Article
Oncology
Anja Paehler vor der Holte, Inger Fangk, Sabine Glombitza, Ludwig Wilkens, Hans J. Welkoborsky
Summary: Sinonasal papillomas have the potential for frequent recurrences and malignant progression, with HPV infection playing a role in these processes. Low-risk HPV infection increases the risk of tumor recurrences, while high-risk HPV infection promotes malignant progression.
Article
Medicine, Research & Experimental
Justin P. McCormick, Jeffrey D. Suh, Jivianne T. Lee, Christine Wells, Marilene B. Wang
Summary: This study suggests that infection with high-risk HPV subtypes may be associated with an increased risk of malignant SNIP, with HPV-18 showing the greatest overall average effect size of the common high-risk subtypes.
Article
Health Care Sciences & Services
Hitoshi Hirakawa, Taro Ikegami, Norimoto Kise, Hidetoshi Kinjyo, Shunsuke Kondo, Shinya Agena, Narumi Hasegawa, Junko Kawakami, Hiroyuki Maeda, Mikio Suzuki
Summary: This study investigated the roles of HPV infection and EGFR exon 20 mutations in sinonasal inverted papilloma (IP) and sinonasal squamous cell carcinoma (SNSCC). HPV DNA was found in a significant percentage of IP, IP-SCC, and SNSCC cases, along with p16 overexpression. EGFR exon 20 mutations were observed in IP and IP-SCC cases but not in SNSCC. The phosphorylation pattern of EGFR with exon 20 mutations resembled that of HPV-related SNSCC and oropharyngeal cancer. Further research is needed to understand the etiology of IP-SCC.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Virology
Kendal Rosalik, Christopher Tarney, Jasmine Han
Summary: HPV is the most common sexually transmitted infection worldwide, leading to various diseases, and vaccines are effective in preventing HPV-related diseases. There is a need for better global distribution and acceptance of vaccines to combat HPV.
Article
Oncology
Dongbin Ahn, Ji-Hye Kwak, Gil-Joon Lee, Jin-Ho Sohn
Summary: This study evaluated the prevalence and characteristics of human papillomavirus (HPV) infection in oropharyngeal squamous papilloma (OPSP), showing an overall prevalence of 14.5%. High-risk HPV types accounted for 75% of all HPV infections, with HPV16 being the most prevalent genotype, accounting for 58.3% of all HPV infections. Patients with OPSP aged <= 45 years, never-smokers, and those with multifocal diseases had a higher prevalence of high-risk HPV infection. These findings could enhance our understanding of HPV infection in OPSP and provide valuable epidemiological data for the management of HPV-associated OPSP.
Letter
Oncology
Smrithi Chidambaram, Su-Hsin Chang, Vlad C. Sandulache, Angela L. Mazul, Jose P. Zevallos
Summary: This cross-sectional study investigates the HPV vaccination rate and eligible population among younger veterans and civilians.
Article
Immunology
Tomasz Milecki, Maciej Michalak, Jakub Milecki, Michal Michalak, Radoslaw Kadziszewski, Lukasz Kuncman, Piotr Jarzemski, Piotr Milecki, Andrzej Antczak
Summary: The study aimed to evaluate medical students' knowledge of HPV transmission, cancer risk, and vaccination. Results showed gaps in understanding of HPV infection and transmission routes, with intention to recommend HPV vaccine by medical students being linked to their own knowledge and vaccination status.
Article
Medicine, Research & Experimental
Anusha Ponduri, Monica C. C. Azmy, Eden Axler, Juan Lin, Rachel Schwartz, Magdalena Chirila, Frederik G. G. Dikkers, Christina J. J. Yang, Vikas Mehta, Mona Gangar
Summary: The efficacy of HPV vaccination as an adjuvant therapy in recurrent respiratory papillomatosis (RRP) was characterized through a systematic review and meta-analysis of 13 studies. The addition of HPV vaccination was associated with increased intervals between surgeries and decreased number of surgical procedures required. This suggests that HPV vaccination may be a beneficial adjuvant treatment for RRP.
