenchymal cells (MSCs)-derived extracellular vesicles (EVs) shows promise in promoting the regeneration of peripheral nerves after injury. In a rat model of sciatic nerve injury, the application of MSCs-EVs gel significantly reduced muscle atrophy and improved functional recovery. The results suggest that this therapeutic approach may be efficient for the treatment of acute peripheral nervous system injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Qunzhou Zhang, Justin C. Burrell, Jincheng Zeng, Faizan Motiwala, Shihong Shi, D. Kacy Cullen, Anh D. Le
Summary: This study generated gingiva-derived mesenchymal stem cell (GMSC)-repopulated nerve protectors and evaluated their therapeutic effects in a crush injury model. The results showed that the Schwann-like cells converted from GMSCs were able to promote functional recovery and axonal regeneration of injured sciatic nerves.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Xuezhen Shen, Feng Qu, Yilun Pei, Simeng Lei, Suhang Xia, Jing Liang, Shan Li, Xun Sun, Liang Liu
Summary: This study demonstrates that the combined application of functionalized self-assembling peptide gels and chitosan nerve conduits accelerates nerve healing and enhances morphological repair, providing a promising therapy for peripheral nerve regeneration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Orthopedics
Chen Yu, Xiaoxu Wang, Jian Qin
Summary: Necrostatin-1 (Nec-1) can reduce peripheral nerve lesions and protect Schwann cells and axons by inhibiting necroptosis. It also reduces inflammation and oxidative stress by inhibiting RIP1.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Acoustics
Shixuan Xu, Akira Ito, Tianshu Wang, Hideki Kawai, Tomoki Aoyama, Hiroshi Kuroki
Summary: The study aims to investigate the effects of ultrasound on the dorsal root ganglion neurons at the injury site in a rat model of sciatic nerve crush injury. The results show that ultrasound therapy promotes nerve regeneration, modulates gene and protein expression, and improves motor function and myelinated fiber density.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Acoustics
Tianshu Wang, Akira Ito, Shixuan Xu, Hideki Kawai, Hiroshi Kuroki, Tomoki Aoyama
Summary: This study demonstrated that low-intensity pulsed ultrasound (LIPUS) can promote functional and histologic improvements in sciatic nerve crush injury in a rat model, with upregulation of BDNF expression.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Almir Jordao da Silva-Junior, Louise Alessandra Mesentier-Louro, Gabriel Nascimento-dos-Santos, Leandro Coelho Teixeira-Pinheiro, Juliana F. Vasques, Luiza Chimeli-Ormonde, Victor Bodart-Santos, Luiza Rachel Pinheiro de Carvalho, Marcelo Felippe Santiago, Rosalia Mendez-Otero
Summary: Human umbilical Wharton's jelly-derived MSCs and their extracellular vesicles showed sustained neuroprotective effects and promoted regeneration of RGCs in a rat model of optic nerve crush. This highlights the potential of cell therapy using human MSCs for neuroprotection and axon regeneration after optic nerve injury.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Zeina Msheik, Stephanie Durand, Emilie Pinault, Martial Caillaud, Laetitia Vignaud, Fabrice Billet, Mohamed El Massry, Alexis Desmouliere
Summary: This study compared the sensorimotor and histological aspects of peripheral neuropathies in two rat models, sciatic nerve crush and Charcot-Marie-Tooth-1A (CMT1A) disease. Protein analysis revealed common pathological pathways between these two diseases and identified potential therapeutic targets.
NEURAL REGENERATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Waleed M. Renno, Mohammad Afzal, Bincy Paul, Divya Nair, Jijin Kumar, Jassim M. Al-Hassan
Summary: Preparations from the epidermal gel secretion of Arabian Gulf catfish showed potent anti-inflammatory and healing properties in clinical trials for diabetic foot ulcers and other disorders. A unique protein and lipid preparation from the catfish secretion accelerated the healing of nerve injuries in rats, enhancing neurobehavioral performance and histomorphological regeneration. SPF-FB treatment decreased neurobehavioral deficits, promoted axonal regeneration, and protected spinal neurons by modulating astrocytic activity and GAP-43 expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Jaquelini Betta Canever, Lais Coan Fontanela, Ketlyn Germann Hendler, Aline Vieceli, Rafael Inacio Barbosa, Heloyse Uliam Kuriki, Aderbal Silva Aguiar Junior, Lais Mara Siqueira das Neves, Marisa de Cassia Registro Fonseca, Alexandre Marcio Marcolino
Summary: The study investigated the effects of PBM and TUS on TRAM viability in mice, with TUS demonstrating greater efficiency in maintaining TRAM viability. PBM 830 nanometers also showed good results in TRAM viability. The skin temperature only showed significant differences in the immediate postoperative period in group 1.
