Article
Chemistry, Physical
Eleanor L. Brightbill, Hilena F. Gezahagne, Decarle S. Jin, Billyde Brown, Eric M. Vogel
Summary: Blocking COOH-SAMs with gelatin can prevent oxidation and degradation, extending the sensor's shelf life and maintaining surface-plasmon-resonance-based sensing performance for at least one week.
APPLIED SURFACE SCIENCE
(2021)
Article
Engineering, Chemical
Zheng Chen, Mingrui Liao, Lizhi Zhang, Jian Zhou
Summary: Zwitterionic materials show strong hydration and underwater oleophobicity, with optimal performance when the carbon spacer length is 3. The addition of NaCl can enhance the properties by weakening self-association of molecules.
Review
Chemistry, Multidisciplinary
Limin Wang, Ulrich S. Schubert, Stephanie Hoeppener
Summary: Surface modification using self-assembled monolayers has seen significant advancement in the past decade, with the introduction of new chemical reactions such as nucleophilic substitution, click chemistry, supramolecular modification, photochemical reaction, and others, enhancing the properties of solid substrates like silicon and glass.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Multidisciplinary Sciences
Samuel J. Lounder, Ayse Asatekin
Summary: Research shows that water filtration membranes with cross-linked zwitterionic copolymer membranes exhibit high ion selectivity, controlling salt partitioning and diffusivity for efficient salt separation. These membranes also achieve high fluoride retention and high chloride passage in saline mixtures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Yiming Zhang, Yinghao Ding, Xinxin Li, Debin Zheng, Jie Gao, Zhimou Yang
Summary: Zwitterionic polymer materials have been extensively studied, but zwitterionic peptides supramolecular hydrogel materials are rarely studied. In this study, the preparation of two zwitterionic hydrogels using self-assembled peptides were reported. The differences in structure and function of the zwitterion peptide hydrogels caused by the two preparation methods were compared, with the enzyme induced self-assembly method showing better solubility and lower cytotoxicity.
CHINESE CHEMICAL LETTERS
(2021)
Review
Chemistry, Analytical
Seongjae Kim, Hocheon Yoo
Summary: SAMs, as self-assembled monolayers, have various functions in electronic devices, serving as ultrathin gate dielectric layers and semiconducting active layers, and are also applied in other electronic applications.
Article
Chemistry, Physical
Angelo Tricase, Davide Blasi, Alessandro Favia, Angela Stefanachi, Francesco Leonetti, Giuseppe Colafemmina, Luisa Torsi, Gaetano Scamarcio
Summary: The study investigated the synthesis of self-assembled monolayers of NMPA on Au films using infrared spectroscopy and found that the reaction yield was significantly influenced by the acidity of the EDC/NHSS solutions.
APPLIED SURFACE SCIENCE
(2021)
Review
Polymer Science
Shoukui Hu, Jinhao Yan, Guangwei Yang, Chao Ma, Jun Yin
Summary: This Review summarizes the current research advances in the synthesis of various amphiphilic block copolymers (ABCs), the design of self-assembled structures driven by intermolecular interactions, and the applications in different fields. It also discusses the challenges and future prospects in this area.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Ryongsok Chang, Evan Angelo Quimada Mondarte, Debabrata Palai, Taito Sekine, Aki Kashiwazaki, Daiki Murakami, Masaru Tanaka, Tomohiro Hayashi
Summary: Peptide-SAMs with specific zwitterionic sequences exhibit anti-biofouling properties, with EK and DK SAMs showing excellent resistance to protein and cell adhesion while ER and DR SAMs adhere proteins and cells. Surface force measurements using AFM reveal that a water-induced repulsion occurs between EK and DK SAMs within a range of about 8 nm, suggesting that interfacial water acts as a physical barrier preventing protein and cell adsorption.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Gyu Don Kong, Hyunsun Song, Seungmin Yoon, Hungu Kang, Rakwoo Chang, Hyo Jae Yoon
Summary: Interstitially mixed self-assembled monolayers (imSAMs) remarkably enhance the electrical stability of molecular-scale electronic devices without deteriorating function and reliability. This is achieved through the new approach of repeated surface exchange of molecules (ReSEM), filling the interstices between matrix molecules with reinforcement molecules to significantly enhance breakdown voltage.
