Article
Nanoscience & Nanotechnology
Jenny Lou, Masato Aragaki, Nicholas Bernards, Tomonari Kinoshita, Jessica Mo, Yamoto Motooka, Tsukasa Ishiwata, Alexander Gregor, Tess Chee, Zhenchian Chen, Juan Chen, Kichizo Kaga, Satoru Wakasa, Gang Zheng, Kazuhiro Yasufuku
Summary: PLP-mediated PDT not only eradicates irradiated tumors but also induces regression of nonirradiated metastases. The treatment shows promise in improving the sensitivity of nonirradiated tumors to therapy.
Article
Chemistry, Multidisciplinary
Zebin Yang, Yu Luo, Huizhu Yu, Kaicheng Liang, Miao Wang, Qigang Wang, Bo Yin, Hangrong Chen
Summary: This study has constructed a novel nanomaterial to reshape the immunosuppressive tumor microenvironment. The nanomaterial can generate reactive oxygen species to alleviate tumor hypoxia and promote the polarization of tumor-associated macrophages. The light-activated nanoplatform can activate and recruit immune cells in combination with radiotherapy, reversing the immunosuppressive tumor microenvironment and enhancing immune responses.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Dan Wang, Hui Li, Dianyu Wang, Yusen Hao, Han Gui, Jianfeng Liu, Yumin Zhang, Jinjian Liu, Cuihong Yang
Summary: A coassembled hydrogel that can cascade release ROS/NO/RNS and strengthen antitumor T cell responses has been developed, which significantly improves the efficacy of immune checkpoint blockade therapy in photodynamic therapy. Reprogramming of tumor-associated macrophages (TAMs) further alleviates the immunosuppressive situation in the tumor microenvironment.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Engineering, Biomedical
Lihua Luo, Xiang Li, Junlei Zhang, Chunqi Zhu, Mengshi Jiang, Zhenyu Luo, Bing Qin, Yanqing Wang, Bin Chen, Yongzhong Du, Yan Lou, Jian You
Summary: Effective tumor vaccine is crucial in boosting immune system to produce more memory T cells, which has great potential for cancer prevention and therapy.
Review
Chemistry, Inorganic & Nuclear
Jianjun Du, Tiancong Shi, Saran Long, Pengzhong Chen, Wen Sun, Jiangli Fan, Xiaojun Peng
Summary: Photodynamic therapy (PDT) is a non-invasive therapy that has attracted increasing interest for treating tumors, but the lack of oxygen in solid tumors limits its effectiveness. The reconstruction of the tumor microenvironment and development of anti-hypoxia photosensitizers are important research topics for improving the efficacy of PDT.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Medicine, Research & Experimental
Min Zhang, Yifan Zhao, He Ma, Yusong Sun, Jie Cao
Summary: Photodynamic therapy (PDT) is a promising method for tumor treatment by inducing immunogenic cell death and local inflammation. However, additional strategies are needed to enhance the immune response against cancer cells.
Article
Engineering, Biomedical
Xiaoge Zhang, Junjie Tang, Chao Li, Yao Lu, Lili Cheng, Jie Liu
Summary: Photo-immunotherapy using black phosphorus nanoparticles modified with hyaluronic acid shows excellent therapeutic efficacy through combined photothermal and photodynamic therapy, remodeling tumor-associated macrophages and inducing immunogenic cell death. The nanoparticles selectively accumulate at the tumor site and induce antitumor immune responses by releasing DAMPs.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Haina Tian, Yang Li, Jinyan Lin, Fukai Zhu, Zhenqing Hou, Peiyuan Wang, Xiaolong Liu
Summary: Researchers have successfully constructed GSH/pH-sensitive Mn2+/polydopamine-incorporated hollow mesoporous tetrasulfide-bridged organosilica nanoreactors loaded with l-arginine (l-Arg). These nanoreactors generate reactive oxygen species (ROS) and nitric oxide (NO) for photothermal-intensified chemodynamic therapy and gas therapy, and enhance the immune response by inducing immunogenic cell death (ICD) and converting macrophages into an M1 phenotype.
