Article
Computer Science, Interdisciplinary Applications
Chun-Mei Feng, Yunlu Yan, Geng Chen, Yong Xu, Ying Hu, Ling Shao, Huazhu Fu
Summary: Accelerated multi-modal magnetic resonance (MR) imaging is a new and effective solution for fast MR imaging. The proposed multi-modal transformer (MTrans) utilizes improved transformers and a cross attention module to capture deep multi-modal features at multiple scales. MTrans outperforms state-of-the-art methods in various accelerated multi-modal MR imaging tasks.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Cell Biology
Svetlana Rodimova, Nikolai Bobrov, Artem Mozherov, Vadim Elagin, Maria Karabut, Ilya Shchechkin, Dmitry Kozlov, Dmitry Krylov, Alena Gavrina, Vladimir Zagainov, Elena Zagaynova, Daria Kuznetsova
Summary: In order to reduce the risk of post-hepatectomy liver failure in patients with hepatic pathologies, a method to assess the liver's regenerative potential during surgery is necessary. Traditional clinical methods are not effective in predicting the function of the liver remnant. Modern label-free bioimaging techniques, such as multiphoton microscopy combined with second harmonic generation and fluorescence lifetime imaging microscopy, can provide insights into liver pathologies and regenerative potential. By using these techniques, we were able to identify markers for impaired regenerative potential and metabolic changes in pathological liver tissue.
Article
Chemistry, Analytical
Hawzhin Hozhabr Pour, Frederic Li, Lukas Wegmeth, Christian Trense, Rafal Doniec, Marcin Grzegorzek, Roland Wismueller
Summary: Identifying accident patterns in driving analysis is crucial for environmental, safety, and fleet management applications. Automated accident detection based on machine learning with in-car sensors shows promising results, especially utilizing CNN features with SVM classifiers. The fusion experiment of feature engineering and feature learning approaches can efficiently enhance performance.
Article
Chemistry, Multidisciplinary
Xu Han, Xiaoli Zhao, Tao Zeng, Yahan Yang, Hongyan Yu, Cong Zhang, Bin Wang, Xiaoqian Liu, Tao Zhang, Jing Sun, Xinyuan Li, Tuo Zhao, Mingxin Zhang, Yanping Ni, Yanhong Tong, Qingxin Tang, Yichun Liu
Summary: This paper presents a multimodal-synergistic-modulation neuromorphic imaging system based on ultraflexible synaptic transistors, which successfully simulates dry eye imaging behavior and important functions of the human visual system. It simplifies the complexity of traditional neuromorphic visual systems and plays a positive role in biomedical eye care.
Article
Optics
Angel Cifuentes, Tomas Pikalek, Petra Ondrackova, Rodrigo Amezcua-Correa, Jose Enrique Antonio-Lopez, Tomas Cizmar, Johanna Tragardh
Summary: This study demonstrates label-free second-harmonic generation (SHG) microscopy using a multimode fiber-based endoscope, enabling polarization-resolved imaging of structural proteins in tissue at depths beyond the reach of multiphoton imaging. The method shows promise for instant and in situ diagnosis of tumors and fibrotic conditions with minimal damage.
Article
Optics
Chun-Yu Cho, Jui-Yu Lai, Chen-Shao Hsu, Yu-Tai Huang, Jeng-Han Jang, Ming-Hsien Chou
Summary: The power scaling of continuous-wave second harmonic generation in a MgO:PPLN ridge waveguide was investigated in this study, confirming the nonlinear coefficient and propagation loss factors of the waveguide. By utilizing the designed waveguide structure, high conversion efficiency for 775nm SHG power was successfully achieved.