LASERS IN MEDICAL SCIENCE
(2022)
Review
Rehabilitation
Flavia Belavenuto Rangon, Jessica da Silva, Almir Vieira Dibai-Filho, Rinaldo Roberto de Jesus Guirro, Elaine Caldeira de Oliveira Guirro
Summary: This study comprehensively evaluated the effects of complex physical therapy and multimodal approaches on lymphedema secondary to breast cancer. The findings suggest that complex physical therapy has favorable short-term and long-term effects in controlling lymphedema. Future research should aim to determine the specific effects of different therapeutic modalities in different time periods.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Orthopedics
Natalia Claro da Silva, Flavia Pessoni Faleiros Macedo Ricci, Vinicius Restani de Castro, Alessandra Cristina Ramos de Lima, Ester R. do Carmo Lopes, Leonardo Dutra de Salvo Mauad, Karen A. Kawano Suzuki, Maria Eloisa de Oliveira Medeiros, Joyce Silva de Santana, Fernanda Ludmilla Rossi Rocha, Marisa de Cassia Registro Fonseca
Summary: The study aims to evaluate the effectiveness of a specific and individualized workplace strengthening exercise program combined with ergonomic guidance in reducing fatigue, pain, and discomfort in the upper extremities and neck perceived by workers. The study will assess muscle strength, pain scale, and other outcomes to analyze the differences before and after the intervention. The results of this study will provide evidence for the benefit of resistance exercise in facilitating neuro-muscular adaptations and hypertrophy in later phases.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Engineering, Biomedical
Flavia Fernanda de Oliveira Assuncao, Erika Nascimento, Lucas Chaves, Alessandro Marcio Hakme da Silva, Roberto Martinez, Rinaldo Roberto de Jesus Guirro
Summary: The aim of this study was to investigate the inhibitory effects of LED irradiation on Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. The results showed that LED irradiation at different wavelengths and energy densities can effectively inhibit the growth of these bacteria, reducing the colony-forming units.
LASERS IN MEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
Larissa Rodrigues Souto, Malu Siqueira Borges, Alexandre Marcio Marcolino, Fabio Viadanna Serrao, Roberta de Fatima Carreira Moreira Padovez
Summary: This study aims to evaluate the effectiveness of adjunctive treatments plus exercise therapy versus exercise therapy, and determine the relative efficacy of different types of adjunctive treatments plus exercise therapy for individuals with patellofemoral pain.
Article
Rehabilitation
Morgana Martins De Toni, Rafael Silveira Duarte, Lais Mara Siqueira das Neves, Fernando Diefenthaeler, Marisa de Cassia Registro Fonseca, Rafael Inacio Barbosa, Heloyse Uliam Kuriki, Alexandre Marcio Marcolino
Summary: This study aimed to investigate and compare the effects of therapeutic exercise, therapeutic ultrasound, and photobiomodulation on the pain, functionality, and recruitment pattern of motor units in seamstresses with neck pain. The results showed that photobiomodulation and ultrasound had a greater tendency to improve pain, and photobiomodulation had a significant effect on certain muscles.
