Review
Materials Science, Multidisciplinary
Kazuhiko Ishihara
Summary: This review summarizes recent research on the design of polymer material systems based on biomimetic concepts and reports on medical devices implementing these systems. Incorporating biomolecules into artificial systems can significantly advance material science. Zwitterionic polymers have unique properties that make them potential surface modification materials for enhancing the performance and safety of conventional medical devices. New surface technologies using zwitterionic polymers have been developed for human-friendly medical devices in various fields.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2022)
Article
Polymer Science
Zhiqian Wang, Sumona Paul, Louis H. Stein, Arash Salemi, Somenath Mitra
Summary: Superhydrophobic surfaces have promising applications in the medical field, especially in blood-contacting devices. These surfaces can control cell-surface interactions, facilitate blood or plasma flow, and resist biofouling. Researchers have developed methods to fabricate blood-compatible or biocompatible superhydrophobic surfaces using different materials, making them ideal for clinical applications.
Article
Chemistry, Multidisciplinary
Martina Cihova, Eike Muller, Yashoda Chandorkar, Kerstin Thorwarth, Giuseppino Fortunato, Katharina Maniura-Weber, Jorg F. Loffler, Markus Rottmar
Summary: The study demonstrates that an amorphous metal based on palladium shows substantial thrombogenic resistance compared to a state-of-the-art titanium alloy, reducing platelet activation and delaying fibrin formation in contact with human whole blood. However, it also promotes platelet spreading, challenging the traditional view that spreading equals activation. Mechanistic analysis reveals changes in adhered fibrinogen and modified alpha(IIb)beta(3) integrin expression as factors underlying the superior performance of Pd glass in direct blood-contact applications. Structural, thermophysical, and physicochemical characterization further supports the potential of Pd-based glass as a promising bulk material for blood-contacting devices without the need for additional coatings.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Polymer Science
Sara Perez Davila, Laura Gonzalez Rodriguez, Stefano Chiussi, Julia Serra, Pio Gonzalez
Summary: This paper reviews the effects of sterilization techniques on the properties of PLA medical devices, focusing on how conventional sterilization methods impact their physicochemical and biocompatible properties. It also presents emerging and alternative sterilization methods for sensitive biomaterials.
Review
Engineering, Mechanical
Liwen Zhang, Guang Liu, Yurun Guo, Yan Wang, Deyuan Zhang, Huawei Chen
Summary: This article summarizes the latest progress in natural functional surfaces for medical devices, which have a significant impact on device performance and patient health. The coupling effects and featured micro-nano structures enable these surfaces to achieve ultra-slipperiness and strong wet attachment.
CHINESE JOURNAL OF MECHANICAL ENGINEERING
(2022)
Article
Chemistry, Physical
Urban Ajdnik, Thomas Luxbacher, Alenka Vesel, Alja Stern, Bojana Zegura, Janja Trcek, Lidija Fras Zemljic
Summary: A study focused on the formation of a polysaccharide-based bilayer coating on PDMS films for enhanced protein repulsion and antimicrobial activity. The results from various experiments showed the improved antifouling properties of the bilayer coatings compared to a reference or single layer, indicating potential for medical device applications.
