期刊
LASER PHYSICS LETTERS
卷 7, 期 7, 页码 544-548出版社
IOP PUBLISHING LTD
DOI: 10.1002/lapl.201010008
关键词
photodynamic action; LED; pheophorbide a; colon cancer; cellular destruction; apoptosis
资金
- Chinese University of Hong Kong [2030391]
- National Nature Science Foundation of China [30973168]
Pheophorbide a (Pa) from Chinese herbal medicine Scutellaria Barbata and Silkworm Excreta shows an important promise in the photodynamic therapy on malignant tumor. The present study investigated that LED-activated Pa induced the cellular destruction of colon cancer HT-29 cells. The results showed that Pa resulted in a drug-dose dependent photocytotoxicity in the HT-29 cells, meaning the photocytotoxicity of Pa depends on the drug concentration (0-2 mu M). We further investigated the apoptosis of the HT-29 cells 18 hours after photosensitization of Pa using a confocal laser scanning microscopy with Hoechst 33258 staining. These data demonstrated that LED-activated Pa could significantly induce the cellular destruction of the HT-29 cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据