Letter
Medicine, General & Internal
Didem Egemen, Hormuzd A. Katki, Anil K. Chaturvedi, Rebecca Landy, Li C. Cheung
Summary: This survey study examined the self-reported status and timing of HPV vaccination among female participants in the National Health and Nutrition Examination Survey from 2011 to 2018.
Article
Virology
Taro Ikegami, Norimoto Kise, Hidetoshi Kinjyo, Shunsuke Kondo, Mikio Suzuki, Narutoshi Tsukahara, Akikazu Murakami, Asanori Kiyuna, Shinya Agena, Katsunori Tanaka, Narumi Hasegawa, Junko Kawakami, Akira Ganaha, Hiroyuki Maeda, Hitoshi Hirakawa
Summary: This study investigated the viral gene expression of HPV-11 and evaluated antibodies against HPV-6 and HPV-11 E4 protein in laryngeal papilloma (LP). The results showed potential clinical applications for these E4-specific antibodies in functional studies and targeted molecular therapies for patients with HPV-6 and HPV-11 infection.
Article
Immunology
Anyie J. Li, Fatuma Manzi, Furaha Kyesi, Yusuf Makame, William Mwengee, Monica Fleming, Abdallah Mkopi, Selemani Mmbaga, Dafrossa Lyimo, Anagha Loharikar
Summary: The HPV vaccination program in Tanzania was well accepted by community stakeholders in 18 councils, with adequate knowledge demonstrated by health workers and school personnel. However, continued technical support for integrating the vaccine into routine immunization activities and reinforcing basic knowledge about the vaccine in specific community groups is needed.
Article
Immunology
Shaheen Kurani, Kathy L. MacLaughlin, Robert M. Jacobson, Jennifer L. St Sauver, Gregory D. Jenkins, Chun Fan, Debra J. Jacobson, Jonathan Inselman, Xuan Zhu, Joan M. Griffin, Lila J. Finney Rutten
Summary: This study revealed that individuals living in areas of higher deprivation have lower likelihood of initiating and completing the HPV vaccine series.
Review
Otorhinolaryngology
Fabio Ferreli, Matteo Di Bari, Antoine Moya-Plana, Federica Canzano, Emanuela Morenghi, Armando De Virgilio, Giuseppe Mercante, Giuseppe Spriano, Giovanni Colombo
Summary: The study aimed to evaluate the association between human papillomavirus (HPV) infection and the transformation of sinonasal inverted papilloma. The results showed a significant increase in the risk of malignancy for sinonasal inverted papilloma in HPV-infected patients, especially those with high-risk HPV types. The presence of high-risk HPV also significantly increased the probability of malignant transformation in all geographical areas analyzed. These findings highlight the importance of HPV infection research during histological examination of sinonasal inverted papilloma.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Immunology
Loredana Sabina Cornelia Manolescu, Corina Zugravu, Corneliu Nicolae Zaharia, Anca Irina Dumitrescu, Irina Prasacu, Mihaela Corina Radu, Goraneanu Draghici Letitia, Irina Nita, Corina Marilena Cristache, Laurentia Nicoleta Gales
Summary: The aim of this study is to assess the barriers and facilitators of the current Romanian HPV vaccination campaign. The results showed that the inclusion of HPV vaccination in the National Vaccination Program is the most important factor in promoting vaccination. On the other hand, vaccine hesitancy often stems from the high cost of the vaccine and a lack of proper information.
Article
Immunology
Stephanie M. Wang, Emma A. Keegan, Katherine M. Bryan, Jamil Kazma, Kirsten J. H. Das, Beverly J. Long, Anna BuAbbud
Summary: This study investigated the attitudes of patients with a history of cervical dysplasia towards HPV vaccination and the counseling patterns of healthcare providers. The results showed that a small proportion of patients received the HPV vaccine, with a higher vaccination rate among White patients. The study also found that only a small number of patients received counseling regarding vaccination during their visits.
Article
Medicine, General & Internal
Yi-An Lu, Ming-Shao Tsai, Li-Ang Lee, Shu-Ru Lee, Li-Yun Lin, Chain-Fen Chang, Wan-Ni Lin, Li-Jen Hsin, Chun-Ta Liao, Hsueh-Yu Li, Yu-Wen Wen, Tuan-Jen Fang
Summary: Seeking medical assistance before a diagnosis of glottic cancer is related to better overall survival, while a diagnostic delay of more than 30 days from the first medical examination for dysphonia is associated with a worse outcome among patients with laryngeal cancer.
