Article
Chemistry, Multidisciplinary
Maria Sanz-Paz, Fangjia Zhu, Nicolas Bruder, Karol Kolataj, Antonio I. Fernandez-Dominguez, Guillermo P. Acuna
Summary: By modifying the local density of photonic states, optical nanoantennas can alter the emission spectrum of a dye. In this study, DNA origami was used to precisely position an individual dye around a gold nanorod and observe how it affects the emission spectrum. The spectral overlap between the nanorod resonance and different vibrational levels of the dye's excitonic ground state can lead to strong suppression or enhancement of transitions.
Article
Chemistry, Multidisciplinary
Kateryna Trofymchuk, Karol Kolataj, Viktorija Glembockyte, Fangjia Zhu, Guillermo P. Acuna, Tim Liedl, Philip Tinnefeld
Summary: DNA origami has become a leading technology for organizing materials at the nanoscale, particularly for manipulating light using plasmonic nanoparticles. In this study, gold nanorods were arranged in a plasmonic nanoantenna dimer, resulting in a 1600-fold enhancement of fluorescence from a conventional near-infrared dye located at the plasmonic hotspot between the nanorods. Various characterization techniques and numerical simulations provided insights into the heterogeneity of the observed enhancement values. The use of a recently introduced design called NAnoantenna with Cleared HotSpot (NACHOS) enabled the creation of a hotspot region with a size of approximately 12 nm, which allows for the incorporation of tailored bioassays. The possibility of synthesizing nanoantennas in solution opens the potential for large-scale production.
Article
Chemistry, Multidisciplinary
Fangjia Zhu, Maria Sanz-Paz, Antonio Fernandez-Dominguez, Xiaolu Zhuo, Luis M. Liz-Marzan, Fernando D. Stefani, Mauricio Pilo-Pais, Guillermo P. Acuna
Summary: Optical antennas are nanostructures designed to manipulate light-matter interactions by interfacing propagating light with localized optical fields. Successful phased array nanoantenna designs have required the organization of several elements over a footprint comparable to the operating wavelength. This study reports unidirectional emission of a single fluorophore using an ultracompact optical antenna, achieving high forward to backward ratio.
Article
Chemistry, Multidisciplinary
Aleksandra K. Adamczyk, Teun A. P. M. Huijben, Miguel Sison, Andrea Di Luca, Stefano Vanni, Sophie Brasselet, Kim I. Mortensen, Fernando D. Stefani, Mauricio Pilo-Pais, Guillermo P. Acuna
Summary: This study demonstrates a controlled orientation of single molecules in DNA origami by linking them to oligonucleotide strands and leaving unpaired bases. The number of unpaired bases affects the stretching and orientation of the fluorophore linkers. These findings expand the application of DNA origami in the fabrication of nanodevices involving orientation-dependent molecular interactions.
Review
Chemistry, Multidisciplinary
Sihai Luo, Bard H. Hoff, Stefan A. Maier, John C. de Mello
Summary: This study evaluates some of the most promising techniques for nanogap fabrication, including traditional methods like photolithography, electron-beam lithography, and focused ion beam milling, as well as newer methods using novel electrochemical and mechanical means for patterning. The physical principles behind each method are reviewed, and their strengths and limitations for nanogap patterning are discussed in terms of resolution, fidelity, speed, ease of implementation, versatility, and scalability to large substrate sizes.
Article
Chemistry, Multidisciplinary
Peng Mao, Changxu Liu, Yubiao Niu, Yuyuan Qin, Fengqi Song, Min Han, Richard E. Palmer, Stefan A. Maier, Shuang Zhang
Summary: Materials exhibit diverse responses to incident light based on their unique dielectric functions, with the optical response in nanotechnology being influenced by both material properties and geometric structures. The advancement of nanotechnology has led to significant progress in optical structures with feature sizes smaller than the optical wavelength, resulting in flourishing developments in plasmonics and photonic crystals. A counterintuitive system consisting of plasmonic nanostructures composed of different materials but exhibiting almost identical reflection has been proposed, highlighting the insensitivity of the optical response to different plasmonic materials.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
David Winogradoff, Pin-Yi Li, Himanshu Joshi, Lauren Quednau, Christopher Maffeo, Aleksei Aksimentiev
Summary: The chemical structure of DNA has implications for self-organization and building functional nanostructures, with recent advances focusing on natural and synthetic chiral systems using DNA. The role of nucleic acid chirality in various situations, liquid crystal phases, and efforts to build chiral structures through DNA self-assembly are discussed. Current and proposed man-made nanostructures designed to probe or utilize DNA's chirality are also explored, from plasmonics to biosensing.