Article
Computer Science, Information Systems
Denis Bernard, Constantino Msigwa, Jaeseok Yun
Summary: This article introduces a computing device called Medical Edge, which converts conventional medical equipment into IoT-enabled devices for intelligent data collection. By using a neural network model, the device accurately predicts blood pressure. The experimental results are in compliance with international standards and show promising prospects.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Huifeng Wang, Samantha Huddleston, Jian Yang, Guillermo A. Ameer
Summary: Regenerative medicine aims to restore tissue and organ function, but faces barriers such as the lack of proregenerative biomaterials, a complex regulatory process, and user adoption challenges. Biodegradable polymers, although important in regenerative medicine, have limitations in their mechanical and degradation properties. Despite these limitations, a small number of biodegradable polymers have dominated the market for the past 50 years.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Jessica R. Vlcek, Mohammadhasan Hedayati, Alyssa C. Melvin, Melissa M. Reynolds, Matt J. Kipper
Summary: The study proposes to mitigate unfavorable biological reactions with blood-contacting medical devices by designing multifunctional surfaces that release nitric oxide and mimic features of the vascular endothelial glycocalyx. These surfaces interact with coagulation components, inflammatory cells, and bacterial cells, improving platelet-, leukocyte-, and bacteria-surface interactions. New blood-compatible materials should be designed with multiple features to better address the multiple modes of failure of blood-contacting medical devices.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Corrine Ying Xuan Chua, Hsuan-Chen Liu, Nicola Di Trani, Antonia Susnjar, Jeremy Ho, Giovanni Scorrano, Jessica Rhudy, Antons Sizovs, Graziano Lolli, Nathanael Hernandez, Maria Concetta Nucci, Roberto Cicalo, Mauro Ferrari, Alessandro Grattoni
Summary: Carbon fibers reinforced polymers (CFRPs) are increasingly being used in the medical field due to their potential to replace traditional metal medical implants. After comprehensive evaluation of material properties and biocompatibility, most CFRPs demonstrate biocompatibility in vitro and in small animal models. Future work will focus on further material assessment and chronic toxicity studies in larger animal models for orthopedic applications.
Article
Chemistry, Multidisciplinary
Maria N. Koryazhkina, Dmitry O. Filatov, Stanislav V. Tikhov, Alexey I. Belov, Dmitry A. Serov, Ruslan N. Kryukov, Sergey Yu. Zubkov, Vladislav A. Vorontsov, Dmitry A. Pavlov, Evgeny G. Gryaznov, Elena S. Orlova, Sergey A. Shchanikov, Alexey N. Mikhaylov, Sungjun Kim
Summary: The electrical characteristics and resistive switching properties of memristive devices using silicon oxide and titanium nitride as the insulator and electrode materials have been studied. The as-fabricated devices do not require electroforming, but their resistance state cannot be stored before thermal treatment. After the thermal treatment, the devices exhibit bipolar-type resistive switching with synaptic behavior, where filaments form in the insulator due to the effect of traps. These devices can be easily integrated with traditional analog-digital circuits to implement new-generation hardware neuromorphic systems.
Review
Chemistry, Multidisciplinary
Karen K. Gleason
Summary: Initiated chemical vapor deposition (iCVD) is a dry method for designing organic and hybrid polymers, which provides conformal surface modification over intricate geometries. iCVD films can be grown with uniformity, high-purity, and pinhole-free properties, and can be applied onto flexible substrates, 2D materials, and liquids. The functional groups in iCVD polymers offer fine-tuning of surface energy, surface charge, and responsive behavior. iCVD polymers have various morphologies, such as nanostructured surfaces, nanoporosity, and shaped particles, and they are widely used in sensing, electronics, optics, electrochemical energy storage, and biotechnology applications.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Fang-Yu Chou, Shintaro Hara, Kazuto Uchida, Youichi Matsuo, Tsukuru Masuda, Ryo Yokoi, Toshiya Ono, Masaki Anraku, Takashi Isoyama, Madoka Takai
Summary: Surface modification of silicone elastomers (SEs) with hemocompatible copolymers is crucial for long-term use of medical devices. This study demonstrates an effective method using alkaline solution to produce silanol groups on SEs for modifying phosphorylcholine-based copolymer. The resulting copolymer film on SEs is stable and inhibits blood coagulation.
FRONTIERS IN MATERIALS
(2022)
Review
Chemistry, Physical
Angela R. Dixon, Isabelle Vondra
Summary: Mosquitoes have unique characteristics and behaviors that have led to the development of various beneficial technologies for medical applications, such as mosquito-inspired microneedles, anticoagulants from their saliva, and technologies inspired by mosquito vision and olfaction.