Article
Environmental Sciences
Meng-Chang Ding, Cheng-Ming Hsu, Stanley Yung-Chuan Liu, Yi-Chan Lee, Yao-Hsu Yang, Chia-Yen Liu, Geng-He Chang, Yao-Te Tsai, Li-Ang Lee, Pei-Rung Yang, Hsueh-Yu Li, Ming-Shao Tsai
Summary: The study confirms sleep apnea as an independent risk factor for deep neck infection. Sleep apnea increases the risk of DNI in men, those under the age of 50 without certain comorbidities. Physicians should be vigilant about the potential occurrence of DNI in patients with sleep apnea.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Oncology
Li-Ang Lee, Tuan-Jen Fang, Hsueh-Yu Li, Hai-Hua Chuang, Chung-Jan Kang, Kai-Ping Chang, Chun-Ta Liao, Tse-Ching Chen, Chung-Guei Huang, Tzu-Chen Yen
Summary: Epstein-Barr virus DNA positivity, age >= 55 years, cigarette smoking, and high expression of BCL-2, B2M, and CD161 were identified as independent risk factors for primary laryngeal squamous cell carcinoma. High EBER signal and low CD3 expression were significant predictors for local recurrence and disease-free survival within five years. This study provides valuable insights into the role of EBV infection in LSCC and can potentially guide precision medicine for patients.
Article
Oncology
Chung-Jan Kang, Yu-Wen Wen, Shu-Ru Lee, Li-Yu Lee, Chuen Hsueh, Chien-Yu Lin, Kang-Hsing Fan, Hung-Ming Wang, Chia-Hsun Hsieh, Shu-Hang Ng, Chih-Hua Yeh, Chih-Hung Lin, Chung-Kan Tsao, Tuan-Jen Fang, Shiang-Fu Huang, Li-Ang Lee, Ku-Hao Fang, Tzu-Chen Yen, Nai-Ming Cheng, Tsung-You Tsai, Shiao-Fwu Tai, Chi-Ying Tsai
Summary: This study addressed the controversy regarding the optimal cutoff values for surgical margins in oral cavity squamous cell carcinoma. The findings suggest that a margin status >4 mm can be considered as adequate.
Article
Biochemistry & Molecular Biology
Yi-Chieh Lee, Yu-Cheng Pei, Yi-An Lu, Hsiu-Feng Chung, Hsueh-Yu Li, Li-Ang Lee, Tuan-Jen Fang
Summary: The use of hyaluronic acid in early injection laryngoplasty for acute unilateral vocal fold paralysis is effective in improving voice and quality of life, with a lower rate of secondary procedures compared to permanent laryngoplasty. However, some patients may require secondary procedures, with higher re-treatment rates for those treated with low-concentrated hyaluronic acid.
Article
Cell Biology
Guo-Rung You, Joseph T. Chang, Hsiao-Fan Li, Ann-Joy Cheng
Summary: NDRG1 has diverse oncogenic functions in head and neck cancer cells, including stress response, cell motility, and upregulation of stemness-related markers. The 3R motif of NDRG1 plays a crucial role in cell motility, as phosphorylation at serine residues leads to nuclear translocation and promotes motility.
Article
Clinical Neurology
Ming-Shao Tsai, Hung-Chin Chen, Hsueh-Yu Li, Yao-Te Tsai, Yao-Hsu Yang, Chia-Yen Liu, Yi-Chan Lee, Cheng-Ming Hsu, Li-Ang Lee
Summary: Sleep apnea increases the risk of severe acute respiratory infection (SARI) following influenza. Sleep apnea, chronic obstructive pulmonary disease, and coronary artery disease are independent risk factors for influenza-associated SARI.