Article
Chemistry, Multidisciplinary
Michael Erkelenz, Richard Kosinski, Oliver Sritharan, Helene Giesler, Barbara Sacca, Sebastian Schlucker
Summary: In this study, bare gold nanocubes and nanospheres of different sizes were incorporated into a rationally designed 3D DNA origami box. The encapsulated particles exhibit a gold surface that can be functionalized for specific applications in molecular plasmonics such as SERS or SEF.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Liam Collard, Filippo Pisano, Di Zheng, Antonio Balena, Muhammad Fayyaz Kashif, Marco Pisanello, Antonella D'Orazio, Liset M. de la Prida, Cristian Ciraci, Marco Grande, Massimo De Vittorio, Ferruccio Pisanello
Summary: This paper discusses the integration of plasmonic structures on optical fibers and its potential applications. The turbidity of light propagation in multimode fibers hinders dynamic control of the coupling between guided light fields and plasmonic resonances. Utilizing the information of guided modes, the authors demonstrate the spatiotemporal control of plasmonic resonances by employing dynamic phase modulation.
Article
Chemistry, Physical
Jiahao Pan, Xiaoyao Wang, Jinjin Zhang, Qin Zhang, Qiangbin Wang, Chao Zhou
Summary: By assembling helical plasmonic nanorods with intrinsic chirality, we have created plasmonic metamolecules with both chiral coupling and intrinsic chiroptical responses. These metamolecules offer more dimensions for tailoring chiroptical responses and make it more flexible to design plasmonic nanodevices with custom PCD.
Article
Chemistry, Multidisciplinary
Joonas Ryssy, Ashwin K. Natarajan, Jinhua Wang, Arttu J. Lehtonen, Minh-Kha Nguyen, Rafal Klajn, Anton Kuzyk
Summary: The article describes a method for remotely manipulating non-photoresponsive chiral plasmonic molecules (CPMs) using light, inducing DNA triplex link formation through a photoacid medium, resulting in spatial reconfiguration of CPMs. The overall chirality change depends on the fraction of CPMs undergoing reconfiguration, which is related to the intensity of incident light.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Nanoscience & Nanotechnology
Dong Zhao, Zhelin Lin, Wenqi Zhu, Henri J. Lezec, Ting Xu, Amit Agrawal, Cheng Zhang, Kun Huang
Summary: Nanophotonic devices, made of metals, dielectrics, or semiconductors, offer precise manipulation of electromagnetic waves at subwavelength scales. They are revolutionizing optical devices across the infrared, visible, and ultraviolet spectra with their compact size, versatile functionality, and exceptional performance. In the ultraviolet spectral region, advances in nanophotonic elements like plasmonic devices, optical metamaterials, and optical metasurfaces are providing new opportunities for imaging, sensing, and spectroscopy applications, while also presenting challenges for future development.
Article
Multidisciplinary Sciences
Muren Hu, Chang Feng, Qianqin Yuan, Chenbin Liu, Bujun Ge, Fenyong Sun, Xiaoli Zhu
Summary: mRNA delivery has shown great potential in the treatment of various diseases. Here, the authors develop a lantern-shaped flexible origami for the nanolization of single mRNA molecules and demonstrate efficient delivery of Smad4 mRNA, achieving the suppression of colorectal cancer tumor growth.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Lisa Saemisch, Niek F. van Hulst, Matz Liebel
Summary: Controlling phase at the nanoscale is a powerful method for tailoring electrical fields in nanophotonics. However, measuring the phase response of individual nanostructures experimentally is extremely challenging. A new method is proposed to distinguish different types of nanoparticles based on their phase behavior, and it is integrated into a single-shot two-color scheme for directly identifying different nanoparticles on a single sample.