Article
Computer Science, Interdisciplinary Applications
Weikang Gong, Song Bai, Ying-Qiu Zheng, Stephen M. Smith, Christian F. Beckmann
Summary: The data-driven discovery of image-derived phenotypes (IDPs) has great potential for neuroscientific and clinical research, as it links IDPs to subjects' demographic, behavioral, clinical, and cognitive measures. However, current approaches lack integration with non-imaging derived phenotypes (nIDPs). In this paper, a semi-supervised, multimodal, and multi-task fusion approach called SuperBigFLICA was proposed, which incorporates information from multiple imaging modalities and nIDPs. The algorithm was shown to enhance the prediction power of nIDPs and derive biologically meaningful IDPs.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Review
Chemistry, Multidisciplinary
Janasik Dawid, Tomasz Krawczyk
Summary: This review discusses the application of multimodal F-19 MRI probes in combination with various imaging techniques, highlighting their ability to compensate for the limitations of individual techniques and improve detection sensitivity and accuracy. Strategies for designing F-19 MRI multimodal probes are also described.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Dawid Janasik, Tomasz Krawczyk
Summary: This review discusses the development of F-19 MRI multimodal probes in combination with various imaging techniques, highlighting how they compensate for deficiencies in individual techniques and improve sensitivity and accuracy of detection. Strategies for designing these probes focus on structure, physicochemical properties, biocompatibility, and image quality.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Elen Tolstik, Nairveen Ali, Shuxia Guo, Paul Ebersbach, Dorothe Moellmann, Paula Arias-Loza, Johann Dierks, Irina Schuler, Erik Freier, Joerg Debus, Hideo A. Baba, Peter Nordbeck, Thomas Bocklitz, Kristina Lorenz
Summary: Vibrational spectroscopy, particularly CARS imaging, shows promise in diagnosing diseases like Fabry disease by detecting biomolecular shifts. The combination of CARS and multivariate data analysis allows for reliable differentiation between disease and control groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Optics
M. S. Pochechuev, A. A. Lanin, I. Kelmanson, A. S. Chebotarev, E. S. Fetisova, D. S. Bilan, E. K. Shevchenko, A. A. Ivanov, A. B. Fedotov, V. V. Belousov, A. M. Zheltikov
Summary: Multimodal nonlinear microscopy combining third-harmonic generation (THG) with two- and three-photon excited fluorescence (2PEF and 3PEF) provides a powerful resource for high-fidelity imaging of nucleoli and nucleolar proteins. With a suitably tailored genetically encoded fluorescent stain, reliable detection of specific nucleolar proteins' 2PEF/3PEF readout against extranucleolar signal enables high-contrast imaging. THG offers a versatile readout for imaging unstained nucleoli in various biological systems, from neurons in brain slices to cultured HeLa cells.
Review
Radiology, Nuclear Medicine & Medical Imaging
Juan Quesada, Kirsi Harma, Shannon Reid, Tanushree Rao, Glen Lo, Natalie Yang, Sonal Karia, Emmeline Lee, Nira Borok
Summary: Endometriosis is a chronic inflammatory disorder characterized by the presence of endometrial-like tissue outside of the uterus. It affects approximately 10% of reproductive age women and is associated with abdomino-pelvic pain, infertility, and other non-gynecologic symptoms. Diagnosing endometriosis can be challenging, despite the development of several guidelines. Transvaginal ultrasound is the recommended imaging modality for identifying endometriosis, while MRI provides complementary information for surgical planning and has high reproducibility.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Marcus E. Graziotto, Clinton J. Kidman, Liam D. Adair, Simon A. James, Hugh H. Harris, Elizabeth J. New
Summary: This article introduces the study of cellular systems using multimodal imaging techniques, focusing on the combination of optical fluorescence microscopy and X-ray fluorescence microscopy. The use of this technique broadens the scope of biological models and has the potential to uncover previously unknown knowledge about disease states.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Biochemical Research Methods
Duanyang Xu, Sijing Liang, Lin Xu, Konstantinos N. Bourdakos, Peter Johnson, James Read, Jonathan H. V. Price, Sumeet Mahajan, David J. Richardson
Summary: The study showcases a continuous wave seeded synchronization-free optical parametric amplifier (OPA) with high performance in CARS, SHG, and two-photon fluorescence microscopy, making it a promising tool for biomedical imaging research. The OPA offers simplified setup and rapid tuning capabilities, enabling label-free multiphoton microscopy techniques for potential translation into a diagnostic tool in healthcare settings.