Article
Chemistry, Multidisciplinary
Shakil N. N. Afraj, Chun-Hsiao Kuan, Jian-Sing Lin, Jen-Shyang Ni, Arulmozhi Velusamy, Ming-Chou Chen, Eric Wei-Guang Diau
Summary: Four X-shaped quinoxaline-based organic dyes, PQx (1), TQx, (2), PQxD (3), and TQxD (4), are developed as p-type self-assemble monolayer (SAM) for tin perovskite solar cells (TPSC). The thermal, optical, and electrochemical properties of these SAMs are thoroughly investigated. Tin perovskite layers are successfully deposited on these SAM surfaces using a two-step approach, and the achieved device performance follows the order of TQxD (8.3%) > TQx (8.0%) > PQxD (7.1%) > PQx (6.1%). Among them, TQxD (4), with a thiophene pi-extended conjugation unit in the SAM structure, exhibits the highest hole extraction rates, greatest hole mobilities, and slowest charge recombination, leading to the best reported efficiency of 8.3% for SAM-based TPSC. Moreover, all devices except PQx show good enduring stability, retaining approximately 90% of their original values after 1600 hours of shelf storage.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemical Research Methods
Maurice Retout, Pascale Blond, Ivan Jabin, Gilles Bruylants
Summary: A novel functionalization strategy based on calix[4]arene-tetradiazonium platforms for coating gold nanoparticles (AuNPs) with a robust PEG layer and controlled bioconjugation was reported. The resulting particles showed excellent chemical and colloidal stabilities, and can be dispersed in human serum without degrading or aggregating. The control of bioconjugation was achieved by grafting mixed layers of functional and nonfunctional PEGylated calix[4]arenes, allowing varying the number of functional groups on the AuNPs and their bioconjugation capacity while maintaining a dense protective PEG shell.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Julien Gay, Agata Lachowicz, Nicolas Blondiaux, Gaelle A. L. Andreatta
Summary: This study presents a method for nickel and copper electroplating on solar cells using phosphonic acid self-assembled monolayers as masks. The chemical functionalization and deposition method of phosphonic acid were found to strongly influence the masking properties, and the binding modes of phosphonic acid were investigated using attenuated total reflectance Fourier transform infrared spectroscopy.
ACS APPLIED NANO MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Anders Henriksson, Peter Neubauer, Mario Birkholz
Summary: In recent decades, alternative protocols have been developed to form bifunctional Si-C interlayers that directly bind to the silicon surface, providing more stability and reducing electric noise in biosensor devices. Despite their complexity and the need for an inert gas atmosphere, these innovative methods are predicted to expand the applications of future silicon-based biosensors.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Polymer Science
Zhao-yang Zhang, Tao Li
Summary: Molecular-scale electronics is an emerging research field that aims to achieve electronic functions using single molecules and their monolayer assemblies. Advances in fabricating SAM devices and optimizing their performance can lead to practical applications in molecular electronics. Conjugated polymers show distinct advantages in SAM devices, outperforming small molecular materials in optoelectronic functions such as on-off ratios for switches.
ACTA POLYMERICA SINICA
(2021)
Article
Biochemical Research Methods
Wen-Yu Chen, Chih-Hsien Wang, Kai-Hao Wang, Yuh-Ling Chen, Lai-Kwan Chau, Shau-Chun Wang
Article
Chemistry, Multidisciplinary
Tien-Jung Lee, Lai-Kwan Chau, Chun-Jen Huang
Article
Chemistry, Analytical
Yen-Ta Tseng, Wan-Yun Li, Ya-Wen Yu, Chang-Yue Chiang, Su-Qin Liu, Lai-Kwan Chau, Ning-Sheng Lai, Cheng-Chung Chou
Article
Biochemical Research Methods
Loan Thi Ngo, Wei-Kai Wang, Yen-Ta Tseng, Ting-Chou Chang, Pao-Lin Kuo, Lai-Kwan Chau, Tze-Ta Huang
Summary: A new biosensing method utilizing MutS protein and fiber optic particle plasmon resonance (FOPPR) sensing system has been developed to detect gene mutations with high sensitivity (limit of detection down to 0.49 nM) and short analysis time (as short as 15 min). Validation using patient samples has shown accurate determination of allelic fraction, making this method a promising tool for detecting single nucleotide polymorphisms in biological samples at point-of-care sites.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Chien-Hsing Chen, Chang-Yue Chiang, Chin-Wei Wu, Chien-Tsung Wang, Lai-Kwan Chau
Summary: A novel fiber optic particle plasmon resonance biosensing platform for immunoglobulin G (IgG) detection was developed using a gold nanoparticle/graphene oxide composite as a signal amplification element. The sensor showed good analytical performance with a detection limit of 0.038 ng/mL and a linear relationship between sensor response and analyte concentrations. The sensitivity was attributed to the synergistic effect between graphene oxide and gold nanoparticles, with good reproducibility demonstrated for IgG detection.
Correction
Biochemical Research Methods
Loan Thi Ngo, Wei-Kai Wang, Yen-Ta Tseng, Ting-Chou Chang, Pao-Lin Kuo, Lai-Kwan Chau, Tze-Ta Huang
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Shuo-Feng Wang, Wen-Yu Lin, Jia-Shan Dai, Yen-Ling Chen, Yung-fou Chen, Lai-Kwan Chau
Summary: A gold nanoparticle-based SALDI-MS method was developed for the analysis of amphetamine-type stimulants (ATS) through derivatization, which significantly increased ion signal intensities. The method was successfully applied to urine samples for the determination of MA and MDMA, demonstrating improved sensitivity and validation.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2021)
Article
Nanoscience & Nanotechnology
Shu-Mei Fan, Chang-Yue Chiang, Yen-Ta Tseng, Tsung-Yan Wu, Yen-Ling Chen, Chun-Jen Huang, Lai-Kwan Chau
Summary: The introduced fast and ultrasensitive biosensing method for detecting highly toxic mercury ions relies on fiber optic particle plasmon resonance and a selective molecular beacon. It offers a wide linear range and an extremely low detection limit. The method is suitable for point-of-use applications due to its low-cost instrumentation, ease of use, and portability.
