Article
Oncology
Dorian Culie, Julien Viotti, Anouchka Modesto, Renaud Schiappa, Emmanuel Chamorey, Olivier Dassonville, Gilles Poissonnet, Bruno Guelfucci, Alain Bizeau, Sebastien Vergez, Agnes Dupret-Bories, Renaud Garrel, Nicolas Fakhry, Laure Santini, Benjamin Lallemant, Guillaume Chambon, Anne Sudaka, Frederic Peyrade, Esma Saada-Bouzid, Karen Benezery, Florence Jourdan-Soulier, Francoise Chapel, Anne Sophie Ramay, Pascal Roger, Thibault Galissier, Valerie Coste, Aicha Ben Lakdar, Joanne Guerlain, Stephane Temam, Haitham Mirghani, Phillipe Gorphe, Alexandre Bozec
Summary: Therapeutic strategies significantly impact the oncologic outcomes of patients with p16-negative OPSCC, with primary surgical treatment associated with improved overall survival, disease-specific survival, and recurrence-free survival, particularly in advanced stage tumors.
Article
Oncology
Pihla Pakkanen, Heikki Irjala, Taru Ilmarinen, Elina Halme, Paula Lindholm, Antti Makitie, Tuija Wigren, Leena-Maija Aaltonen
Summary: This study compared the outcomes of transoral laser surgery (TLS) and radiation therapy (RT) in patients with glottic T1a laryngeal squamous cell carcinoma (LSCC). The study found that the oncological outcomes of both treatment modalities were similar.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Dorian Culie, Renaud Schiappa, Anouchka Modesto, Julien Viotti, Emmanuel Chamorey, Olivier Dassonville, Gilles Poissonnet, Alain Bizeau, Sebastien Vergez, Agnes Dupret-Bories, Nicolas Fakhry, Laure Santini, Benjamin Lallemant, Guillaume Chambon, Anne Sudaka, Frederic Peyrade, Esma Saada-Bouzid, Karen Benezery, Florence Jourdan-Soulier, Francoise Chapel, Anne Sophie Ramay, Pascal Roger, Thibault Galissier, Valerie Coste, Aicha Ben Lakdar, Joanne Guerlain, Haitham Mirghani, Phillipe Gorphe, Bruno Guelfucci, Renaud Garrel, Stephane Temam, Alexandre Bozec
Summary: This study aimed to evaluate the impact of initial therapeutic strategy on oncologic outcomes in patients with HPV-positive oropharyngeal squamous cell carcinoma. The results showed that surgical strategy demonstrated significant differences in disease-specific and recurrence-free survival compared to non-surgical strategy, especially after multivariate analysis.
Article
Oncology
Pernille Lassen, Shao Hui Huang, Jie Su, John Waldron, Maria Andersen, Hanne Primdahl, Jorgen Johansen, Claus Andrup Kristensen, Elo Andersen, Jesper Grau Eriksen, Christian Ronn Hansen, Jan Alsner, Jacob Lilja-Fisher, Scott Bratman, Jolie Ringash, John Kim, Andrew Hope, Anna Spreafico, John de Almeida, Wei Xu, Brian O'Sullivan, Jens Overgaard
Summary: Two large-scale HPV+ OPC cohorts treated contemporaneously with similar approaches demonstrated exemplary outcomes, with concurrent chemotherapy being a strong independent prognostic factor for all endpoints, emphasizing the need for careful de-intensification of treatment.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Nanda Horeweg, Remi A. Nout, Ina M. Jurgenliemk-Schulz, Ludy C. H. W. Lutgens, Jan J. Jobsen, Marie A. D. Haverkort, Jan Willem M. Mens, Annerie Slot, Bastiaan G. Wortman, Stephanie M. de Boer, Ellen Stelloo, Karen W. Verhoeven-Adema, Hein Putter, Vincent T. H. B. M. Smit, Tjalling Bosse, Carien L. Creutzberg
Summary: The molecular classification of endometrial cancer has predictive value for response to radiotherapy in early-stage endometrioid EC. Different molecular subtypes have different responses to adjuvant therapy, and radiotherapy may not be necessary for certain molecular subtypes.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Vera Wolters, Joosje Heimovaara, Charlotte Maggen, Elyce Cardonick, Ingrid Boere, Liesbeth Lenaerts, Frederic Amant
Summary: With the increasing incidence of cancer in pregnancy, there is a growing focus on protecting the fetus while ensuring optimal treatment for the mother. Involvement of a multidisciplinary team is crucial for the best possible outcome for both mother and child.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Gemma G. Kenter, Stefano Greggi, Ignace Vergote, Dionyssios Katsaros, Juliusz Kobierski, Heleen van Doorn, Fabio Landoni, Jacobus van der Velden, Nicholas Reed, Corneel Coens, Iske van Luijk, Nicoletta Colombo, Elzbietta van der Steen-Banasik, Nelleke Ottevanger, Antonio Casado