ACS MATERIALS LETTERS
(2023)
Article
Engineering, Biomedical
Jenny Lou, Masato Aragaki, Nicholas Bernards, Tess Chee, Alexander Gregor, Yoshihisa Hiraishi, Tsukasa Ishiwata, Chelsea Leung, Lili Ding, Shinsuke Kitazawa, Takamasa Koga, Yuki Sata, Hiroyuki Ogawa, Juan Chen, Tatsuya Kato, Kazuhiro Yasufuku, Gang Zheng
Summary: In combination with immune checkpoint inhibitors, photodynamic therapy can induce robust immune responses capable of preventing local tumor recurrence and delaying the growth of distant, untreated disease. This study investigated the mechanisms behind the abscopal effect induced by photodynamic therapy using porphyrin lipoprotein as a photosensitizer. The addition of an immune checkpoint inhibitor further strengthened the immune response and antigen presentation. However, combination therapy showed mild laboratory tumor lysis syndrome. Overall, this study sheds light on the effectiveness and safety of photodynamic therapy in combination with immune checkpoint inhibitors.
Article
Immunology
Mladen Korbelik
Summary: The main function of whole-cell cancer vaccines is the ingestion of tumor antigen-containing material by the patient's antigen-presenting cells. Blocking specific phagocytic receptors may eliminate the therapeutic efficacy of the vaccine, while blocking certain inhibitory receptors could enhance tumor control by the vaccine. This study establishes a potential strategy for enhancing the therapeutic effects of PDT-generated (and possibly other) whole-cell tumor vaccines.
Review
Oncology
Liuchang Tan, Xiaoxiao Shen, Zhiqiang He, Yuangang Lu
Summary: This paper reviews the tumor treatment strategies of photodynamic therapy (PDT) combined with anti-tumor immunotherapy, focusing on the stimulating effect of PDT on tumor immune response and the mechanisms of enhancing efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rajeev Shrestha, Shyam Kumar Mallik, Junmo Lim, Pallavi Gurung, Til Bahadur Thapa Magar, Yong-Wan Kim
Summary: Photodynamic therapy (PDT) can eliminate cancer cells and induce antitumor immune response by using Chlorin e6 (Ce6). Two efficient synthetic methods for preparing Ce6 from Spirulina platensis were described, and the phototoxic effect of Ce6 was investigated in vitro and its antitumor activity in vivo. The results showed that Ce6-PDT not only suppressed tumor growth at the injection site but also induced antitumor immunity through upregulating the expression of IFN-gamma, TNF-alpha, and IL-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Kexin Li, Huan Yu, Zhihong Bao, Lu Xu, Hong Zhang, Tian Wang, Longyue Yu, Yue Yuan
Summary: The combination of photodynamic therapy and immunotherapy as a new antitumor strategy can improve the effectiveness of tumor treatment by increasing drug concentration, killing tumor cells, promoting immune response, and blocking immune checkpoint pathways.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Materials Science, Multidisciplinary
Xin Li, Yu Zhen, Shanshan Li
Summary: This article reviews the significance of immune checkpoint blockade, photodynamic therapy, and nanotechnology in cancer treatment, highlighting the promising results of their combination in preclinical models and potential clinical applications.
MATERIALS & DESIGN
(2021)
Article
Multidisciplinary Sciences
Huapan Fang, Zhaopei Guo, Jie Chen, Lin Lin, Yingying Hu, Yanhui Li, Huayu Tian, Xuesi Chen
Summary: While immunotherapy has shown promise as a cancer treatment, durable benefits are often limited by immune escape mechanisms. This study combines epigenetic regulation with gene therapy for immune checkpoint blockade to enhance anti-tumor effects and immune responses in vivo, providing a potential strategy for tumor treatment and prevention of relapse and metastasis.
NATURE COMMUNICATIONS
(2021)