NATURE AND SCIENCE OF SLEEP
(2022)
Review
Biochemistry & Molecular Biology
Hsin-Ying Chen, Ann-Joy Cheng
Summary: Cancer stemness, characterized by unlimited self-renewal, low percentage, asymmetric/symmetric cell division, and different nature for absorbing external substances, is proposed to be the main cause of metastasis and tumor relapse. Glucose-regulated protein 78 (GRP78) plays a key role in cancer stemness and could serve as a feasible target for eradicating cancer stem cells.
Article
Clinical Neurology
Hai-Hua Chuang, Chao-Yung Wang, Li-Pang Chuang, Yu-Shu Huang, Hsueh-Yu Li, Tuan-Jen Fang, Rong-Ho Lin, Li-Ang Lee
Summary: This study investigated the associations between oxygen desaturation index, body mass index, sleep hypoxemia, and hypertension in pediatric obstructive sleep apnea (OSA) patients. The results showed that oxygen desaturation index and body mass index were independent predictors of pediatric hypertension. The study also found that the severity of sleep hypoxemia had different effects on predicting hypertension in OSA patients. This highlights the importance of reducing sleep hypoxemia and body weight in children with OSA.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Medicine, General & Internal
Yu-Cheng Wu, Tuan-Jen Fang, Hsiu-Feng Chuang, Alice M. K. Wong, Yu-Cheng Pei
Summary: This study compares the impact of cricothyroid muscle dysfunction on language tone in patients with unilateral vocal fold paralysis (UVFP). It finds that cricothyroid dysfunction limits high-rising tone in Mandarin Tone 2 and high-falling tone in Mandarin Tone 4, affecting communication ability.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Li-Jen Hsin, Yi-Chan Lee, Wan-Ni Lin, Yi-An Lu, Li-Ang Lee, Ming-Shao Tsai, Wen-Nuan Cheng, Yen-Ting Chiang, Hsueh-Yu Li
Summary: This study evaluated the safety and efficacy of a novel technique called transoral tongue suspension (TOTS) for treating obstructive sleep apnea patients. The results showed significant improvement in patients' quality of life and objective parameters, with low surgical risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Guo-Rung You, Joseph T. Chang, Yan-Liang Li, Chi-Wei Huang, Yu-Liang Tsai, Kang-Hsing Fan, Chung-Jan Kang, Shiang-Fu Huang, Po-Hung Chang, Ann-Joy Cheng
Summary: The study discovered that MYH9 is overexpressed in head and neck cancer, and is associated with poor prognosis. MYH9 promotes cell motility and modulates the extracellular matrix, and is also related to radioresistance and the expression of anti-apoptotic molecules. Mechanically, MYH9 suppresses cellular ROS levels by activating the MAPK-Nrf2-GCLC signaling pathway.
Article
Medicine, General & Internal
Chun-Ting Lu, Li-Ang Lee, Guo-She Lee, Hsueh-Yu Li
Summary: The study aimed to investigate the relationship between obstructive sleep apnea and auditory dysfunction, particularly the role of snoring sounds. The results showed that OSA patients with tinnitus had higher ESS scores and intra-ear canal SSE compared to those without tinnitus. OSA patients with daytime sleepiness were at a higher risk of tinnitus.
Article
Biochemistry & Molecular Biology
Shang-Ju Tang, Kang-Hsing Fan, Guo-Rung You, Shiang-Fu Huang, Chung-Jan Kang, Yi-Fang Huang, Yu-Chen Huang, Joseph Tung-Chieh Chang, Ann-Joy Cheng
Summary: The study identified a specific profile of miRNAs in head and neck cancer cells, further revealing the role of miR-503 as a tumor suppressor gene, inhibiting cell invasion through the Wnt signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Chia-Chen Lin, Keng-Hao Liu, Li-Ang Lee, Li-Pang Chuang, Yu-Sheng Lin, Li-Jen Hsin, Wan-Ni Lin, Yen-Ting Chiang, Wen-Nuan Cheng, Hsueh-Yu Li
Summary: This study proposes a comprehensive technique called combined airway and bariatric surgery (CABS) to improve both obesity and obstructive sleep apnea (OSA). The retrospective study showed that CABS can significantly improve AHI and BMI in morbidly obese OSA patients, with high success and cure rates for OSA, as well as improved quality of life and general health.
JOURNAL OF CLINICAL MEDICINE
(2022)