Article
Chemistry, Multidisciplinary
Eitan Oksenberg, Ilan Shlesinger, Gokcen Tek, A. Femius Koenderink, Erik C. C. Garnett
Summary: The surface-enhanced counterparts of Raman scattering (SERS) and infrared (IR) absorption (SEIRAS) are commonly used to probe and identify nanoscale matter and small populations of molecules. In this study, a complementary surface-enhanced vibrational spectroscopy approach is presented to probe the vibrational signature of metal-bound molecular monolayers. Nanocavities are designed and produced with sharp and tunable visible (VIS) and mid-IR gap resonances by placing nanorods on a mirror that is coated with a thin dielectric spacer.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemical Research Methods
Sofia Julin, Adrian Keller, Veikko Linko
Summary: Hierarchical assembly of programmable DNA frameworks, such as DNA origami, has paved the way for versatile nanometer-precise parallel nanopatterning up to macroscopic scales. However, the dynamics of large-scale lattice assembly of such modules is still poorly understood. This article focuses on the dynamics of two-dimensional surface-assisted DNA origami lattice assembly and prospective three-dimensional assemblies, and summarizes their potential applications.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Materials Science, Paper & Wood
Isaac Y. Miranda-Valdez, Sebastian Coffeng, Yu Zhou, Leevi Viitanen, Xiang Hu, Luisa Jannuzzi, Antti Puisto, Mauri A. Kostiainen, Tero Makinen, Juha Koivisto, Mikko J. Alava
Summary: Foam-formed cellulose biocomposites with added organosolv lignin enhance the properties required for applications such as insulation, packaging, and cushioning. The addition of lignin increases Young's modulus, protects against bacterial growth, and improves surface hydrophobicity. The optimization of the foam composition offers a potential path for industrial-scale development.
Article
Chemistry, Multidisciplinary
Ioanna Smyrlaki, Alan Shaw, Yunshi Yang, Boxuan Shen, Bjoern Hoegberg
Summary: The introduction of the solid phase method for synthesizing biopolymers has revolutionized the field of biological research. The DNA origami method, which constructs well-defined structures at the nanoscale using nucleotide base-pairing, has become a powerful tool for manipulating matter in various fields. This article reports a method for synthesizing DNA nanostructures directly on magnetic beads, allowing for efficient folding and purification.
Article
Virology
Swarnalok De, Hoang M. Nguyen, Ville Liljestrom, Kristiina Makinen, Mauri A. Kostiainen, Jaana Vapaavuori
Summary: This study investigates the liquid crystal and interfacial self-assembly behavior of potato virus A (PVA) and demonstrates the generation of nanopatterned surfaces using self-assembled PVA particles through three different coating techniques. The study reveals the ability of PVA to self-assemble into different structures under different conditions, providing a virus-assisted fabrication technique for nanopatterned surfaces.
Article
Chemistry, Multidisciplinary
Marco Lolaico, Sebbe Blokhuizen, Boxuan Shen, Yang Wang, Bjorn Hogberg
Summary: In recent years, there has been a growing interest in wireframe DNA origami, with various designs, software, and applications emerging rapidly. This study focuses on increasing the design options for A-trail routed wireframe DNA structures by incorporating four-helix bundles (4HB). The researchers developed software for designing these structures, successfully demonstrated the design and folding of a library of structures, and investigated the mechanical rigidity of the reinforced structures. The scaffold routing technique allows for the easy incorporation of reinforced edges and flexible single helix edges, enabling customization of the desired structure's stiffness. The successful folding of hybrid structures and the characterization of different stiffness levels using computational and experimental approaches were demonstrated.
Article
Multidisciplinary Sciences
Christopher Jonkergouw, Ngong Kodiah Beyeh, Ekaterina Osmekhina, Katarzyna Leskinen, S. Maryamdokht Taimoory, Dmitrii Fedorov, Eduardo Anaya-Plaza, Mauri A. Kostiainen, John F. Trant, Robin H. A. Ras, Paivi Saavalainen, Markus B. Linder
Summary: A water-soluble synthetic macrocycle, Pillar[5]arene, has been identified to bind to key virulence factors in Gram-negative pathogens, suppressing toxins and biofilms and enhancing the efficacy of standard antibiotics. It evades existing antibiotic resistance mechanisms and shows promise as a dual-acting anti-virulence treatment against Top Priority pathogens.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Mattia Nieddu, Marta Patrian, Sara Ferrara, Juan Pablo Fuenzalida Werner, Fabian Kohler, Eduardo Anaya-Plaza, Mauri A. Kostiainen, Hendrik Dietz, Jesus Ruben Berenguer, Ruben D. Costa
Summary: This work presents a new concept of using FP@SiO2 nanoparticles to address the issues of thermal emission quenching and H-transfer deactivation in biohybrid light-emitting diodes (Bio-HLEDs). By shielding the FP core with a SiO2-shell, stable and efficient high-power Bio-HLEDs were achieved, with a brightness of 100 lm W-1 for over 120 hours.
