Article
Radiology, Nuclear Medicine & Medical Imaging
Paola Feraco, Silvia Piccinini, Cesare Gagliardo
Summary: The correct diagnosis of inner ear malformations is crucial for the management of patients. High-resolution MRI and HRCT are main imaging techniques, but in cases of congenital malformations, these techniques should be considered complementary.
Article
Public, Environmental & Occupational Health
Wei-Jun Yu, Na Li, Ting-Ting Gong, Jia-Yu Zhang, Yu-Ting Jiang, Yu-Hong Zhao, Yan-Hong Huang, Jing Li, Shu Liu, Yan-Ling Chen, Li-Li Li, Cheng-Zhi Jiang, Zong-Jiao Chen, Qi-Jun Wu
Summary: The study found that maternal exposure to sulfur dioxide (SO2) was associated with an increased risk of congenital ear malformations in offspring, especially during the 3 months before and after conception.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2022)
Review
Pediatrics
Davide Brotto, Marzia Ariano, Mose Sozzi, Roberta Cenedese, Eva Muraro, Flavia Sorrentino, Patrizia Trevisi
Summary: About 20% of children with congenital hearing loss have malformations of the inner ear. The morphology and function of the anterior part of the labyrinth have been extensively studied, as hearing loss can significantly impact a child's overall development. While a chance for hearing rehabilitation is now available for most of them, the anomalies range from lack of inner ear development to specific isolated structures. However, little is known about vestibular anomalies and dysfunctions in children with inner ear malformations.
FRONTIERS IN PEDIATRICS
(2023)
Review
Pharmacology & Pharmacy
Derek S. Delaney, Lawrence J. Liew, Joey Lye, Marcus D. Atlas, Elaine Y. M. Wong
Summary: Despite progress in the development of therapeutics for hearing loss, drug delivery to the middle and inner ear remains challenging. Localized delivery and controlled release therapeutics are emerging as potential solutions, but invasive procedures limit continuous drug delivery. This review discusses the challenges in drug development for hearing disorders and explores novel drug delivery approaches, including hydrogel and nanotechnology-based therapeutics and device-mediated delivery methods.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Tabita M. Breitsprecher, Alexander Pscheidl, David Bachinger, Stefan Volkenstein, Anandhan Dhanasingh, Vincent Van Rompaey, Robert Mlynski, Stefan Dazert, Paul Van de Heyning, Sonke Langner, Peter Roland, Nora M. Weiss
Summary: This study evaluates the volumes of the cochlea and vestibular system in different types of Inner Ear Malformations (IEMs) and finds that quantitative reference values for IEM obtained in this study were consistent with existing qualitative diagnostic characteristics. A cutoff value of less than 60 mm(3) for cochlear volume may indicate an abnormally small cochlea. Normal reference values for volumes of the cochlea and vestibular system may aid in diagnosing IEM.
OTOLOGY & NEUROTOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Farideh Moeinvaziri, Ibrahim Zarkesh, Paria Pooyan, Desmond A. Nunez, Hossein Baharvand
Summary: The inner ear is a complex organ that encodes sound, motion, and orientation in space, with its blood supply playing a pivotal role in growth, maturation, and survival of inner ear tissues. Inner ear organoid models are a promising tool to advance the study of multiple aspects of the inner ear to aid the development of new treatments.
Article
Obstetrics & Gynecology
Y. M. Jung, S. M. Lee, S. Oh, S. H. Lyoo, C-W Park, S. D. Lee, J. S. Park, J. K. Jun
Summary: This study aimed to examine the concordance rate of non-chromosomal congenital malformations in twin pairs and found that monozygotic twins had higher concordance rates than dizygotic twins in specific organ systems, particularly in the nervous system, circulatory system, cleft lip/palate, and urinary system.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Cell Biology
Mona Mozaffari, Robert Nash, Abigail S. Tucker
Summary: The mammalian ear is comprised of three parts (the outer, middle, and inner ear) that work together to transmit sound waves into neuronal signals for perception. The outer ear canal, often overlooked in discussions on hearing, plays a crucial role in funneling sound waves to the eardrum and middle ear, and defects in its development can lead to hearing loss. Recent studies have shed light on the complex system of outer ear canal development and its implications for congenital ear canal anomalies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Audiology & Speech-Language Pathology
Emilien Chebib, Audrey Maudoux, Charlotte Benoit, Sophie Bernard, Thierry Van den Abbeele, Natacha Teissier, Sylvette R. Wiener Vacher
Summary: This study investigated the impact of congenital cytomegalovirus infection on cochlear and vestibular function. The results showed that the vestibular part is more often impaired than the cochlear part, emphasizing the importance of evaluating both vestibular and auditory function in children infected with cytomegalovirus.