Article
Polymer Science
Liwei Ye, Barry C. Thompson
Summary: Direct Arylation Polymerization (DArP) is an eco-friendly, convenient, and cost-effective method for conjugated polymer synthesis, but the commonly used solvents are hazardous. By utilizing a sustainable alternative solvent, p-cymene, the synthesis efficiency and product quality can be significantly improved.
Article
Nanoscience & Nanotechnology
Anika B. Asha, Yi-Yang Peng, Qiuli Cheng, Kazuhiko Ishihara, Yang Liu, Ravin Narain
Summary: The rapid accumulation of dead bacteria or protein on a bactericidal surface can reduce its effectiveness and alter its biocidal activity. Therefore, developing a self-cleaning surface is crucial. In this project, a sugar-responsive self-cleaning coating has been developed, which can kill attached microbials and release dead cells and foulants.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Shin-ichi Yusa, Daishiro Oka, Yasuhiko Iwasaki, Kazuhiko Ishihara
Summary: Well-defined pH-responsive biocompatible random copolymers were synthesized and their pH-responsive association and dissociation behavior were studied using various techniques. The copolymers exhibited different microstructures and solubility properties under acidic and basic conditions.
Article
Polymer Science
Thi Lien Nguyen, Kazuhiko Ishihara, Shin-ichi Yusa
Summary: The self-assembly of pH-responsive random and block copolymers composed of 2-(N,N-diisopropylamino)ethyl methacrylate and 2-methacryloyloxyethyl phosphorylcholine was studied in aqueous media. The copolymers existed as single polymer chains in an acidic environment, but formed separated micelles in a basic environment.
Article
Materials Science, Biomaterials
Kazuhiko Ishihara, Miu Kaneyasu, Kyoko Fukazawa, Ren Zhang, Yuji Teramura
Summary: This study analyzed the effects of differentiated cells on stem cell differentiation by co-culturing in a cell-encapsulated double-layered hydrogel system. The hydrogel's creep modulus controlled cell proliferation and differentiation, especially when exposed to bone morphogenetic protein-2, leading to the differentiation of C3H10T1/2 cells into mature osteoblasts. The close contacting double-layered hydrogel structure facilitated communication between different cell types, enhancing alkaline phosphatase activity in the cells.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Kohei Kitano, Kazuhiko Ishihara, Shin-ichi Yusa
Summary: The triblock copolymer PEG-b-PUEM-b-PMPC was synthesized via controlled radical polymerization, with a UCST exhibited by the PUEM block and the ability of PMPC to dissolve hydrophobic fullerenes to form a complex. The EUM can serve as a carrier for releasing encapsulated drugs, while the PUEM shell can encapsulate an anticancer drug which can be released by heating. The water-soluble C-70/EUM complex can also generate singlet oxygen upon visible-light irradiation, making it a potential photosensitizer for photodynamic therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Anna Adler, Yuuki Inoue, Kristina N. Ekdahl, Teruhiko Baba, Kazuhiko Ishihara, Bo Nilsson, Yuji Teramura
Summary: Alternative liposome surface coatings with poly(2-methacryloyloxyethyl phosphorylcholine) (MPC)-based lipids (PMPC-lipids) can effectively suppress protein adsorption and C3 binding, especially with higher molecular weight and molar ratio of PMPC-lipids. Apolipoprotein A-I is detected on PMPC-liposomes with higher molecular weight, while alpha(2)-macroglobulin is detected on non-modified, PEGylated, and PMPC-liposomes with shorter polymer chains. There is a correlation among the PMPC molecular weight, molar ratio, and C3 binding.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Kyoko Fukazawa, Mingwei Mu, Sheng-Han Chen, Kazuhiko Ishihara
Summary: Poly(ether ether ketone) (PEEK) has been widely used as a replacement for metal implants in biomedical fields. In this study, zwitterionic copolymers were used to modify the surface of PEEK via photoinduced reactions. The findings suggest that the molecular structure of the copolymers affects the surface properties.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
Hiroaki Hatano, Fanlu Meng, Momoko Sakata, Akira Matsumoto, Kazuhiko Ishihara, Yuji Miyahara, Tatsuro Goda
Summary: This study demonstrates the energy independent permeation of a water-soluble phospholipid-mimicking random copolymer through epithelial barriers, as well as the successful transepithelial delivery of insulin while maintaining its bioactivity. These findings are significant for the development of efficient and safe transepithelial drug delivery systems.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Sayaka Fujii, Shohei Kozuka, Kaito Yokota, Kazuhiko Ishihara, Shin-ichi Yusa
Summary: In this study, vinyl group-decorated silica particles were covered with cross-linked PMPC to prepare hollow particles. The thickness of the hollow particle shell can be controlled by the polymerization solvent quality. These biocompatible PMPC hollow particles can be used as drug carriers.