Article
Nanoscience & Nanotechnology
Iris Seitz, Sharon Saarinen, Esa-Pekka Kumpula, Donna McNeale, Eduardo Anaya-Plaza, Vili Lampinen, Vesa P. Hytoenen, Frank Sainsbury, Jeroen J. L. M. Cornelissen, Veikko Linko, Juha T. Huiskonen, Mauri A. Kostiainen
Summary: DNA and RNA origami nanostructures can be used to control the size, shape, and topology of virus capsids, while also protecting encapsulated origami structures from degradation.
NATURE NANOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jingwen Xia, Tetyana Koso, Katja Heise, Lukas Fliri, Emilie Ressouche, Johanna Majoinen, Mauri A. Kostiainen, Sami Hietala, Michael Hummel, Vladimir Aseyev, Ilkka Kilpelainen, Alistair W. T. King
Summary: The reaction between reducing end groups in cellulose nanocrystals and dodecylamine was investigated, demonstrating the regioselective formation of glucosylamines using direct-dissolution solution-state NMR protocol. This offers an elegant approach to sustainably functionalize these bio-based nanomaterials, potentially eliminating the need for further reduction to more stable secondary amines.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Kabusure M. Kabusure, Petteri Piskunen, Jiaqi Yang, Veikko Linko, Tommi K. Hakala
Summary: We present efficient SERS supporting substrates based on DNA-assisted lithography and a layered configuration of materials. The hybrid nanostructures consisting of aligned silver bowtie-shaped particles and apertures in a silver film demonstrated a four-fold improvement in Raman enhancement compared to conventional particle-based substrates. Our findings were confirmed by experiments and simulations. The optically resonant substrates fabricated using the versatile and parallel DNA origami-based nanofabrication scheme are attractive for various SERS-based applications.
Article
Chemistry, Multidisciplinary
Swarnalok De, Hoang M. Nguyen, Fangxin Zou, Fevzihan Basarir, Maryam Mousavi, Kristiina Maekinen, Mauri A. Kostiainen, Jaana Vapaavuori
Summary: In this study, a glass substrate patterned with dense arrays of silver nanoparticles templated on an interconnected network of flexible virus nanoparticles is developed. The templated substrate demonstrates outstanding photothermal performance without compromising excellent light transmittance. Additionally, it displays highly efficient defogging capabilities in various environmental conditions, including both indoor and outdoor settings.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Sofia Julin, Nadine Best, Eduardo Anaya-Plaza, Eeva Enlund, Veikko Linko, Mauri A. Kostiainen
Summary: Stimuli-responsive lipid-DNA origami fibers were formed through electrostatic co-assembly of cationic lipids and 6-helix bundle (6HB) DNA origami. The photosensitive lipid degrades under UV-A light and allows controlled release of 6HBs from the fibers.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Marco Lolaico, Sebbe Blokhuizen, Boxuan Shen, Yang Wang, Bjorn Hogberg
Summary: Interest in wireframe DNA origami has been growing, with different designs and software emerging rapidly. In this study, we enhance the design options for A-trail routed wireframe DNA structures by introducing four-helix bundles. We develop software for designing these structures, successfully create and fold a library of structures, and investigate the mechanical rigidity of the reinforced ones. The scaffold routing allows for easy incorporation of reinforced edges and flexible single helix edges, enabling customization of structure stiffness.
Article
Materials Science, Biomaterials
Eduardo Anaya-Plaza, Zulal Ozdemir, Zdenek Wimmer, Mauri A. Kostiainen
Summary: In this research, the morpheein behavior of Prx is utilized to achieve the self-assembly of columnar aggregates, which further form 3D anisotropic bundles. This precise assembly is achieved by the interaction between negatively charged protein rim and positively charged porphyrin acting as molecular glue.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