Article
Otorhinolaryngology
Aysun Parlak Kocabay, Merve Ozbal Batuk, Gonca Sennaroglu, Levent Sennaroglu
Summary: The study aimed to evaluate binaural auditory skills in bimodal and bilateral pediatric cochlear implant (CI) users with incomplete partition type-II (IP-II) and compare the results to pediatric CI users with normal cochlear morphology. The results revealed that bilateral and bimodal pediatric CI users with IP-II benefited from implantation as much as bilateral users with normal anatomy. The differences in residual hearing between groups may explain the poor performance of bimodal users with normal cochlear morphology.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Agronomy
Alexis Carlier, Sebastien Dandrifosse, Benjamin Dumont, Benoit Mercatoris
Summary: This paper proposes an easy and robust method to segment wheat ears from heading to maturity growth stage. The method is based on superpixel classification using features from RGB and multispectral cameras. The results show variations in the segmentation of ears based on different growth stages and nitrogen fertilizer levels.
Article
Pediatrics
Emilien Chebib, Christelle Vauloup-Fellous, Charlotte Benoit, Nathalie Noel Petroff, Thierry Van den Abbeele, Audrey Maudoux, Natacha Teissier
Summary: This monocentric prospective study evaluated the diagnostic performance of cytomegalovirus (CMV) polymerase chain reaction (PCR) on inner ear fluid collected during cochlear implantation and assessed its interest in current practice. The results showed that the CMV PCR on inner ear fluid had a certain sensitivity and specificity in diagnosing CMV-related hearing loss. Additionally, the study found that the sensitivity decreased with age.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Clinical Neurology
Martin A. A. Lewis, Amy Juliano, Caroline Robson, Emma Clement, Robert Nash, Kaukab Rajput, Felice D'Arco
Summary: This study reviewed the genotypes and imaging appearances of cochleae in CHARGE patients, providing a detailed anatomical description and grading system of cochlear anomalies. The goal was to gain insight into the spectrum of cochlear anomalies in CHARGE syndrome and the role of the CHD7 gene in otic vesicle development.
Article
Computer Science, Artificial Intelligence
Amir Benzaoui, Yacine Khaldi, Rafik Bouaouina, Nadia Amrouni, Hammam Alshazly, Abdeldjalil Ouahabi
Summary: Automatic identity recognition from ear images is an active area of research, with potential applications in surveillance, authentication, and forensics. However, there are challenges that limit the commercial use of this technology. This paper reviews recent methods for describing and classifying biometric features of the ear, proposes a taxonomy for classifying existing approaches, and discusses the evolution of ear recognition datasets and the performance of conventional vs. deep learning methods. Future research challenges and trends are also debated.
Review
Otorhinolaryngology
Nithreen M. Said, Lena S. Telmesani, Laila M. Telmesani
Summary: The study aimed to assess the ECAP responses in children with inner ear malformations compared to children with normal inner ear anatomy. It was found that measurable ECAP responses can be elicited in most channels in patients with IEMs. However, severe malformations can affect the measurement of ECAP and the identification of waveform morphology. Additionally, patients with more severe malformations tend to have higher thresholds and lower slope of AGF. IPI patients with better word recognition scores tend to show more identifiable ECAP measurements, suggesting a possible correlation between ECAP responses and patients' performance after cochlear implantation.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)