BIOMEDICAL OPTICS EXPRESS
(2021)
Review
Chemistry, Multidisciplinary
Yuqi Wang, Yuxuan Hu, Deju Ye
Summary: Multimodal imaging, combining multiple imaging modalities, has become a powerful tool in biomedical research and clinical diagnosis. Activatable multimodal probes, which can generate signal switches in different imaging modalities, have shown great potential for in vivo imaging. This Minireview summarizes recent progress in the design, activation mechanism, and biomedical applications of activatable multimodal probes, and discusses current challenges and future development perspectives.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Medicine, Research & Experimental
Barbara Schaarschmidt, Sebastian Vlaic, Anna Medyukhina, Sophie Neugebauer, Sandor Nietzsche, Falk A. Gonnert, Juergen Roedel, Mervyn Singer, Michael Kiehntopf, Marc Thilo Figge, Ilse D. Jacobsen, Michael Bauer, Adrian T. Press
Article
Immunology
Sophie Dennhardt, Wiebke Pirschel, Bianka Wissuwa, Christoph Daniel, Florian Gunzer, Sandro Lindig, Anna Medyukhina, Michael Kiehntopf, Wolfram W. Rudolph, Peter F. Zipfel, Matthias Gunzer, Marc Thilo Figge, Kerstin Amann, Sina M. Coldewey
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Engineering, Biomedical
Michelle Maurer, Mark S. Gresnigt, Antonia Last, Tony Wollny, Florian Berlinghof, Rebecca Pospich, Zoltan Cseresnyes, Anna Medyukhina, Katja Graf, Marko Groeger, Martin Raasch, Fatina Siwczak, Sandor Nietzsche, Ilse D. Jacobsen, Marc Thilo Figge, Bernhard Hube, Otmar Huber, Alexander S. Mosig
Article
Biochemical Research Methods
Anna Medyukhina, Marc Thilo Figge
JOURNAL OF BIOPHOTONICS
(2020)
Article
Microbiology
Iordana A. Shopova, Ivan Belyaev, Prasad Dasari, Susanne Jahreis, Maria C. Stroe, Zoltan Cseresnyes, Ann-Kathrin Zimmermann, Anna Medyukhina, Carl-Magnus Svensson, Thomas Krueger, Viktoria Szeifert, Sandor Nietzsche, Theresia Conrad, Matthew G. Blango, Olaf Kniemeyer, Marie von Lilienfeld-Toal, Peter F. Zipfel, Erzsebet Ligeti, Marc Thilo Figge, Axel A. Brakhage
Article
Multidisciplinary Sciences
Anna Medyukhina, Marco Blickensdorf, Zoltan Cseresnyes, Nora Ruef, Jens V. Stein, Marc Thilo Figge
SCIENTIFIC REPORTS
(2020)
Article
Biotechnology & Applied Microbiology
Oliver Sommerfeld, Anna Medyukhina, Sophie Neugebauer, Mohamed Ghait, Svenja Ulferts, Amelie Lupp, Rainer Koning, Reinhard Wetzker, Stefan Schulz, Marc Thilo Figge, Michael Bauer, Adrian T. Press
Summary: In a murine sepsis model, C5ar1-deficient mice show increased survival rates with improved pathogen clearance and preserved liver function. These mice exhibit increased production of the pro-inflammatory mediator IFN-γ and decreased production of the anti-inflammatory cytokine IL-10.
Article
Biochemical Research Methods
Ivan Belyaev, Jan-Philipp Praetorius, Anna Medyukhina, Marc Thilo Figge
Summary: In biomedical research, automated and quantitative analysis of cell migration and interactions is crucial. A new segmentation method for label-free cells has been developed to overcome the interference caused by fluorescent labels. A novel cluster detection and splitting method based on monitoring cell fusion and fission events provides accurate tracking of transient clusters. With this revised version, the quantitative analysis of cell migration is significantly faster, allowing processing of video data at higher resolutions.
Article
Computer Science, Software Engineering
Ruman Gerst, Anna Medyukhina, Marc Thilo Figge
Meeting Abstract
Immunology
J. Dudeck, A. Medyukhina, J. Kotrba, J. Froebel, M. T. Figge, A. Dudeck
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Infectious Diseases
P. Martinac, A. T. Press, A. Medyukhina, J. Benecke, J. Shi, D. Taeuber, S. Hoeppener, Z. Cseresnyes, I Scheblykin, M. H. Graeler, I Rubio, M. T. Figge, U. S. Schubert, M. Bauer
Article
Multidisciplinary Sciences
Naim Al-Zaben, Anna Medyukhina, Stefanie Dietrich, Alessandra Marolda, Kerstin Huenniger, Oliver Kurzai, Marc Thilo Figge
SCIENTIFIC REPORTS
(2019)
Meeting Abstract
Dermatology
I. Shopova, P. Dasari, I. Belyaev, S. Jahreis, Z. Cseresnyes, A. Medyukhina, C. M. Svensson, T. Krueger, V. Szeifert, S. Nietzsche, T. Conrad, J. Linde, O. Kniemeyer, M. von Lilienfeld-Toal, P. Zipfel, E. Ligeti, M. T. Figge, A. Brakhage
Meeting Abstract
Immunology
J. Dudeck, A. Medyukhina, J. Froebel, J. Kotrba, M. T. Figge, A. Dudeck
EUROPEAN JOURNAL OF IMMUNOLOGY
(2018)
Review
Biochemical Research Methods
Carl-Magnus Svensson, Anna Medyukhina, Ivan Belyaev, Naim Al-Zaben, Marc Thilo Figge