JOURNAL OF BODYWORK AND MOVEMENT THERAPIES
(2022)
Article
Physiology
Gabriela de Carvalho, Marcelo Papoti, Marcia Caroline Diniz Rodrigues, Yan Figueiredo Foresti, Elaine Caldeira De Oliveira Guirro, Rinaldo Roberto De Jesus Guirro
Summary: This study analyzed the physical performance and self-perceived menstrual symptoms of physically active women with regular menstrual cycles in two phases of the menstrual cycle. The results showed that there was no significant difference in physical performance between the phases, but menstrual flow intensity and perception of cycle interference may affect physical performance.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Orthopedics
Jocassia Silva Pinheiro, Filipe Ramos Carlos, Luis Carlos Caseiro-Filho, Celso Herminio Ferraz Picado, Flavio Luis Garcia, Elaine Caldeira de Oliveira Guirro, Rinaldo Roberto de Jesus Guirro
Summary: The objective of this study was to analyze the bioelectrical impedance parameters of the lower limbs in individuals with hip osteoarthritis and healthy individuals. A cross-sectional study was conducted, and the results showed significant differences in phase angle, impedance, and muscle mass between the affected and unaffected sides in patients with osteoarthritis. It was concluded that segmental electrical bioimpedance equipment can detect differences between limbs affected and unaffected by hip osteoarthritis.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Neurosciences
Marcia Cristina Gomes Costa, Ketlyn Germann Hendler, Heloyse U. Kuriki, Rafael I. Barbosa, Lais Mara S. das Neves, Elaine C. de Oliveira Guirro, Rinaldo R. de Jesus Guirro, Alexandre Marcio Marcolino
Summary: This study aimed to analyze the effect of neoprene orthosis on the balance and functionality of healthy individuals and volunteers with lateral ankle sprains. The results showed that the control group experienced a decrease in ground reaction force and anteroposterior force displacement when using the orthosis, while the patient group experienced an increase in force and moment of medial-lateral displacement. Orthosis had influence on individuals' balance and joint angles.
Article
Anesthesiology
Mariana Rodrigues, Rafael I. Barbosa, Lais M. S. Neves, Heloyse U. Kuriki, Elaine C. D. Goncalves, Adair R. S. Santos, Rafael C. Dutra, Alexandre M. Marcolino
Summary: This study investigated the effects of pulsed and continuous ultrasound on edema and hyperalgesia in a chronic inflammatory process. The results showed that both pulsed and continuous ultrasound reduced paw edema, with pulsed ultrasound having a greater effect. Higher irradiation frequencies were associated with inhibition of edema, while lower frequencies mainly reduced hyperalgesia. The beneficial effects of ultrasound may be attributed to the upregulation of pro-inflammatory and anti-inflammatory cytokines.
BRAZILIAN JOURNAL OF ANESTHESIOLOGY
(2023)
Article
Engineering, Biomedical
Gabriela de Carvalho Rotoly, Marcelo Papoti, Yan Figueiredo Foresti, Elaine Caldeira de Oliveira Guirro, Rinaldo Roberto Jesus Guirro
Summary: This study evaluated the effects of photobiomodulation on the physical performance of healthy women during the follicular phase of the menstrual cycle. Twenty-seven physically active women underwent performance evaluations before and after receiving photobiomodulation therapy or sham therapy. The results showed no significant difference in performance variables between the two groups, indicating that photobiomodulation did not improve muscle performance, resistance to fatigue, perceived exertion, and blood lactate concentrations during an anaerobic test in healthy women during the follicular phase of the menstrual cycle.
LASERS IN MEDICAL SCIENCE
(2023)
Review
Engineering, Biomedical
Aline Santos Vieceli, Juruciara Cristiano Martins, Ketlyn Germann Hendler, Ana Paula Tavares Santos, Lais Mara Siqueira das Neves, Rafael Inacio Barbosa, Heloyse Uliam Kuriki, Alexandre Marcio Marcolino
Summary: This review evaluated the efficacy of photobiomodulation, ultrasound, and high-frequency electrophysical agents in the healing of pressure injuries. The results showed that photobiomodulation had similar efficacy to other technologies in pressure injury healing. Therapeutic ultrasound was effective in reducing the area of pressure injuries. However, no clinical studies using high-frequency electrophysical agents were found in the past 5 years.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Almir Vieira Dibai-Filho, Alessandra Kelly de Oliveira, Matheus Pereira Oliveira, Marilia Artese Barros, Debora Bevilaqua-Grossi, Rinaldo Roberto de Jesus Guirro
Summary: This study aimed to evaluate the intra- and inter-rater reliability of quantitative sensory testing for measuring the thermal pain threshold on myofascial trigger points in individuals with chronic neck pain. The results showed that this testing method has good reliability, supporting its use in both research and clinical settings.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2022)