Summary: This trial compared the efficacy of neoadjuvant chemotherapy followed by surgery with concomitant chemoradiation in patients with stage Ib2-IIB cervical cancer. The results showed no significant difference in the 5-year overall survival rate between the two treatment arms.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Otorhinolaryngology
Charles Hurel, Florent Carsuzaa, Julia Salleron, Philippe Gorphe, Christian Righini, Maximilien Roge, Erwan de Mones, Sylvain Moriniere, Sebastien Vergez, Juliette Thariat, Xavier Dufour
Summary: The study aimed to investigate the impact of HPV status on oncologic outcomes in patients with T1-2 oropharyngeal SCC associated with bulky N3 nodes and determine progression prognosis factors for defining optimal therapeutic strategies. The study found that HPV-positive patients without a smoking history had better overall survival (OS) and progression-free survival (PFS) compared to HPV-positive patients with a smoking history and HPV-negative patients.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Laurence Bauwens, Aline Baltres, Danny-Joe Fiani, Philippe Zrounba, Guillaume Buiret, Bertrand Fleury, Nazim Benzerdjeb, Vincent Gregoire
Summary: The study aimed to compare the prevalence and distribution of neck node metastases in HPV+ and HPV- oropharyngeal squamous cell carcinoma patients, showing a higher rate of metastases in the HPV+ group.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Oncology
Chao Yu, Jie Yao, Yujing He, Jianing Huang, Meiling Chen, Mingxia Qian, Dandi Lou, Zhizhen Zhou, Feng Chen
Summary: This study compared the health-related quality of life (HRQoL) of patients with localized prostate cancer (LPCa) after surgery and radiotherapy (RT). The results showed that surgery was associated with better bowel scores, while RT was associated with higher urinary and sexual scores. The difference between surgery and RT decreased over time.
Article
Otorhinolaryngology
Erika M. Stephens, Karolina Plonowska-Hirschfeld, Arushi Gulati, Sagar Kansara, Jesse Qualliotine, Aaron L. Zelbolsky, Annemieke van Zante, Patrick K. Ha, Chase M. Heaton, William R. Ryan
Summary: The purpose of this study was to evaluate changes in patient-reported quality of life (QOL) for HPV+ OPSCC patients and inform treatment decisions. The results showed that most patients had a high QOL post-treatment, with only a few experiencing mild taste and smell dysfunction. Surgery alone offers favorable QOL outcomes for HPV + OPSCC patients.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Medicine, General & Internal
Urszula Kacorzyk, Marek Kentnowski, Cezary Szymczyk, Ewa Chmielik, Barbara Bobek-Billewicz, Krzysztof Skladowski, Tomasz Wojciech Rutkowski
Summary: This study reports the treatment experience of 61 patients with non-squamous cell carcinoma-related malignant sinonasal tract tumors (non-SCC MSTT), showing that salvage is possible in most patients with locoregional failure and significantly prolongs overall survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Otorhinolaryngology
Olaf M. Neve, Jeroen C. Jansen, Radboud W. Koot, Mischa de Ridder, Peter Paul G. van Benthem, Anne M. Stiggelbout, Erik F. Hensen
Summary: This study assessed the long-term quality of life (QoL) of patients with vestibular schwannoma in relation to treatment modality and decisional regret. The results showed that the long-term QoL was comparable for patients under active surveillance and those who received active treatment, and it remained stable over time. This suggests that, on average, preservation of QoL of patients with vestibular schwannoma is feasible when adequately managed.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Dong-Yun Kim, Hong-Gyun Wu, Jin Ho Kim, Joo Ho Lee, Soon-Hyun Ahn, Eun-Jae Chung, Keun-Yong Eom, Young Ho Jung, Woo-Jin Jeong, Tack-Kyun Kwon, Suzy Kim, Chan Woo Wee
Summary: This study compared the outcomes of primary radiotherapy and surgery in early-stage hpv+OPC patients. The results showed no differences in overall survival, progression-free survival, and locoregional control between upfront radiotherapy and surgery in stage I-II hpv+OPC. However, most early-stage hpv+OPC patients undergoing surgery received adjuvant (concurrent chemo)radiotherapy.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Angela M. Hong, Jonathan R. Stretch, John F. Thompson
Summary: For localised Merkel cell carcinoma, the standard treatment is surgical excision followed by radiotherapy. However, for locally advanced MCC, radiotherapy may be an alternative option with up to 90% complete control achievable, and it is generally less morbid than surgery.