Review
Multidisciplinary Sciences
Amanda J. Krause, Erin H. Walsh, Philip A. Weissbrod, Tiffany H. Taft, Rena Yadlapati
Summary: Laryngopharyngeal reflux (LPR) is a syndrome caused by the reflux of gastric contents into the pharynx or larynx, leading to a variety of symptoms. Treatment options for LPR include medical therapies such as proton pump inhibitors and noninvasive treatment options like lifestyle therapy. Due to the complexity of patients with LPR, a treatment algorithm is proposed to assist clinicians in diagnosing and treating patients effectively.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Joan W. Chen, Marcelo F. Vela, Kathryn A. Peterson, Dustin A. Carlson
Summary: This article provides practical advice for the clinical management of patients with suspected extraesophageal gastroesophageal reflux disease. The advice is based on available evidence from published studies, clinical trials, and clinical guidelines. It emphasizes the importance of considering extraesophageal manifestations of gastroesophageal reflux disease and the need for a multidisciplinary approach in diagnosis and treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Yung-An Tsou, Sheng-Hwa Chen, Wen-Chieh Wu, Ming-Hsui Tsai, David Bassa, Liang-Chun Shih, Wen-Dien Chang
Summary: This study investigated the clinical assessments and extent of esophageal pressure changes in LRPD patients with varying severities of GERD. It found that patients with more severe GERD had lower esophageal sphincter pressures, with the lowest pressures observed in patients with grade D GERD. No significant differences in esophageal pressures were noted based on age, gender, or BMI among the patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Otorhinolaryngology
Gui Chen, Weixing Liu, Wenjing Liao, Lijuan Song, Pingchang Yang, Xiaowen Zhang
Summary: This study found high detection rates of GERD and LPRD at the digestive endoscopy center in Guangzhou, China. Older age, BMI >= 24.0 kg/m(2), smoking, and drinking history were identified as risk factors for both GERD and LPRD. Neither GerdQ nor RSI scores included common extraesophageal symptoms.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Medicine, General & Internal
Gaia Pellegatta, Benedetto Mangiavillano, Rossella Semeraro, Francesco Auriemma, Elisa Carlani, Alessandro Fugazza, Edoardo Vespa, Alessandro Repici
Summary: Extraesophageal reflux symptoms are common in the Western population and their clinical management is controversial. This study evaluated a new treatment method for patients with GERD experiencing extraesophageal symptoms. The results showed that the treatment method reduced symptom frequency and severity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Afrin N. Kamal, Shumon Dhar, Jonathan M. Bock, John O. Clarke, Jerome R. Lechien, Jacqueline Allen, Peter C. Belafsky, Joel H. Blumin, Walter W. Chan, Ronnie Fass, P. Marco Fisichella, Michael Marohn, Ashli K. O'Rourke, Gregory Postma, Edoardo Savarino, Michael F. Vaezi, Thomas L. Carroll, Lee M. Akst
Summary: Best practice statements for the treatment of LPR were identified using a well-tested methodology. These statements serve as a guide for physicians in making treatment decisions for LPR.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Review
Medicine, General & Internal
Valentinos Sofokleous, Anna-Maria Papadopoulou, Evangelos Giotakis, Alexander Delides, Efthymios Kyrodimos, Pavlos Maragoudakis, Ioannis Psarommatis
Summary: This study reviews the latest developments in pediatric laryngopharyngeal reflux, highlighting the need for further research on diagnostic methods and treatment strategies. The review includes 86 articles and emphasizes the urgency of future studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
S. E. Aragona, M. E. Baldassarre, S. Lazzaro, G. Ciprandi
Summary: Gastric reflux, such as GERD, has seen an increasing prevalence worldwide. The guidelines for diagnosing and treating GERD have been well consolidated and frequently updated. Extra-esophageal manifestations of reflux, such as LPR, have been considered from a multidisciplinary perspective. However, treatment options for LPR are still poorly specified.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Medicine, General & Internal
Zihao Guo, Jiali Jiang, Hao Wu, Jinxia Zhu, Shutian Zhang, Chuan Zhang
Summary: Peptest shows moderate diagnostic value for LPR and GERD, but more studies with standard protocols are needed to verify its effectiveness.
Article
Pediatrics
Rachel Rosen, Reza Rahbar, Karen Watters, Anne Hseu, Carlos J. Munoz, Lynne Ferrari, Robert Holzman, Shoaib Mohammad, Alexandra Cohen, Maritha Du, Anna Akkara, Andrea Catacora, Tregony Simoneau, Sarah Connearney, Paul Mitchell, Samuel Nurko
Summary: The objective of this study was to validate a novel biomarker, airway impedance, for extraesophageal disease. The study recruited patients with respiratory symptoms and performed endoscopy and direct laryngoscopy. The results showed no significant correlation between airway impedance and reflux scores, but patients with aspiration had lower airway impedance. Therefore, airway impedance may be an important tool for diagnosing gastroesophageal reflux or aspiration.
JOURNAL OF PEDIATRICS
(2023)
Article
Otorhinolaryngology
Yu Zhao, Honglei Han, Qiuping Lu, Yan Liang
Summary: This study retrospectively analyzed the clinical data of GERD patients with chronic cough and found that these patients commonly exhibited symptoms and signs of laryngopharyngeal reflux, with most of them having abnormal RSI and/or RFS. Some of the patients experienced laryngopharyngeal reflux episodes in the upright position.
ENT-EAR NOSE & THROAT JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Sydney R. A. Korsunsky, Leonel Camejo, Diep Nguyen, Rahul Mhaskar, Khattiya Chharath, Joy Gaziano, Joel Richter, Vic Velanovich
Summary: This study retrospectively analyzed the clinical evaluation, treatments, and outcomes of patients with hoarseness suspected to be caused by laryngopharyngeal reflux. Among the 134 included patients, most of them experienced improvement during the treatment and evaluation period, but no specific treatment type showed a clear association with the outcomes. Further research is needed to explore diagnostic criteria, efficient clinical evaluation methods, and potential beneficial treatments for laryngopharyngeal reflux.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Otorhinolaryngology
Michael Zhang, Clemente Chia, Claire Stanley, Debra J. Phyland, Paul M. Paddle
Summary: Salivary pepsin detection shows high sensitivity and positive predictive value in diagnosing laryngopharyngeal reflux. Superior specificity and positive predictive value can be achieved by raising thresholds and conducting symptomatic testing.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Endocrinology & Metabolism
S. E. Aragona, G. Ciprandi
Summary: Gastroesophageal reflux disease (GERD) is a common condition in the Western population and the most frequent reason for gastroenterology consultation. Pharmacists play a crucial role in advising on the management of GERD, and their knowledge update significantly affects their recommendations. Proton pump inhibitors (PPIs) and alginates are commonly used medications, with combined therapy being the most common approach.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Medicine, General & Internal
Karol Zelenik, Viktoria Hrankova, Adela Vrtkova, Lucia Stanikova, Pavel Kominek, Martin Formanek
Summary: The study investigates the diagnostic value of Peptest in detecting LPR based on MII-pH monitoring. The accuracy for diagnosing LPR using Peptest is relatively low, but higher for diagnosing GERD.
JOURNAL OF CLINICAL MEDICINE
(2021)