Article
Chemistry, Multidisciplinary
Kohei Kitano, Kazuhiko Ishihara, Shin-ichi Yusa
Summary: In this study, double-hydrophilic diblock copolymers were synthesized and used to form water-soluble complexes with fullerene, which have potential applications as photosensitizers for photodynamic therapy.
Review
Materials Science, Multidisciplinary
Kazuhiko Ishihara
Summary: This review summarizes recent research on the design of polymer material systems based on biomimetic concepts and reports on medical devices implementing these systems. Incorporating biomolecules into artificial systems can significantly advance material science. Zwitterionic polymers have unique properties that make them potential surface modification materials for enhancing the performance and safety of conventional medical devices. New surface technologies using zwitterionic polymers have been developed for human-friendly medical devices in various fields.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2022)
Article
Materials Science, Biomaterials
Anika Benozir Asha, Artjima Ounkaew, Yi-Yang Peng, Mohammad Reza Gholipour, Kazuhiko Ishihara, Yang Liu, Ravin Narain
Summary: Infections caused by biofouling are a major concern in the healthcare sector. To combat these infections, multifunctional coatings with antifouling and antibacterial properties are widely used. However, scratches and damages to the coating can compromise its functionality. In this study, a biocompatible and multifunctional coating with self-healing, antifouling, and antibacterial properties was developed. The coating demonstrated excellent performance against protein and bacteria and its durability was significantly extended.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Shukanta Bhowmik, Thu Thao Pham, Rintaro Takahashi, Dongwook Kim, Hideki Matsuoka, Kazuhiko Ishihara, Shin-ichi Yusa
Summary: Cationic random copolymers and anionic random copolymers were prepared using a reversible addition-fragmentation chain transfer method. The copolymers were mixed to form water-soluble polyion complex micelles, with MPC-rich surface and MCC/MPS core. The size of these micelles depended on the mixing ratio of the oppositely charged copolymers.
Review
Nanoscience & Nanotechnology
Kazuhiko Ishihara, Xinfeng Shi, Kyoko Fukazawa, Tetsuji Yamaoka, George Yao, James Yuliang Wu
Summary: Contact lenses are a successful application of biomaterials, and the chemical structure of the polymers used in contact lenses is crucial. Different types of contact lenses have been developed based on the chemical structure of polymers, considering factors like mechanical properties, optical properties, and compatibility. Advances in contact lens materials have addressed issues like oxygen permeability and biocompatibility, improving comfort and duration of use. Surface polymer modification has allowed for better long-term use and reuse of contact lenses.
ACS APPLIED BIO MATERIALS
(2023)
Review
Materials Science, Biomaterials
Kazuhiko Ishihara, Kyoko Fukazawa
Summary: Fabrication of devices for accurate recognition, detection, and separation of target molecules is crucial in biotechnology. Biomolecules are complexed with a substrate to recognize and capture specific molecules from mixtures. This article summarizes the use of polymeric materials to construct biointerfaces that mimic the structure and properties of cell membranes. The requirements for biointerfaces to prevent non-specific interactions and the issue of protein adsorption are discussed, along with methodologies for stable formation of these interfaces on material surfaces.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)