ACS APPLIED NANO MATERIALS
(2021)
Article
Engineering, Chemical
Shi-Wen Chen, Tran Thi Anh Hong, Chun-Tung Chiang, Lai-Kwan Chau, Chun-Jen Huang
Summary: Organosilanes have been widely used in sol-gel material synthesis, surface functionalization, and nanotechnology. However, the limitations of organosilane have led to the emerging interest in silatrane, which offers unique tricyclic caged structure and chemical stability. This study demonstrated the application of silatrane in modifying silicon oxide substrates, achieving thin and uniform coatings. The functionalization of silatrane with polymers and immobilization of gold nanoparticles were also successfully achieved. The results showed superior protein repellency of MPS-PEGMA films compared to MPTMS-PEGMA films, and the cluster size of gold nanoparticles on APS films increased significantly after acid treatment.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Article
Chemistry, Multidisciplinary
Cheng-Chung Chang, Chia-Feng Hsieh, Hsing-Ju Wu, Mohamed Ameen, Tun-Pin Hung
Summary: Sonodynamic therapy (SDT) offers a noninvasive approach for tumor treatment by using ultrasound to activate a sonosensitizer. Two synthesized phenothiazine derivatives showed potential as photosensitizers and sonosensitizers. Among them, compound MB6C exhibited superior therapeutic effects and could be a potential candidate for photodynamic therapy (PDT) and SDT.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Han-Long Liu, Yen-Ta Tseng, Mei-Chu Lai, Lai-Kwan Chau
Summary: In this study, a fiber optic nanogold-linked immunosorbent assay (FONLISA) method was developed for the rapid, sensitive, and low-cost detection of the important blood biomarker for heart failure, N-terminal pro-brain natriuretic peptide (NT-proBNP). The method utilizes a sandwich immunoassay approach and detects the analyte through changes in light intensity caused by AuNPs on the fiber core surface. The method exhibits a wide dynamic range and a low limit of detection, and shows good correlation with a commercial laboratory-based method. This method has the potential to be used as a point-of-care testing tool.
Article
Chemistry, Analytical
Ting-Chou Chang, Aileen Y. Sun, Yu-Chung Huang, Chih-Hui Wang, Shau-Chun Wang, Lai-Kwan Chau
Summary: The global pandemic of COVID-19 has driven the demand for sensitive and rapid point-of-care testing methods. This study introduces a fiber optic particle plasmon resonance biosensor that utilizes a single-stranded DNA aptamer to detect the SARS-CoV-2 nucleocapsid protein with a 15-minute detection time and a limit of detection of 2.8 nM.
Article
Chemistry, Analytical
Yuan-Yu Chen, Chih-Lu Wu, Chia-Wei Hsu, Chih-Hui Wang, Chung-Rui Su, Chun-Jen Huang, Hau-Ren Chen, Lai-Kwan Chau, Shau-Chun Wang
Summary: A fast and label-free fiber optic particle plasmon resonance (FOPPR) immunosensing method was developed to detect nervous necrosis virus (NNV) in high-value economic aquatic species. With an enhancement method, it showed high sensitivity and potential as an outbreak surveillance tool.
Article
Chemistry, Analytical
Yi-Chen Chen, Yu-Chen Chou, Jui-Han Chang, Li-Ting Chen, Chun-Jen Huang, Lai-Kwan Chau, Yen-Ling Chen
Summary: A dual-functional gold-iron oxide core-satellite hybrid nanoparticle structure is proposed as a signal reporter and preconcentrator for low abundance analytes in a nanoplasmonic biosensor, demonstrating an 18-fold improvement in limit of detection for detecting DNA compared to traditional methods. This easy-to-prepare structure shows promise for high-sensitivity and low-cost point-of-care applications.
Article
Materials Science, Multidisciplinary
Duc Tu Vu, Thanh Thu Vu-Le, Van Nghia Nguyen, Quoc Minh Le, Churng-Ren Chris Wang, Lai-Kwan Chau, Tzyy-Schiuan Yang, Michael W. Y. Chang, Cheng- Lee, Chu-Chi Ting, Jiunn-Yuan Lin, Hung-Chih Kan, Chia Chen Hsu
Summary: In this study, a multifunctional nanocomposite was developed for effective treatment of oral cancer cells, demonstrating fluorescence labeling, temperature sensing, and photothermal functions. The temperature-dependent upconversion luminescence property was utilized to determine local temperature, and the nanocomposite particles successfully labeled cancer cells on the surface.
INTERNATIONAL JOURNAL OF SMART AND NANO MATERIALS
(2021)